PROPYLENE GLYCOL 57-55-6

Propylene glycol

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57-55-6

C3H8O2

DNIAPMSPPWPWGF-UHFFFAOYSA-N

76.09

1340498

200-338-0

TSCA listed

APHA: ≤10

29053200

Synthetic Fragrances

1.036 g/mL at 25 °C (lit.)

-60 °C (lit.)

187 °C (lit.)

n20/D1.432(lit.)

miscible

0.08 mm Hg ( 20 °C)

2.62 (vs air)

Propylene glycol has a low degree of toxicity in animals as well as humans, such that very high doses are needed to elicit effects in acute toxicity studies. The toxic effects of propylene glycol appear to be similar in animals and in humans. Central nervous system (CNS) depression, hematologic toxicity, hyperosmolarity, metabolic acidosis, cardiovascular effects, and renal toxicity encompass the main acute and subacute syndromes for propylene glycol. Most of the effects of propylene glycol can be ascribed to high concentrations of the parent molecule or to the accumulation of D,L-lactate in the blood. Due to its alcohol moiety, propylene glycol at very high concentrations is the most likely reason for the CNS depression. Also, because high concentrations of propylene glycol will increase the osmolarity of the blood, the hyperosmotic effects are likely due to the parent molecule. The cardiovascular and renal effects may be a result of the hyperosmolarity in combination with the metabolic acidosis. The acidosis itself results from the accumulation of lactate (both D- and L-forms), which has been well documented in both animals and humans.

at 100.00 %. odorless very slight alcoholic

6-8 (100g/l, H2O, 20℃)

14.49±0.20(Predicted)

2.7×103mol/(m3Pa) at 25℃, Burkholder et al. (2019)

Water soluble.

1,2-Propanediol is hygroscopic. 1,2-Propanediol is sensitive to excessive heat (tends to oxidize at high temperatures). 1,2-Propanediol can react with oxidizing materials. 1,2-Propanediol is incompatible with acid chlorides, acid anhydrides, chloroformates, and reducing agents. 1,2-Propanediol dissolves many essential oils. A mixture of 1,2-Propanediol with hydrofluoric acid and silver nitrate was put in a glass bottle which burst 30 minutes later.

779 °F

Store at +5°C to +30°C.