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China Supplier Factory Direct Supply high quality USP/EP 99% High Quality Tacrolimus Raw Powder CAS 104987-11-3 buy - large image1

China Supplier Factory Direct Supply high quality USP/EP 99% High Quality Tacrolimus Raw Powder CAS 104987-11-3 buy - image1

China Supplier Factory Direct Supply high quality USP/EP 99% High Quality Tacrolimus Raw Powder CAS 104987-11-3 buy - image2

China Supplier Factory Direct Supply high quality USP/EP 99% High Quality Tacrolimus Raw Powder CAS 104987-11-3 buy - image3

China Supplier Factory Direct Supply high quality USP/EP 99% High Quality Tacrolimus Raw Powder CAS 104987-11-3 buy - image4

China Supplier Factory Direct Supply high quality USP/EP 99% High Quality Tacrolimus Raw Powder CAS 104987-11-3

2 Inquiries

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CAS No.:

104987-11-3

Grade:

Function
1. Tacrolimus is used with other medications to prevent rejection of a kidney, heart, or liver transplant.
2. Tacrolimus is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.
3. Tacrolimus can be combined with steroids, azathioprine (Imuran Azasan) or mycophenolate mofetil (CellCept).

4. Tacrolimus is a macrolide antibiotics. Immunosuppressants. Same mechanism of action as cyclosporine, mainly inhibits the synthesis of interleukin-2. Used for rejection of organ transplants

5. A macrolide that binds to FK506 binding protein (FKBP) to form a complex that reduces peptidyl prolyl isomerase activity in T cells.

6. FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system

7. Tacrolimus for use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart,

Company Profile

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Shaanxi TNJONE Pharmaceutical Co., Ltd is a high-tech enterprise mainly engaged inthe development and sale of pharmaceutical chemical raw materials and relatedproducts.The company has advanced and perfect supporting system,forming advancedchemical synthesis technology, which can quickly meet the individual needs and serialdevelopment from suitable detection to industrial production.Qur business covers morethan 30 countries, most of customers from Europe, Southeast Asia and other countriesin the world, we can guarantee the quality and price. Our enterprise purpose is basedon the market, strengthen strength, take the road of scientific environmental protectionand sustainable development, rely on the country. The company has a strong financialstrength and a good business environment, can provide customers with quality,efficientand fast service.

Our Advantages

1.High quality and competitive price.
2.Free sample for your evaluation.
3.Promptly delivery by well-reputed shipping lines.
4.Trial order is available for testing after samples.
5.We will inform you all the information at every stage in advance.
6.Packaging can gear to buyers' special request.

Our factory

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How to order

Before ordering	Please send what items and what quantity you need
Send quotation	We will send you a quotation in detail with total
Payment ways chosen	Please choose one of the payment way you preferred. Our payment ways: City bank,BTC,Bank wire, Wise,Master Card , Tether
After payment	Please offer shipping address after payment for shipment.
Tracking	We will provide the tracking after goods sent.
Lead time	About 1-5 working days after payment
Shipping time	About 8-15 days door to door
After-sale service	Available always

Basic Info

Product Name:

Tacrolimus

Other Name:

15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-;(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone;FR 900506;FK 506;Tsukubaenolide;L 679934;Fujimycin;(-)-FK 506;Tacrolimus;Prograf;Protopic;Advagraf;TacroBell;FK506;Prograph;Envarsus XR;Astagraf XL;Hecoria;Tacropic;Protopy;Modigraf;Envarsus

CAS No.:

104987-11-3

Molecular Formula:

C44H69NO12

InChIKeys:

InChIKey=QJJXYPPXXYFBGM-LFZNUXCKSA-N

Molecular Weight:

804.02

Exact Mass:

804.02

EC Number:

1308068-626-2

DSSTox ID:

DTXSID5046354

Categories:

Other Chemical Drugs

Characteristics

PSA:

178 Å²

XLogP3:

3.3

Appearance:

white solid

Density:

1.2±0.1 g/cm3

Melting Point:

113-115°C

Flash Point:

2℃

Refractive Index:

1.549

Water Solubility:

Freely soluble in DMSO or ethanol. Poorly soluble in water.soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.DMSO: >3 mg/mL

Storage Conditions:

−20°C

Vapor Pressure:

8.37X10-32 mm Hg at 25 °C (est)

Henrys Law Constant:

Henry's Law constant = 4.74X10-24 atm-cum/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 2.94; pKa2 = 9.95; pKa3 = 14.07 (est)

Experimental Properties:

Hydroxyl radical reaction rate constant = 3.81X10-10 cu cm/molec-sec at 25 °C (est)|Ozone radical reaction rate constant = 8.719X10-16 cu cm/molec-sec at 25 °C (est)

See More Tacrolimus Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Reproductive toxicity, Category 2

Specific target organ toxicity â repeated exposure, Category 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H361 Suspected of damaging fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Tacrolimus Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Semaglutide,Tirzepatide,API,Vitamins,Food Additive

Location:
No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New City, Xi 'an, Shaanxi Province

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
5

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2019

Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital Xi 'an, is committed to the peptide industry, pharmaceutical raw materials, food and feed additives, veterinary drugs and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products, "world peace and health" as its responsibility, the company adhering to the "meet all customer requirements for products" as the service concept, Guarantee "provide qualified products" as the service principle, so that you get "God-like" noble shopping enjoyment. Our company has more than 1000 kinds of polypeptides, raw materials inventory, at any time to meet the various needs of customers for products. Is your best partner.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Uzbekistan	China GMP Factory Direct Supply 99% Purity Tacrolimus FK-506 powder CAS 104987-11-3 Sinoway	1 KG	Oct 12, 2023
Saudi Arabia	Tacrolimus	10 G	Sep 14, 2024

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Name	Tacrolimus
CAS NO.	104987-11-3
purity	99%
Standard packing material	Bag/Box
Appearance	white power
Shelf Life	2Years
storage condition and solubility	Inert atmosphere,at 2-8°C;Sealed in dry,Store in freezer