Manufacturer Supply Anti-Hair Loss Powder High Quality 99% Purity Way-200070 CAS. 440122-66-7 Raw Powderanti Hair Loss Treatment API Pharmaceutical

WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.

Name	7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
CAS NO.	440122-66-7
purity	99%
Standard packing material	Bag/Box
Appearance	white Powder
Shelf Life	2Years
storage condition and solubility	Inert atmosphere,2-8°C; soluble in water

Item	Standard	Result
Appearance	White or almost white crystalline powder	Almost white crystalline powder
Melting point	152-156°C	154.6-155.1°C
Specific optical rotation	-16° to -19°	-17.5°
Identification	(1)The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the assay.	Complies
	(2)UV absorption Max. at 266nm.	Complies
	(3)IR spectra is consistent with CRS.	Complies
PH	4.5-6.5	5.7
Chloride	0.02% max	<0.02%
Fluorides	4.8%min	4.9%
Related substances	Individual impurity not more than 0.5%	0.35%
	Total impurities not more than 2.0%	0.76%
Water	0.5% max	0.13%
Residue on ignition	0.1%max	0.06%
Heavy metals	Less than or egual to 20 millionths	Less than20 millionths
Assay(C12H14Cl2FNO4S)	98.0%min	99.0%

Function&Application:

• AdministrationofWAY-200070(30mg/kgs.c.)causesnucleartranslocationofERRβreceptorsinWTmice.AdministrationofWAY-200070(30mg/kgs.c.)producesadelayed50%increaseindopamineinthestriatumofwildtypemice.WAY-200070(30mg/kgs.c.)reducesimmobilitytimeinthemousetailsuspensiontestindicatinganantidepressant-likeeffect.IngonadallyintactmaleandfemalemiceWAY-200070increasesagonisticbehaviorssuchaspushingdowChemicalbooknandaggressivegrooming,whileleavingattacksunaffected.Ovariectomized(ovx)micetreatedwithPPTfailtolearnthesociallyacquiredpreference,whileWAY-200070-treatedovxmiceshowsatwo-foldprolongedpreferenceforthefoodeatenbytheirdemonstrator.WAY-200070,showssignificantlydecreasedanxiety-likebehaviorsinboththeopen-fieldandelevatedplusmazeandsignificantlylessdepressive-likebehaviorsintheforcedswimtest.

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