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Pitavastatin 147511-69-1

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CAS No.:

147511-69-1

Port:

Shanghai

Packaging:

25kg/bag

Price valid (until):

2024-06-18

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SHANDONG LOOK CHEMICAL CO.,LTD

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Product Name:	Pitavastatin
Synonyms:	ITAVASTATIN;monocalciumbis{(3r,5s,6e)-7-[2-cyclopyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate};PitavastatinCa;PITVASTATIN;(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid;PITAVASTATIN;( )-(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoic acid;6-Heptenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, (3R,5S,6E)-
CAS:	147511-69-1
MF:	C25H24FNO4
MW:	421.46
EINECS:
Product Categories:	LIVALO;API
Mol File:	147511-69-1.mol

Pitavastatin Chemical Properties

Melting point	182 - 185°C
Boiling point	692.0±55.0 °C(Predicted)
density	1.352±0.06 g/cm3(Predicted)
storage temp.	-20°C, Hygroscopic
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	4.24±0.10(Predicted)
form	Solid
color	White to Off-White
Stability:	Hygroscopic
CAS DataBase Reference	147511-69-1(CAS DataBase Reference)
EPA Substance Registry System	6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)- (147511-69-1)

Safety Information

Hazardous Substances Data

147511-69-1(Hazardous Substances Data)

MSDS Information

Pitavastatin Usage And Synthesis

Description	Pitavastatin (Brand Name: LIVALO) is an inhibitor of HMG-CoA reductase which catalyzes the first step of cholesterol synthesis. It appears as odorless and white to pale-yellow powder. It takes effects by reducing the level of certain fatty substances such as cholesterol in the body. Therefore, it is mainly indicated for the treatment of hypercholesterolaemia and for the prevention of cardiovascular diseases. It can not only lower the high cholesterol and triglyceride in certain patients, but also can increase the content of high density lipoprotein (HDL), the “good” cholesterol levels. It should be generally administrated together with a proper diet.
Reference	https://en.wikipedia.org/wiki/Pitavastatin http://www.rxlist.com/livalo-drug.htm https://www.drugs.com/cdi/pitavastatin.html
Uses	HMGA reductase inhibitor
Definition	ChEBI: A hydroxy monocarboxylic acid anion that is the conjugate base of pitavastatin, obtained by deprotonation of the carboxy group.
Brand name	[Name previously used: Itavastatin].
Biological Activity	pitavastatin (nk-104) is a potent hmg-coa reductase inhibitor, pitavastatin inhibited cholesterol synthesis from acetic acid with an ic50 of 5.8 nm in a human liver cancer cell line (hepg2).
Enzyme inhibitor	This HMG-CoA reductase inhibitor (FW = 421.46 g/mol; CAS 147511-69- 1; IUPAC Name: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin- 3-yl]-3,5-dihydroxyhept-6-enoic acid), also known as itavastatin, itabavastin, nisvastatin, NK-104, NKS-104, and the trade name Livalo?, is indicated for ameliorating hypercholesterolemia and preventing cardiovascular disease. NK-104 potency is dose-dependent and is roughly equivalent to that of atorvastatin. It is well-tolerated in the treatment of patients with hypercholesterolemia. Pitavastatin uptake is carrier-mediated. Target(s): Reduces inflammatory cytokine production from human bronchial epithelial cells; Decreases microtubule tau protein levels via the inactivation of Rho/ROCK; Inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model; Suppresses therosclerosis induced by chronic inhibition of the synthesis of nitric oxide in moderately hypercholesterolemic rabbits; Decreases the expression of endothelial lipase both in vitro and in vivo; Inhibits NFkB pathway in brain; Inactivates NFkB and decreases IL-6 production through Rho kinase pathway in MCF-7 human breast cancer cells; Reduces C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells; Inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation; Inhibits upregulation of intermediate conductance calcium-activated potassium channels and coronary arteriolar remodeling induced by long-term blockade of nitric oxide synthesis; Inhibits migration and proliferation of rat vascular smooth muscle cells.

Basic Info

Product Name:

Pitavastatin

Other Name:

6-Heptenoic acid,7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-,(3R,5S,6E)-;6-Heptenoic acid,7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-,[S-[R*,S*-(E)]]-;(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid;Pitavastatin;NK 104;(+)-(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoic acid;(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid;1187885-60-4

CAS No.:

147511-69-1

Molecular Formula:

C25H24FNO4

InChIKeys:

InChIKey=VGYFMXBACGZSIL-MCBHFWOFSA-N

Molecular Weight:

421.46

Exact Mass:

421.46

UNII:

M5681Q5F9P

DSSTox ID:

DTXSID4046448|DTXSID1048384|DTXSID50694059

NCI Thesaurus Code:

C87751

ATC Code:

C - Cardiovascular system

HScode:

3004909090

Categories:

Circulatory System Drugs

Characteristics

PSA:

90.65000

XLogP3:

3.45

Density:

1.352±0.06 g/cm3(Predicted)

Boiling Point:

692.0±55.0 °C(Predicted)

Flash Point:

372.3±31.5 °C

Refractive Index:

1.680

Water Solubility:

Very slightly soluble

Storage Conditions:

Store at room temperature between 15 °C and 30 °C (59 deg to 86 °F). Protect from light.

Vapor Pressure:

2.32X10-17 mm Hg at 25 °C (est)

Henrys Law Constant:

Henry's Law constant = 0.89X10-19 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa = 4.3 (carboxy) (est)

Experimental Properties:

MW: 493.45. MP: 138-139 °C. Specific optical rotation: +8.84 deg at 32 °C/D (c = 0.92 in chloroform). Soluble in acetonitrile /Pitavastatin lactone/|Hydroxyl radical reaction rate constant = 1.00X10-11 cu cm/molecule-sec at 25 °C (cis); 1.08X10-11 cu cm/molecule-sec at 25 °C (trans) (est)|Ozone reaction rate constant = 6.82X10-17 cu cm/molecule-sec at 25 °C (cis); 1.36X10-16 cu cm/molecule-sec at 25 °C (trans) (est)

See More Pitavastatin Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

Reproductive toxicity, Additional category for effects on or via lactation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child H362 May cause harm to breast-fed children
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P263 Avoid contact during pregnancy and while nursing. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Pitavastatin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate

Location:
hisense intelligence valley,no 2116,of phoenix road

Payment Terms:
TT against copy of documents,D/P,L/C

Average lead Time:
7

Total Annual Revenue:
Less than $1 million

Total Employees:
11-50

Year of Establishment:
2017

SHANDONG LOOK CHEMICAL CO.LTD, a new chemical enterprise in researching, manufacturing and supplying of chemicals located in beautiful “Spring City”-Jinan.Our company mainly working on the researching new-born APIs, intermediate ( especially Carbohydrate derivatives series). Meanwhile, we made huge breakthrough in industries of food, feed additives, cosmetics ,dye and industrial chemicals. Our company enjoyed great reputation both domestic and abroad under the belief of “Integrity management,Quality controlling and Customer orientation”. Web : www.chinalookchemical.com

We had been cooperated with NingXia University and Shandong University on more than ten projects for years and which had been in mass production on the market. We now have more than 80 people in our team and built research center in Jinan and Ningxia. Our manufacturing site allocated in chemical industry parks of Zhangqiu, Heze, Dezhou and Ningxia Fine Chemical Park. We strictly complying with ISO9001 and ISO 2000 standard in manufacturing process, our lab and workshop tightly in accordance with GMP standard.Our products best selling in Europe, South and North America,Asia pacific area and Africa. We sincerely welcome new and regular customers around the world visit us for business negotiation.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Saudi Arabia	Pitavastatin	10000 MG	Jun 6, 2024
Saudi Arabia	pitavastatin	10 G	Jun 6, 2024

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