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high quality Manufacturer Supply CAS no 5786-21-0 Clozapine Powder

Name: high quality Manufacturer Supply CAS no 5786-21-0 Clozapine Powder
Brand: QSC=Qingdao Baishiwei Chemical
SKU: pr2408301335
Price: 3.15 USD
Availability: InStock

3 Inquiries

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CAS No.:

5786-21-0

Grade:

Pesticide Grade

Content:

99%

Port:

QINGDAO

Brand:

QSC=Qingdao Baishiwei Chemical

Packaging:

25kg drum

Price valid (until):

2025-01-24

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bestway (Shandong) Chemical Co., LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

ghk cu

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Product Description
Seller Information
Inquiry History

Description

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Product Name	Clozapine
CAS	5786-21-0
MF	C18H19ClN4
EINECS	227-313-7
Water Solubility	Soluble to 0.70 mg/ml in water
storage temp	2-8°C
Product specification	1kg/5kg/10kg
form	powder
color	white

Clozapine, 8-chloro-11-(4-methyl-1-piperazinyl)5H-dibenzo[b,e] [1,4] diazepine (Clozaril), is a yellowcrystalline powder that is only slightly soluble in water. Withthe introduction of clozapine, a different pharmacological antipsychotics.106 Unlike typical antipsychotics, clozapine is largelydevoid of EPS. The lack of EPS with this compound waspostulated to be caused by its preferential binding tomesolimbic rather than striatal DA receptors.Furthermore,clozapine was shown to exhibit potent affinity for 5-HT2Areceptors.

DMCZ shows partial agonism at D2 and D3 receptors andexhibits a distinctly different pharmacological profile comparedwith clozapine and other atypical antipsychotics.Unlike clozapine, which is a potent M1 muscarinic antagonist,DMCZ is a potent M1 agonist. Agonism at muscarinicreceptors has been proposed to be useful for impaired cognitionin schizophrenia. Burnstein et al.found thatDMCZ acted as a partial agonist at DA D2 and D3 receptors.These investigators suggested that the low incidence of EPSassociated with clozapine may be caused by the partial agonismof DMCZ at D2 and D3 receptors. Thus, DMCZ maybe of interest as an atypical antipsychotic with an improvedside effect profile compared with clozapine.

Product Name: Clozapine
Synonyms: 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-;LEPONEX;LIPONEX;CLOZAPINE;CLOZARIL;COLZARIL;HF-1854;Asaleptin
CAS: 5786-21-0
MF: C18H19ClN4
MW: 326.82
EINECS: 227-313-7
Melting point: 182-185°C
Boiling point: 482.71°C
Density: 1.1327
Storage temp.: Store at RT
Appearance: Yellow Crystalline Powder

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Superiority

1.High quality and competitive price.
2.Free sample for your evaluation.
3.Promptly delivery by well-reputed shipping lines.
4.We will inform you all the information at every stage in advance.
5.Packaging can gear to buyers’ special request.

Our service

1. Reply your inquiry in 24 working hours.
2. Customized design is available. OEM are welcomed.
3. Exclusive and unique solution can be provided to our customer by our well-trained and professional engineers and
staff.
4. As an honest seller, we always use superior raw material, advanced machines, skilled technicians to ensure our products to be finished in high quality and stable feature.

Why Choose Us?

1. High-concentration products, strictly control the quality.
2. Reasonable and flexible price matched with high quality.
3. Spot samples can be shipped quickly after payment, saving time for receiving goods.
4.Full experience of large numbers containers loading in Chinese sea port.
5. Safe raw materials from China.
6. Have professional customs clearance capabilities and the best after-sales service.

1. Pharmaceutical Expertise:
- With years of experience in the pharmaceutical industry, our team brings extensive expertise in product development, manufacturing, and distribution.
2. High-Quality Products:
- We adhere to stringent quality control standards and Good Manufacturing Practices (GMP) to ensure the safety and efficacy of our pharmaceutical products.
3. Diverse Product Range:
- Our extensive product portfolio includes Active Pharmaceutical Ingredients (APIs), finished dosage forms, pharmaceutical intermediates, and customized pharmaceutical solutions to meet a wide range of needs.
4. Customization Capabilities:
- We offer tailored solutions for pharmaceutical product development and manufacturing to meet the unique requirements of our clients.
5. Global Reach:
- We have a strong international presence, allowing us to serve customers and partners worldwide. Our products are distributed in various regions, ensuring accessibility and reliability.
6. Regulatory Compliance:
- We maintain strict adherence to international regulatory standards and guidelines, ensuring that our products meet all necessary regulatory requirements.
7. Responsive Customer Support:
- Our dedicated customer support team is available to assist you promptly with inquiries, orders, and technical support.
8. Competitive Pricing:
- We strive to provide competitive pricing for our high-quality pharmaceutical products, enabling cost-effective solutions for our clients.
9. Sustainable Practices:
- We are committed to environmentally responsible practices in our manufacturing processes and operations, contributing to a sustainable future.
10. Innovation and Research: - We invest in research and development to stay at the forefront of pharmaceutical advancements and deliver innovative products to our customers.

11. Long-Term Partnerships: - We value long-term relationships with our customers and partners, fostering trust and collaboration for mutual success.

12. Transparent Communication: - We believe in transparent and open communication, ensuring that our clients are informed and confident in their dealings with us.

Basic Info

Product Name:

Clozapine

Other Name:

5H-Dibenzo[b,e][1,4]diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-;8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;HF 1854;Clozapine;Leponex;Clozapin;Iprox;Clozaril;Asaleptin;Azaleptine;Cloril;Fazaclo;Klozapol;Azaleptin;Sizopin;Clozapex;Apo-Clozapine

CAS No.:

5786-21-0

Molecular Formula:

C18H19ClN4

InChIKeys:

InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N

Molecular Weight:

326.82

Exact Mass:

326.82

EC Number:

227-313-7

UNII:

J60AR2IKIC

NSC Number:

757429

DSSTox ID:

DTXSID5022855

NCI Thesaurus Code:

C28936

Color/Form:

Yellow crystals from acetone-petroleum ether

ATC Code:

N05AH02|N - Nervous system

HScode:

2933990090

Categories:

Inhibitors

Characteristics

PSA:

30.9

XLogP3:

3.23

Appearance:

pale yellow

Density:

1.3±0.1 g/cm3

Melting Point:

183-184 °C

Boiling Point:

489.2±55.0 °C at 760 mmHg

Flash Point:

9℃

Refractive Index:

1.681

Water Solubility:

ethanol: 1 mg/mL

Storage Conditions:

Store at RT

Vapor Pressure:

1.12X10-8 mm Hg at 25 deg C (est)

Toxicity:

LD50 in mice, rats (mg/kg): 61, 58 i.v.; 199, 260 orally (Lindt)

PKA:

7.5None

Henrys Law Constant:

Henry's Law constant = 9.29X10-15 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

7.5|pKa = 7.50|pKa1 3.70; pKa2 7.60|pKa1 = 3.92 (imine); pKa2 = 7.75 (amine); pKa3 = 15.90 (secondary amine) (est)

Collision Cross Section:

178.8 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|177.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Hydroxyl radical reaction rate constant = 3.76X10-10 cu cm/molecule-sec at 25 °C (est)

See More Clozapine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Germ cell mutagenicity, Category 2

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H341 Suspected of causing genetic defects H361 Suspected of damaging fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place.

See More Clozapine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
ghk cu

Location:
No. 33688 Jingshi East Road, High-tech Zone, Jinan City, Shandong Province, Jinan Comprehensive Bonded Zone Customs supervision warehouse supporting office area 101-B3

Payment Terms:
100% TT in advance

Average lead Time:
120

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2021

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	Clozapine	25 KG	Oct 30, 2024
Netherlands	Clozapine powder	25 KG	Oct 21, 2024
India	Clofozine	1.00 KG	Feb 20, 2024

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