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Retatrutide 99% 2381089-83-2 GLP-1, GIP, and GCGR receptors Peptide

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CAS No.:

2381089-83-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

ningbo

Brand:

Packaging:

10mg/vial, 10vials/box

Sample Available:

Yes

Price valid (until):

2024-09-22

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NBHH Technology for Pharmaceutical Inte

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,L/C,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

S3,14 bd0

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Retatrutide (LY-3437943) is an experimental drug for obesity . It is a triple hormone receptor agonist of GLP-1, GIP, and GCGR receptors. It has been shown to achieve a more than 24% mean weight reduction in non-diabetic obese or overweight adults during a phase 2 trial. The drug is a peptide with amino acid sequence YA1QGTFTSDYSIL2LDKK4AQA1AFIEYLLEGGPSSGAPPPS3.

Clinical data
Other names	LY-3437943
Identifiers

CAS Number	2381089-83-2
UNII	NOP2Y096GV
ChEMBL	ChEMBL5095485
Chemical and physical data
Formula	C ₂₂₃ H ₃₄₃ F ₃ N ₄₆ O ₇₀
Molar mass	4845.444 g·mol⁻¹

LY3437943 is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). LY3437943 inhibits for human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. LY3437943 can be used for the research of obesity

Retatrutide (LY-3437943) is an experimental drug for obesity . It is a triple hormone receptor agonist of GLP-1, GIP, and GCGR receptors. It has been shown to achieve a more than 24% mean weight reduction in non-diabetic obese or overweight adults during a phase 2 trial.

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2. Wide range of materials: pharmaceutical raw materials, intermediates, and chemicals

3. self owned factories, 198+ cooperating factories

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5. Serving 500+global clients

6. Free samples available

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NINGBO HENGHUA TECHNOLOGY DEVELOPMENT CO., LTD. Is A PROFESSIONAL ENTERPRISE ENGAGED IN EXPORT,

the products mainly include chemical products, medical devices, masks, machinery, chemical RAW materials, pharmaceutical INTERMEDIates.

We have more and more customers from all over the world. We can provide our customers with the best product quality and reasonable price.

Our aim is "service and sincere exchange for your trust and support, mutual benefit and win-win". We look forward to working with friends all over the world!

In order to meet the requirements of importers and middlemen, further provide customers with "door to door" service.

We have our own export service system, can provide customers with the best export route and the lowest price.
We have a skilled, operational ability of the team.

In addition, we can find the goods with the lowest price and the best quality for overseas customers,

check the goods and reserve shipping space, so as to open up the Chinese market and relieve the import and export.

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ECHEMI Editorial Reference

Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.
Retatrutide (LY-3437943) was discovered by the American pharmaceutical company Eli Lilly and Company. It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors) for obesity. The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her role in developing sustained acting versions of this hormone as a treatment for obesity.

Basic Info

Product Name:

Retatrutide

Other Name:

Retatrutide;GIPR/GLP-1R;LY3437943Retatrutide;Retalutide;Retatrutide (sodium salt);Retatrutide RT5;retatrutide 5mg;Retatratide

CAS No.:

2381089-83-2

InChIKeys:

MLOLQJNKXBNWFW-SAGGEDDASA-N

Molecular Weight:

EC Number:

200-001-8

Color/Form:

White lyophilized

Categories:

Bulk Drug Intermediates

Characteristics

Water Solubility:

Soluble in water (5mg/ml).

Storage Conditions:

-20°C

Critical Temperature & Pressure:

-20°C

Research

Class:

Triple agonist — GCGR, GIPR, GLP-1R

Status:

Investigational (Phase 3)

Mechanism:

Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.

EC50 (Human GCGR):

5.79 nM

EC50 (Mouse GIPR):

0.191 nM

EC50 (Mouse GLP1R):

0.794 nM

EC50 (Mouse GCGR):

2.32 nM

EC50 (Human GLP1R):

0.775 nM

EC50 (Human GIPR):

0.0643 nM

Source:

Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI

Clinical Development:

NCT04881760; NCT05882045; NCT06354660

References

ChEMBL:

DrugBank:

KEGG DRUG:

PubChem:

Literature:

NEJM: Jastreboff et al. (2023) — Phase 2 Trial; FDA Drugs@FDA

Disclaimer:

Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

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Seller Information

Business Type:
Trader

Main Products:
S3,14 bd0

Location:
Room8-18,building156,No.19,26,27,QinglinCommercial Plaza,Haishu District,Ningbo City,Zhejiang Province

Payment Terms:
TT against copy of documents,L/C,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
Less than $1 million

Total Employees:
11-50

Year of Establishment:
2020

Ningbo Henghua Technology Development Co., Ltd. is a company specialized in export. Our main products include pharmaceutical intermediates, food additives, chemical products, and cosmetic raw materials. These products are exported to over 80 countries and regions, including North America, Europe, Singapore, Australia, Russia, Africa, the Middle East, and more. Additionally, we offer product customization services to meet the specific needs of our clients. With a global customer base, we are able to provide the best product quality at competitive prices.

To further meet customer demands and offer "door-to-door" services, we have established our own export service system. This allows us to provide clients with optimal export routes at the lowest possible prices.

Moreover, we have a top-tier R&D team, a professional production team, and a strict quality control department, enabling us to offer overseas clients the best goods at the lowest prices, inspect products, and reserve shipping spaces, thus facilitating the expansion of the Chinese market and eliminating concerns regarding import and export. We also provide patient and attentive after-sales service to assist with any issues during the order process.

By choosing henghua, you will have a reliable partner, high-quality products, fast and secure transportation, and worry-free after-sales support. Our mission is to "earn your trust and support through service and sincerity, achieving mutual benefit and win-win outcomes." We adhere to the management principles of "Quality First, Service First, Continuous Improvement, and Innovation to Satisfy Customers," with a quality goal of "Zero Defects, Zero Complaints." Henghua Technology looks forward to cooperating with friends from all over the world!

Inquiry History

7395 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Retatrutide 2381089-83-2	3 MT	Mar 28, 2026
United Kingdom	Retatrutide - 2381089-83-2	1 G	Feb 10, 2026
United States	Retatrutide CAS 2381089-83-2 10mg vial	20 MT	Mar 7, 2026
United States	Factory Retatrutide API 99% Purity CAS 2381089-83-2	5 KG	Nov 10, 2025
United Kingdom	Peptide powder Retatrutide 99% pure for Body building cas 2381089-83-2 Weight Loss Peptide with COA	1 MT	Mar 22, 2026
United States	2381089-83-2	100 G	Jul 14, 2026
United States	2381089-83-2	100 G	Feb 24, 2026
United States	2381089-83-2	100 MT	Dec 9, 2023
United States	Retatrutide 2381089-83-2	200 MG	May 16, 2026
United Kingdom	2381089-83-2 retatrutide	300 MG	Feb 13, 2026
United States	Retatrutide 2381089-83-2 wholesale	500 MT	Nov 3, 2023
United States	Retatrutide CAS 2381089-83-2 99%	10 PCS	Feb 21, 2026
Austria	Retatrutide CAS 2381089-83-2 10mg vial	20 PCS	Feb 10, 2026
Poland	CAS 2381089-83-2 (Custom Peptide)	40 MT	Apr 10, 2026
Austria	Peptide Retatruide CAS 2381089-83-2	100 MT	Apr 4, 2026
United States	GLP-1 / GIP Retatrutide cas 2381089-83-2	1 MT	Oct 16, 2024
United States	Retatrutide 99% High Quality CAS 2381089-83-2	1 G	Jan 23, 2026
United States	Injection Peptide Tirzepatide/Retatrutide/ Semaglutide Peptides CAS 2381089-83-2	10	Oct 21, 2023
Palestine	Factory 99% Purity Retatrutide Peptide CAS 2381089-83-2 Door-To-Door Service	10 MG	Mar 16, 2026
United States	Factory 99% Purity Retatrutide Peptide CAS 2381089-83-2 Door-To-Door Service	20 MG	Feb 4, 2026

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Retatrutide 99% 2381089-83-2 GLP-1, GIP, and GCGR receptors Peptide

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