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Home > Active Pharmaceutical Ingredients > Other Chemical Drugs > Glimepiride for Sale > Hot Sell High Quality Glimepiride Powder CAS 93479-97-1 for Treatment of Diabetes
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Hot Sell High Quality Glimepiride Powder CAS 93479-97-1 for Treatment of Diabetes

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Unit Price: Get Latest Price
CAS No.:

93479-97-1

Grade:

Pharmaceutical Grade

Content:

98%

Port:

china any port

Brand:

TNJONE

Packaging:

1kg ,25kg or according to customer's detail requirement.

Price valid (until):

2025-12-30

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Semaglutide,Tirzepatide,API,Vitamins,Food Additive

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    Hot Sell High Quality Glimepiride Powder CAS 93479-97-1 for Treatment of Diabetes

    What  is Glimepiride ?


    Glimepiride is a medium- to long-acting sulfonylureaantidiabetic drug. Like all sulfonylureas, glimepiride acts as an insulin secretagogue. It lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors.

    Glimepiride is a third-generation sulfonylurea long-acting antidiabetic drug whose main mechanism of hypoglycemic effect is to stimulate insul in secretion from pancreatic β-cells and partially improve the sensitivity of surrounding tissues to insul in. It binds to and dissociates from insul in receptors faster than glibenclami de and is less likely to cause severe hypoglycemia. The mechanism of action is through binding to the sulfonylurea receptor (a protein with a relative molecular mass of 6.5×104) on the surface of pancreatic β-cells, which is coupled to ATP-sensitive K+ (KATP) channels, prompting the closure of KATP channels, causing depolarization of cell membranes, opening voltage-dependent calcium channels, inducing insul in release by Ga2+ inward flow, and inhibiting hepatic glucose synthesis. Recent studies have shown that different sulfonylurea coal drugs have different affinities for KATP. The order is: euglycemia = glimepiride > toluenosulfonylurea > chlorosulfonylurea. In addition, glimepiride can also increase cardiac glucose uptake through a non-insul in-dependent pathway, which may be due to the increased action of two proteins, glucose transport factor 1,4, expression. Since the effect of glimepiride on cardiovascular KATP channels is weaker than that of glibenclami de, gliclazide and glipizide. Therefore, cardiovascular adverse effects are also rare.
    Items Specifications
    Product Name Glimepiride
    CAS No. 93479-97-1
    Appearance white powder
    Assay 98%
    MF C24H34N4O5S
    MW 490.62
    Melting Point 212.2-214.5 °C
    Density 1.29±0.1 g/cm3(Predicted)


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    Certification 

    Technical Date Sheet:


    Items
    Specification
    Results
    Assay
    ≥98%
    98.25%
    Appearance
    White or almost white crystalline powder
    Complies
    Ash
    ≤1.0%
    0.15%
    Loss on drying
    ≤5.0%
    1.06%
    Heavy metals
    ≤10ppm
    Complies
    Pb
    ≤2.0ppm
    Complies
    As
    ≤2.0ppm
    Complies
    Odor
    Characteristic
    Complies
    Particle size
    100%through 80 mesh
    Complies
    Microbioiogical:
    Total of bacteria
    ≤1000cfu/g
    100cfu/g
    Fungi
    ≤100cfu/g
    <10cfu/g
    Salmgosella
    Negative
    Complies
    Coli
    Negative
    Complies


    Function


    Glimepiride is a third-generation sulfonylurea long-acting antidiabetic drug. Its mechanism of action is to bind to the sulfonylurea receptor on the surface of pancreatic β-cells, which is coupled to ATP-sensitive K+ (KATP) channels. Promoting the closure of KATP channels, causing the depolarization of the cell membrane, the opening of voltage-dependent calcium channels, the influx of Ca2+, the release of insuline, and the inhibition of hepatic glucose synthesis. In addition, glimepiride can also increase cardiac glucose uptake through an insuline-independent pathway, which may be caused by the increased expression of two proteins, glucose transporter 1 and 4. Because glimepiride has a weak effect on cardiovascular KATP channels, adverse cardiovascular reactions are also rare.


    Application


    1. It is suitable for type 2 diabetes mellitus whose blood sugar cannot be adequately controlled by diet, exercise therapy and weight loss.
    2. Glimepiride dispersible tablets are not suitable for the treatment of type 1 diabetes (eg, the treatment of diabetic patients with a history of ketoacidosis), diabetic ketoacidosis, or the treatment of pre-diabetic coma or coma.


     Company Information 


    Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital of Xi 'an, is committed to pharmaceutical raw materials, kill varieties, food and feed additives, chemical reagents, plant extracts and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products. Our company after careful planning, hard study, gradually formed a complete service system, based on the domestic and foreign raw materials market special development. Make the raw materials industry bigger and stronger, and serve the vast number of new and old customers. With "world peace and health" as its responsibility, the company adheres to the service concept of "meeting all requirements of customers for products", and guarantees the service principle of "providing qualified products", so that you can get the "God-like" noble shopping enjoyment. Our company has more than 500 kinds of raw materials inventory at any time to meet the various needs of customers for products. The company's products all comply with the relevant national regulations, from the smallest packaging to tons of goods are available. Is your choice of raw materials the best partner.


    Shaanxi TNJONE Pharmaceutical Technology Co., Ltd. is willing to rely on the rapid development of e-commerce and national policy support of the good environment background, nesting, welcome people from all walks of life to visit our company, exchange, and seek common development, looking forward to sharing with you, win-win, to realize the dream.


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    FAQ

    1.How to get in touch with us?

    You can chat with us by Trademanager,WhatsApp or simply giving us an email, a phone call. All our contacts information can be found from our website.

     

    2.Are you a manufacturer or trade company?

    We are a professional manufacturer.

     

    3.Can I get a sample?

    Yes, free sample can be provided, but shipping cost is covered by your side.

     

    4.What's your MOQ?

    It is based on the different product. Some are 1g while some are 1 kg. Please be free to consult our salesman.

     

    5.When can I get the quotation?
    We usually quote within 1 hours after we get your inquiry. If it's a urgent order you can call us or mention it in your email subject, and we can take it as priority.

     

    6.Is there any discount?
    Yes, some products are applied for discount, but it depends on the quantity.

     

    7.Can you do OEM for me?
    Yes,we accept OEM orders, just contact us and give us your requirement. We will offer you a reasonable price and make samples ASAP.

    Certificates

    Basic Info
    Product Name:

    Glimepiride

    Other Name:

    1H-Pyrrole-1-carboxamide,3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-;1H-Pyrrole-1-carboxamide,3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-,trans-;3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide;Glimepiride;HOE 490;Amaryl;trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl] 2-oxo-1H-pyrrole-1-carboxamide;Glimperide;Glirid;Diameprid;Glimax;Limeral;Dibiglim;GlucoNovax;ZINC 537791

    CAS No.:

    93479-97-1

    Molecular Formula:

    C24H34N4O5S

    InChIKeys:

    InChIKey=WIGIZIANZCJQQY-RUCARUNLNA-N

    Molecular Weight:

    490.62

    Exact Mass:

    490.62

    HScode:

    2935009090

    Categories:

    Other Chemical Drugs

    Characteristics
    PSA:

    133

    XLogP3:

    3.9

    Appearance:

    white solid

    Density:

    1.3±0.1 g/cm3

    Melting Point:

    212.5 °C

    Flash Point:

    363.2±34.3 °C

    Refractive Index:

    1.628

    Water Solubility:

    H2O: Insoluble ;DMSO: >10 mg/mL

    Storage Conditions:

    room temp

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    Eye irritation, Category 2

    Acute toxicity - Category 3, Inhalation

    Reproductive toxicity, Category 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H319 Causes serious eye irritation

    H331 Toxic if inhaled

    H361 Suspected of damaging fertility or the unborn child

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    P203 Obtain, read and follow all safety instructions before use.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P316 Get emergency medical help immediately.

    P318 IF exposed or concerned, get medical advice.

    Storage

    P405 Store locked up.

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Semaglutide,Tirzepatide,API,Vitamins,Food Additive

    Location:

    No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New City, Xi 'an, Shaanxi Province

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    5

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    11-50

    Year of Establishment:

    2019

    Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital Xi 'an, is committed to the peptide industry, pharmaceutical raw materials, food and feed additives, veterinary drugs and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products, "world peace and health" as its responsibility, the company adhering to the "meet all customer requirements for products" as the service concept, Guarantee "provide qualified products" as the service principle, so that you get "God-like" noble shopping enjoyment. Our company has more than 1000 kinds of polypeptides, raw materials inventory, at any time to meet the various needs of customers for products. Is your best partner.
  • Inquiry History
    1 Inquiries
    Country Product Purchase Quantity Date Posted
    Egypt

    Glimepiride

    200 G Sep 18, 2023
    Post an enquiry for this product
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