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High Quality 99% Sitagliptin CAS 486460-32-6 Powder

Name: High Quality 99% Sitagliptin CAS 486460-32-6 Powder
Brand: Wuhan pnq
SKU: pr2603241681
Price: 10.61 USD
Availability: InStock

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Unit Price:

$10.61-11.67/MT FOB

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CAS No.:

486460-32-6

Grade:

Chemical Grade

Content:

99%

Port:

shanghai

Brand:

Wuhan pnq

Packaging:

Aluminum foil bag

Price valid (until):

2026-11-09

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Wuhan Pnq Int Trade Co., Ltd

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

30 days

Qualification:

Main Products:

Apigenin,PQQ,NMNH

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Seller Information
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Description

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Q1: What's your MOQ?

A:It depends on different products,we can accept sample order or provide free sample for your test.

Q2:How about delivery leadtime?

A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q3: Is there a discount?

A:Different quantity has different discount.

Q4:How to start orders or make payments?

A:Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T or Bitcoin.

Q5: How do you treat quality complaint?

A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q6:We don't know you at all, how can we trust you?

A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.Commitment is the No.1 Point of our Enterprise's Value.

Q7:Do you test all your goods before delivery?

A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.

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Description

Name	Sitagliptin
CAS number	486460-32-6
Synonym	Sitagliptin; LEZ 763; LEZ-763; LEZ763; MK0431; MK 0431; MK-0431;
Description	Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses.
Structure
Molecular Formula	C16H15F6N5O
Molecular Weight	407.31 g/mol
Appearance	White powder
Quality Standard	99%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 2~8 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag, Bottle
Commercial package	Aluminium Tin
Origin	China

Sitagliptin More Info

Sitagliptin is an oral medication used in the management of type 2 diabetes mellitus. It belongs to a class of drugs known as DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors), which are designed to improve glycemic control by enhancing the body ’ s own ability to lower blood sugar levels.

Mechanism of Action

Sitagliptin works by inhibiting the enzyme DPP-4, which is responsible for breaking down incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory polypeptide). Incretins are hormones that stimulate insulin secretion from the pancreas in response to food intake and also suppress glucagon release, leading to decreased liver glucose production. By preventing the breakdown of these hormones, sitagliptin increases their levels in the bloodstream, promoting insulin secretion and lowering blood glucose levels during and after meals.

Indications

Sitagliptin is indicated for:

Type 2 Diabetes Mellitus: It is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes, either as monotherapy or in combination with other antidiabetic agents, including metformin, sulfonylureas, or thiazolidinediones.

Dosage and Administration

Sitagliptin is typically administered once daily, with or without food. The standard starting dose is 100 mg per day. For patients with moderate renal impairment (creatinine clearance of 30 to 50 mL/min), the recommended dose is 50 mg once daily, and for those with severe renal impairment (creatinine clearance less than 30 mL/min), the dose is reduced to 25 mg once daily.

ECHEMI Editorial Reference

Sitagliptin is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts.

Basic Info

Product Name:

Sitagliptin

Other Name:

1-Butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-,(3R)-;1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-;(3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone;(2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine;Sitagliptin;3(R)-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine;(3R)-3-Amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;(3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;Xelevia;Tesavel;Ristaben

CAS No.:

486460-32-6

Molecular Formula:

C16H15F6N5O

InChIKeys:

InChIKey=MFFMDFFZMYYVKS-SECBINFHSA-N

Molecular Weight:

407.32

Exact Mass:

407.31

EC Number:

1308068-626-2

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

1.5

Appearance:

Solid

Density:

1.6±0.1 g/cm3

Melting Point:

114.1-115.7 °C

Boiling Point:

529.9±60.0 °C at 760 mmHg

Flash Point:

274.3±32.9 °C

Refractive Index:

1.590

Water Solubility:

3.40e-02 g/L

Storage Conditions:

Store at 20-25 deg C (68-77 deg F), excursions permitted to 15-30 deg C (59-86 deg F).

Vapor Pressure:

2.91X10-8 mm Hg at 25 deg C (est)

See More Sitagliptin Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Serious eye damage, Category 1

Specific target organ toxicity â repeated exposure, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H318 Causes serious eye damage H373 May cause damage to organs through prolonged or repeated exposure
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P319 Get medical help if you feel unwell.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Sitagliptin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Apigenin,PQQ,NMNH

Location:
Room 1006, Building C6, Economic Development Wanda, Caidian District, Wuhan City, Hubei Province

Payment Terms:
100% TT in advance

Average lead Time:
30 days

Total Annual Revenue:
Less than $1 million

Total Employees:
5-10

Year of Establishment:
2021

Wuhan PNQ trade located in Wuhan, China, is an innovative natural products manufacturer and supplier that offers raw powders as dietary ingredients, food and beverage additives, sports nutrition supplements.
Weekly Price

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Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Oman	Sitagliptin	1 KG	Sep 20, 2026
United States	sitagliptin	1 KG	Sep 14, 2024

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High Quality 99% Sitagliptin CAS 486460-32-6 Powder

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