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Dipyrone

Dipyrone structure

CAS No:
68-89-3
Formula:
C13H17N3O4S.Na
Chemical Name:
Dipyrone
Synonyms:
Methanesulfonic acid,1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-,sodium salt (1:1);Methanesulfonic acid,(antipyrinylmethylamino)-,sodium salt;Methanesulfonic acid,[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-,sodium salt;Dipyrone;Analgin;Metamizol;Methylmelubrin;Noramidopyrine methanesulfonate sodium salt;Novalgin;Novaminsulfone sodium;Pyralgine;Pyretin (pharmaceutical);Sulpyrine;Sulpyrin;Novamidazophen;Sodium 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate;Sodium noramidopyrine methanesulfonate;Novaminsulfonum;Novaminophenazone;Sodium (antipyrinylmethylamino)methanesulfonate;Metilon;Noramidopyrine methanesulfonate sodium;Sodium novaminsulfonate;Novaminsulfonium;Neo-melubrine;Noveltex;Pharmalgine;Sulpin;ARPF;Optalgin;Diprofarn;Noraminophenazone methanesulfonate sodium salt;Methampyrone;Novalgetol;Novaminsulfone;Metamizole;Narone;Gifaril;Metapyrin;Metamizole sodium;Pyretin;Methamizole sodium;Algopyrin;Algocalmin;Conmel;Noraminophenazone sodium mesylate;Analgine;Andolor;Lisador;Anador;Sodium metamizole;Metamizole sodium salt;Restriva;57904-20-8
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

solid

Metamizole sodium is an organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an antipyretic, a prodrug and a cyclooxygenase 3 inhibitor. It contains a metamizole(1-).|A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.

Dipyrone Basic Attributes

Molecular Weight：

333.34

Exact Mass：

333.075928

EC Number：

200-694-7

UNII：

VSU62Z74ON

DSSTox ID：

DTXSID8020543

ATC Code：

N02BB02|N - Nervous system

HScode：

2933192000

Characteristics

PSA：

95.75000

XLogP3：

1.50410

Appearance：

White or almost white crystal powder

Density：

1.388 g/cm³

Melting Point：

187ºC

Storage Conditions：

2-8°C

Toxicity：

Oral-rat LD50: 3000 mg/kg;Oral-Mouse LD50: 2891 mg/kg

Flammability characteristics：

Combustible; burning produces toxic nitrogen oxides, sulfur oxides and sodium oxide fumes

Safety Information

wgk germany：

hazard class code：

42/43

safety instructions：

RTECS Number：

PB1300000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P201, P202, P273, P281, P308+P313, P405, P501

Hazard Statements：

H361

GHS Classification：

|Warning|H361 (83.62%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P273, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 117 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H302 (17.46%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P272, P280, P281, P285, P301+P312, P302+P352, P304+P341, P308+P313, P321, P330, P333+P313, P342+P311, P363, P405, and P501|Aggregated GHS information provided by 67 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Drugs that are used to reduce body temperature in fever. (See all compounds classified as Antipyretics.)

MeSH Entry Terms：

Algopyrin

Dipyrone Use and Manufacturing

Uses

Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:333.34
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:333.07592146
Monoisotopic Mass:333.07592146
Topological Polar Surface Area:92.4
Heavy Atom Count:22
Complexity:552
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Sodium bisulfite

Price Analysis

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