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API Ketoconazole CAS 65277-42-1

Name: API Ketoconazole CAS 65277-42-1
Brand: Hyper Chem
SKU: pr2409241687
Price: 130 USD
Availability: InStock

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CAS No.:

65277-42-1

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum,25kg/Drum

Sample Available:

Yes

Price valid (until):

2024-10-24

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Ketoconazole
CAS number	65277-42-1
Synonym	Nizoral, Kuric, Fungoral, Ketoderm, Xolegel, Extina
Description	Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.Label It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.5,11 Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981.9 At this time it was considered a significant improvement over previous antifungals, miconazole and clotrimazole, due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.9,10 These effects combined with waning efficacy led to its eventual replacement by triazole agents, fluconazole, itraconazole, voriconazole, and posaconazole. Ketoconazole and its predecessor clotrimazole continue to be used in topical formulations.
Structure
Molecular Formula	C₂₆H₂₈Cl₂N₄O₄
Molecular Weight	531.431
Appearance	White to off-white crystalline powder.
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

ECHEMI Editorial Reference

Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.Target: CYP3A4 CYP24A1Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections [1]. Ketoconazole also is a cytochrome P450 inhibitor [2].Ketoconazole (KTZ), on the antischistosomal potential of these quinolines against

Certificates

Basic Info

Product Name:

Ketoconazole

Other Name:

Ethanone,1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-,rel-;Piperazine,1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-,cis-;Piperazine,1-acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-,rel-;rel-1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone;Ketoconazole;R 41400;Nizoral;(±)-Ketoconazole;Fungoral;Nizral;Orifungal M;Ketoderm;Panfungol;Ketoisdin;Fungarest;Brizoral;Onofin K;Ketozoral;Phytorol;Tocon;Nizaral;Micosin;72093-26-6

CAS No.:

65277-42-1

UN No.:

2811

Molecular Formula:

C26H28Cl2N4O4

InChIKeys:

InChIKey=XMAYWYJOQHXEEK-MKNUCDGGNA-N

Molecular Weight:

531.43100

Exact Mass:

531.43

HScode:

2933990090

Categories:

Antibiotics

Characteristics

PSA:

69.06000

XLogP3:

4.20870

Appearance:

white to off white crystalline powder

Density:

1.38g/cm3

Melting Point:

146 °C

Boiling Point:

753.4ºC at 760 mmHg

Flash Point:

409.4ºC

Refractive Index:

1.642

Water Solubility:

Soluble in DMSO, ethanol, chloroform, water, and methanol.

Storage Conditions:

2-8ºC

Toxicity:

LD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel)

See More Ketoconazole Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Specific target organ toxicity â repeated exposure, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H373 May cause damage to organs through prolonged or repeated exposure H410 Very toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P319 Get medical help if you feel unwell. P391 Collect spillage. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Well closed. Separated from food and feedstuffs. Store in an area without drain or sewer access.Store at controlled room temperature 15 deg - 25 deg C (59 deg - 77 deg F). Protect from moisture.

See More Ketoconazole Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

23 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	KETOCONAZOLE	50 KG	Dec 25, 2024
United Kingdom	Ketoconazole	1 KG	May 31, 2026
Sri Lanka	Ketoconazole Powder	10 KG	Feb 20, 2025
United Kingdom	99% Raw Pharmaceutical Raw Material Ketoconazole for Shampoo Nizoral	1 KG	Aug 31, 2024
India	ketoconazol	500 KG	Feb 6, 2024
Poland	Ketoconazole	10 KG	Oct 9, 2023
Sri Lanka	Ketakenazole	1 KG	Mar 18, 2026
United States	ketoconazole	100 KG	Oct 24, 2025
Pakistan	Ketoconazole	1 KG	Jul 3, 2025
Bangladesh	Ketoconazole	1 KG	Nov 27, 2024
New Zealand	Ketoconazole 99% powder	2 KG	Oct 2, 2024
Ecuador	Ketoconazol	0.50 KG	Jul 26, 2024
Australia	Ketoconazole	1 MT	May 27, 2024
Cameroon	Ketoconazole powder 99% white wholesale	1 KG	Feb 5, 2024
Sri Lanka	Ketoconazole powder 99% White Powder	10 KG	Nov 6, 2023
Paraguay	Almidon pre-gelatinizado	300.00 KG	Dec 1, 2025
Paraguay	Ceftiofur hcl	25.00 KG	Dec 1, 2025
Paraguay	Dichloromethane	5000.00 KG	Dec 1, 2025
Paraguay	Pyrantel pamoate	75.00 KG	Dec 1, 2025
Paraguay	Azepromacine maleate	12.00 KG	Dec 1, 2025

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API Ketoconazole CAS 65277-42-1

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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