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Propylene Glycol

Propylene Glycol structure

CAS No:
57-55-6
Chemical Name:
Propylene Glycol
Synonyms:
1,2-Propanediol;PG 12;1,2-Dihydroxypropane;Methylethylene glycol;Monopropylene glycol;Propylene glycol;α-Propylene glycol;1,2-Propylene glycol;Sirlene;2,3-Propanediol;Methylethyl glycol;2-Hydroxypropanol;Isopropylene glycol;Solar Winter Ban;Ucar 35;Solargard P;Dowfrost;1000PG;DL-1,2-Propanediol;dl-Propylene glycol;(±)-Propylene glycol;(±)-1,2-Propanediol;(RS)-1,2-Propanediol;1,2-(RS)-Propanediol;NSC 69860;Adeka Propylene Glycol PG-P;PG-T (glycol);PG-T;Adeka PG;ProGlyc 55;Safewing MP-I 1938;Safewing MP-IV 2001;DC 403;Nybrine NFP;Kilfrost ABC-S;Propyless;Kollisolv PG;HCH 195;Susterra PDO;Kilfrost ABC K Plus;Kilfrost DF K Plus;BS 12;Radianol 4713;Radianol 4710;4254-16-4;63625-56-9;190913-75-8;1194046-20-2
Categories:
Cosmetic Ingredient > Dissolving Agent

Description

(±)-1,2-Propanediol is an aliphatic alcohol and frequently used as an excipient in many drug formulations to increase the solubility and stability of drugs.

Propylene Glycol Basic Attributes

Molecular Weight：

76.09440

Exact Mass：

76.09

EC Number：

939-872-0

HScode：

2905320000

Characteristics

PSA：

40.46000

XLogP3：

-0.9

Appearance：

Clear viscous liquid

Density：

1.036 g/cm³ @ Temp: 25 °C

Melting Point：

-59 °C

Boiling Point：

188.2 °C

Flash Point：

99ºC

Refractive Index：

n20/D 1.432(lit.)

Water Solubility：

Solubility in water: miscible

Storage Conditions：

Store at RT.

Vapor Pressure：

Vapour pressure, Pa at 20°C: 10.6

Vapor Density：

2.62

Toxicity：

LD50 orally in Rabbit: 19400 - 36000 mg/kg LD50 dermal Rabbit 20800 mg/kg

Flammability characteristics：

Lower flammable limit: 2.6% by volume; Upper flammable limit: 12.5% by volume

Explosive limit：

Explosive limits , vol% in air: 2.6-12.6

Odor：

Practically odorless

Taste：

Practically tasteless

PKA：

14.9None

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

S24/25

RTECS Number：

TY2000000

Storage features：

Separated from strong oxidants and alkalis. Dry. Well closed. Ventilation along the floor.

Stability/Shelf Life：

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.

Precautionary statement(s)：

P264, P270, P273, P280, P301+P312, P305+P351+P338, P330, P337+P313, P391, P501

Hazard Statements：

H302

Propylene Glycol Use and Manufacturing

Propylene glycol has good solubility and less toxicity and irritation, and is widely used as solvents, extraction solvents and preservatives for injections (eg. intramuscular injections, intravenous injections) and non-injectable pharmaceutical preparations (such as oral liquid, ophthalmic preparations, otic preparations, dental preparations, rectovaginal preparations, transdermal preparations, etc.). It is better than glycerol solvent and can dissolve many substances such as corticosteroids (sex hormone), chloramphenicol, sulfonamides, barbiturate, reserpine, quinidine, corticosterone acetate, tetrahydropalmatine sulfate, mechlorethamine hydrochloride, vitamin A, vitamin D, many volatile oils, most of the alkaloids and many local anesthetics. Propylene glycol is similar to ethanol when used as a bacteriostatic agent, and its efficacy to inhibit mold is similar to glycerin and is slightly lower than that of ethanol. Propylene glycol is commonly used as a plasticizer for the aqueous film coating materials. Its mixture with equal amounts of water can delay the hydrolysis of certain drugs, and increase the stability of the preparation product. It is used as an antimicrobial preservative in 15% to 30% propylene glycol solution and semi-solid formulation, as humectants in about 15% propylene glycol topical formulation, and as solvent and co-solvent in 10% to 30% propylene glycol aerosol solvent, 10% to 25 % propylene glycol oral solution, 10% to 60% injectable formulation and 5% to 80% topical formulation.

Computed Properties

Molecular Weight:76.09
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:76.052429494
Monoisotopic Mass:76.052429494
Topological Polar Surface Area:40.5
Heavy Atom Count:5
Complexity:20.9
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ethylene glycol

Propylene carbonate

Carbon dioxide

Ethyl acrylate

Sorbitol

Glucose

Glycerol

Acetic acid

Propane

Silicon

Propylene Oxide

tert-Butanol

Hydrogen peroxide

3-Chloro-1,2-propanediol

Downstream Products

Ethylene glycol

Propylene carbonate

Dimethoxymethane

Sodium formate

Formaldehyde

Benzimidazole

Ethanol

Formic acid

Acetic acid

Methanol

Isopropanol

Acetone

1-Propanol

Acetaldehyde

Propylene Oxide

Methyl acrylate

Price Analysis

Make your Propylene Glycol purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Propylene Glycol prices .

Data: 2026-07-28
Price: 9366.67Yuan/mt
Change: 233.33

Drug Function and Efficacy

Siran eye drops are high molecular polymers with hydrophilicity and film-forming properties. At appropriate concentrations, they can play a role similar to artificial tears.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Polyethylene glycol eye drops
Ingredients	The main ingredients of Siran eye drops are: polyethylene glycol; propylene glycol
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Per ml: polyethylene glycol 4 mg; propylene glycol 3 mg

EQUALINE LUBRICANT EYE DROPS- polyethylene glycol 400, propylene glycol_solution/ drops
Manufacturer	United Natural Foods, Inc.

Polyethylene glycol eye drops
Ingredients	The main ingredients of Siran eye drops are: polyethylene glycol; propylene glycol
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Per ml: polyethylene glycol 4 mg; propylene glycol 3 mg

See More Related Drugs

Registered Holders

CNOOC and Shell Petrochemicals Company Limited

China
Active
Dow Chemical (China) Investment Co., Ltd. Shanghai Branch

China
Active
Shanghai Slg Cro Co., Ltd.

China
Active

See More Registered Holders

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