Factory Supply Higher Quality Hydrocortison Acetate Raw Materials CAS 50-03-3
1 Inquiries
50-03-3
Pharmaceutical Grade
0%
qingdao
Airuike
100g;1kg;25g
2024-08-05
api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceHydrocortisone acetate is a corticosteroid, used to decrease swelling, itching, and pain that is caused by minor skin irritations or by hemorrhoids.
Cortisol 21-acetate is a tertiary alpha-hydroxy ketone and a cortisol ester.|Hydrocortisone Acetate is the synthetic acetate ester form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes.
white powder
ChEBI: Cortisol 21-acetate is a tertiary alpha-hydroxy ketone and a cortisol ester.
The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.]Basic Info-
Product Name:
Hydrocortisone acetate
Other Name:(11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate;11-beta,17-alpha-dihydroxy-21-acetoxypregesterone;11beta17alpha-Dihydroxy-21-acetoxypregesterone;17-alpha-hydrocorticosterone21-acetate;17alpha-Hydrocorticosterone-21-acetate;Cortisone Acetate EP Impurity A（Hydrocortisone Acetate）;Hydrocortisone Impurity 3（Hydrocortisone EP Impurity C）
CAS No.:50-03-3
Molecular Formula:C23H32O6
InChIKeys:ALEXXDVDDISNDU-JZYPGELDSA-N
Molecular Weight:404.5
Exact Mass:404.50
BRN:2066841
EC Number:200-004-4
UNII:3X7931PO74
NSC Number:741
DSSTox ID:DTXSID0048686
NCI Thesaurus Code:C61785
Color/Form:White to Off-White
HScode:29372100
Categories:
Characteristics-
PSA:
100.90000
XLogP3:2.35240
Density:d420 1.289
Melting Point:223 °C (dec.)(lit.)
Boiling Point:446.1°C (rough estimate)
Flash Point:196.2ºC
Refractive Index:1.4593 (estimate)
Water Solubility:Insoluble in water.
Storage Conditions:0-6ºC
Toxicity:LD50 intraperitoneal in mouse: 2300mg/kg
PKA:12.42±0.70(Predicted)
Collision Cross Section:198.8 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|207.2 Ų [M+K]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|203 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|196.3 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|196.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|196.5 Ų [M-H]-
Critical Temperature & Pressure:0-6°C
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals
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Location:
Huangdao District, Qingdao City, Shandong Province (formerly Room 606-2, Building 1, No. 10 Beijing Road, Jiaonan City)
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Payment Terms:
TT against copy of documents,D/P,D/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
15
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
51-100
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Year of Establishment:
2023
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Certifications:
Credit rating certificate,Hazardous Chemicals Business License
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
hydrocortisone acetate
95 G Oct 14, 2024 Post an enquiry for this product
