Supply High Quality Sodium 99% USP Cromoglycate Anti-allergic Powder Cromolyn Sodium CAS 15826-37-6

Cromolyn Sodium More Info

Cromolyn sodium, also known as sodium cromoglycate, is a medication primarily used as a mast cell stabilizer. It is effective in preventing the release of inflammatory mediators such as histamine from mast cells, making it useful in treating various allergic conditions. Cromolyn sodium has been available since the 1970s and is commonly used for managing asthma, allergic rhinitis, and mastocytosis, among other conditions.

Mechanism of Action

Cromolyn sodium works by stabilizing mast cell membranes, thereby inhibiting the degranulation process that leads to the release of histamine and other inflammatory mediators. This action prevents both immediate and late-phase allergic reactions. Unlike antihistamines, which block the effects of histamine after it has been released, cromolyn sodium acts to prevent its release altogether .The drug may also reduce bronchial hyperreactivity and inhibit calcium influx into mast cells, further contributing to its stabilizing effects

Applications

Cromolyn sodium is used in various clinical settings:
1. Asthma: It is effective for prophylactic treatment of both allergic and exercise-induced asthma but is not suitable for acute attacks.
2. Allergic Rhinitis: It helps manage symptoms such as sneezing and nasal congestion.
3. Allergic Conjunctivitis: Used in ophthalmic solutions to treat eye allergies.
4. Mastocytosis: It alleviates symptoms caused by excessive mast cell activity, including abdominal pain and skin reactions

Routes of Administration

Cromolyn sodium can be administered through various routes:
Inhalation: Typically used for asthma management.
Nasal Spray: Commonly used for allergic rhinitis.
Ophthalmic Drops: Used to treat allergic conjunctivitis.
Oral Solution: Prescribed for systemic conditions like mastocytosis

Safety and Side Effects

Cromolyn sodium is generally well-tolerated with a low incidence of serious side effects. Common adverse effects include:
Mild gastrointestinal disturbances (nausea, vomiting)
Headaches
Flushing
Local irritation at the site of administration (nasal or ocular)
Severe reactions are rare, making it a safe option for long-term management of allergic conditions

Pharmacokinetics

Cromolyn sodium exhibits poor absorption when taken orally, with less than 0.07% bioavailability from nasal or ophthalmic forms. Its half-life ranges from 80 to 90 minutes, with effects lasting approximately six hours post-administration. Most of the drug is excreted unchanged through feces.

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FAQ

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We can send you a samll free sample, and you only need to pay for the shipping cost.

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