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TOP SELL sitagliptin

Name: TOP SELL sitagliptin
Brand: DIDEU
SKU: pr2409141306
Price: 1 USD
Availability: InStock

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CAS No.:

486460-32-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

DIDEU

Packaging:

25kg

Price valid (until):

2024-09-14

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Shaanxi Dideu Medichem Co. Ltd

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

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Product Description
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Inquiry History

Description

Sitagliptin Basic information

Description Mechanism of action Pharmacokinetics Indications Clinical Use Side effects Drug interactions

Product Name:	Sitagliptin
Synonyms:	(3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;Sitagliptin;(3R)-3-AMino-1-[3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,2,4-riazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-rifluorophenyl) butan-1-one;(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;Sitagliptin (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;Sitagliptin base;Sitagliptin-D4;Sitagliptin-D4 HCL
CAS:	486460-32-6
MF:	C16H15F6N5O
MW:	407.31
EINECS:	690-730-1
Product Categories:	Heterocycles;Pharmaceutical intermediate;API;486460-32-6
Mol File:	486460-32-6.mol

Sitagliptin Chemical Properties

Melting point	114.1-115.7 °C
Boiling point	529.9±60.0 °C(Predicted)
density	1.61±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : ≥ 50 mg/mL (122.76 mM)
form	Solid
pka	7.20±0.10(Predicted)
color	White to off-white
InChI	InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
InChIKey	MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES	C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F
CAS DataBase Reference	486460-32-6(CAS DataBase Reference)
EPA Substance Registry System	1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- (486460-32-6)

Safety Information

Hazardous Substances Data

486460-32-6(Hazardous Substances Data)

ECHEMI Editorial Reference

Sitagliptin is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts.

Basic Info

Product Name:

Sitagliptin

Other Name:

1-Butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-,(3R)-;1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-;(3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone;(2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine;Sitagliptin;3(R)-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine;(3R)-3-Amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;(3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;Xelevia;Tesavel;Ristaben

CAS No.:

486460-32-6

Molecular Formula:

C16H15F6N5O

InChIKeys:

InChIKey=MFFMDFFZMYYVKS-SECBINFHSA-N

Molecular Weight:

407.32

Exact Mass:

407.31

EC Number:

1308068-626-2

Categories:

Other Chemical Drugs

Characteristics

PSA:

XLogP3:

1.5

Appearance:

Solid

Density:

1.6±0.1 g/cm3

Melting Point:

114.1-115.7 °C

Boiling Point:

529.9±60.0 °C at 760 mmHg

Flash Point:

274.3±32.9 °C

Refractive Index:

1.590

Water Solubility:

3.40e-02 g/L

Storage Conditions:

Store at 20-25 deg C (68-77 deg F), excursions permitted to 15-30 deg C (59-86 deg F).

Vapor Pressure:

2.91X10-8 mm Hg at 25 deg C (est)

See More Sitagliptin Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Serious eye damage, Category 1

Specific target organ toxicity â repeated exposure, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H318 Causes serious eye damage H373 May cause damage to organs through prolonged or repeated exposure
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P319 Get medical help if you feel unwell.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Sitagliptin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

Location:
https://www.dideu.com/en/

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
Above $100 million

Total Employees:
Above 1000

Year of Establishment:
2016

Company Certificates
- ISO Certificate
- REACH
Company Profile
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Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	sitagliptin	1 KG	Sep 14, 2024
Oman	Sitagliptin	1 KG	Sep 20, 2026

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TOP SELL sitagliptin

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