Factory Direct Supply High Quality TNJONE 99% Purity Metamizole sodium 68-89-3

Metamizole or dipyrone, is a painkiller, spasm reliever and fever reliever. Like ibuprofen, it has anti-inflammatory effects. It is most commonly given by mouth or by injection. Although it is available over-the-counter in some countries, it is prescription or banned in other countries, due to its potential for adverse events, including agranulocytosis. It is in the ampyrone sulfonate family of medicines.
Dipyrone is a water soluble pyrazolone derivative available in oral, rectal and injectable forms. It has analgesic, antipyretic, antispasmodic, and anti-inflammatory properties. Dipyrone is used most commonly to treat severe pain, particularly, for pain associated with smooth muscle spasm or colic affecting the gastrointestinal, biliary or urinary tracts. It is useful for fever that is refractory to other treatment. Because of the risk of serious adverse effects, such as agranulocytosis, its use is justified only in serious situations where no alternative is available or suitable.

Name	Metamizole sodium
CAS NO.	68-89-3
purity	99%
Standard packing material	Bag/Box
Appearance	White Powder
Shelf Life	2Years
storage condition and solubility	Inert atmosphere,Store in freezer, under -20°C; soluble in water.

Item	Standard	Result
Appearance	White or almost white crystalline powder	Almost white crystalline powder
Melting point	152-156°C	154.6-155.1°C
Specific optical rotation	-16° to -19°	-17.5°
Identification	(1)The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the assay.	Complies
	(2)UV absorption Max. at 266nm.	Complies
	(3)IR spectra is consistent with CRS.	Complies
PH	4.5-6.5	5.7
Chloride	0.02% max	<0.02%
Fluorides	4.8%min	4.9%
Related substances	Individual impurity not more than 0.5%	0.35%
	Total impurities not more than 2.0%	0.76%
Water	0.5% max	0.13%
Residue on ignition	0.1%max	0.06%
Heavy metals	Less than or egual to 20 millionths	Less than20 millionths
Assay(C12H14Cl2FNO4S)	98.0%min	99.0%

Function&Application:

• It has the effect of detoxification, analgesic and anti-rheumatic etc and mainly used for cooling, but also can be applied to cure the acute arthritis, rheumatic pain, muscle pain and headache etc.
  A non-steroidal anti-inflammatory drug that, when coadministered with mophine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.
  Methamizole sodium has expressed analgesic and fever-reducing properties and poorly expressed anti-inflammatory action, and is very convenient in cases where high concentrations of drug need to be quickly reached. Methamizole sodium is used for relieving pain of various origins (renal and biliary colic, neuralgia, myalgia, trauma, burns, headaches, and toothaches). Use of this drug may cause allergic reactions, and long-term use may cause granulocytopenia.

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