Efavirenz CAS 154598-52-4
2 Inquiries
154598-52-4
Pharmaceutical Grade
99%
Shanghai
1kg/bag;25kg/Cardboard Drum
Yes
2024-12-31
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceWhite to Slightly Pink Crystalline PowderChEBI: 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor wit activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.Efavirenz D5 was launched as Sustiva in the US for the treatment of infection by HIV, the virus causing AIDS, in combination wi
Solid
Efavirenz is 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection. It has a role as a HIV-1 reverse transcriptase inhibitor and an antiviral drug. It is a benzoxazine, an acetylenic compound, an organochlorine compound, an organofluorine compound and a member of cyclopropanes.|Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.|Efavirenz is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside Reverse Transcriptase Inhibitor, and Cytochrome P450 3A Inducer, and Cytochrome P450 2B6 Inducer, and Cytochrome P450 2C9 Inhibitor, and Cytochrome P450 2C19 Inhibitor, and Cytochrome P450 3A4 Inhibitor.|Efavirenz is a nonnucleoside reverse transcriptase inhibitor used in combination with other agents in the therapy of human immunodeficiency virus (HIV) infection. Efavirenz is associated with a low rate of serum enzyme elevations during therapy and is an uncommon, but well established cause of clinically apparent acute liver injury.|Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism.Basic Info-
Product Name:
Efavirenz
Other Name:2H-3,1-Benzoxazin-2-one,6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-,(4S)-;2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-,(S)-;2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-,(4S)-;(4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one;L 743726;DMP 266;Efavirenz;Sustiva;Stocrin;(-)-Efavirenz;EFV;(S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one;(S)-4-(2-Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one;(S)-4-(Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one;(S)-Efavirenz;(4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
CAS No.:154598-52-4
Molecular Formula:C14H9ClF3NO2
InChIKeys:InChIKey=XPOQHMRABVBWPR-ZDUSSCGKSA-N
Molecular Weight:315.67
Exact Mass:315.67
EC Number:1806241-263-5
UNII:JE6H2O27P8
NSC Number:742403
DSSTox ID:DTXSID9046029
NCI Thesaurus Code:C29027
Color/Form:Crystals from toluene:heptane|White to slightly pink crystalline powder
ATC Code:J05AR06|J05AG03|J - Antiinfectives for systemic use
HScode:2934990002
Categories:
Characteristics-
PSA:
38.3
XLogP3:4.6
Appearance:white to beige
Density:1.53±0.1 g/cm3(Predicted)
Melting Point:139-141 °C
Boiling Point:340.6±42.0 °C(Predicted)
Flash Point:2℃
Refractive Index:1.582
Water Solubility:DMSO: soluble15mg/mL, clear
Storage Conditions:-20°C Freezer
Vapor Pressure:3.8X10-7 mm Hg at 25 deg C (est)
Specific rotation:D20 -84.7° (c = 0.005 g/ml in CH3Cl); D25 -94.1° (c = 0.300 in methanol)
Henrys Law Constant:Henry's Law constant = 7X10-9 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa = 10.2|pKa = 12.52 (amine) (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 4.2X10-11cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P273 Avoid release to the environment.
Response P391 Collect spillage.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Location:
XINYUAN DADUHUI PHASE 1, NO.258 TAOYUAN NORTH ROAD, LIANHU DISTRICT, XI 'AN , SHAANXI CHINA
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Payment Terms:
TT against copy of documents,100% TT in advance
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Average lead Time:
30 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2023
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
India
Efavirenz
5.00 MT Mar 31, 2025 
Brazil
Efavirenz
100 MT Nov 15, 2024 Post an enquiry for this product
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