Cromolyn Disodium Salt
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Cromolyn Disodium Salt
structure -
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CAS No:
15826-37-6
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Formula:
C23H17NaO11
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Chemical Name:
Cromolyn Disodium Salt
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Synonyms:
DSCG;disodium 5,5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4h-1-benzopyran-2-carboxylate];disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol;CROMOGLYCATE SODIUM SALT;CROMOGLYCIC ACID SODIUM SALT;CROMOLYN SODIUM SALT;sodium 5-[3-[(2-carboxy-4-oxo-1-benzopyran-5-yl)oxy]-2-hydroxypropoxy]-4-oxo-1-benzopyran-2-carboxylic acid;4h-1-benzopyran-2-carboxylicacid,5,5’-((2-hydroxytrimethylene)dioxy)bis(4-oxo
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CAS No:
Description
Disodium cromoglycate, white to off-white powder, soluble in water, practically insoluble in ethanol. It is an organic sodium salt, the disodium salt of cromoglycic acid, with a molecular weight of 512.33, a melting point of 241-242°C, a boiling point of 752.3 °C, and a flash point of 263.9°C. Disodium cromoglycate is a compound that blocks the release of pro-inflammatory mediators, preventing the release of histamine, leukotrienes, and cytokines from mast cells. It does this by binding to calcium channels on the mast cell membrane, thereby preventing the influx of calcium ions necessary for the release of histamine and other mediators. It has also been found to reduce the expression of adhesion molecules and chemokines involved in inflammatory responses.
Disodium cromoglycateis a relatively nontoxic agent used for the long-term prevention of many types of asthma. It has no bronchodilator properties and is used in the prophylaxis of asthma. It does not play a role in the treatment of acute asthmatic attacks including severe asthma.
White Crystalline Powder
ChEBI: An organic sodium salt that is the disodium salt of cromoglycic acid.
Cromolyn sodium, disodium 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane (Intal), isa hygroscopic, white, hydrated crystalline powder that is solublein water (1:10). It is tasteless at first but leaves a veryslightly bitter aftertaste. The pK of cromolyn is 2. It is availableas a solution for a nebulizer, an aerosol spray, a nasal solution,an ophthalmic solution, and an oral concentrate.Nebulized and aerosol cromolyn has been used for prophylacticmanagement of bronchial asthma and prevention ofexercise-induced bronchospasm. Cromolyn nasal solution isused for the prevention and treatment of allergic rhinitis, andoral concentrate is used to treat the histaminic symptomsof mastocytosis (diarrhea, flushing, headaches, vomiting, urticaria,abdominal pain, nausea, and itching). Topical cromolyn(eye drops) is used to treat allergic conjunctivitis andkeratitis. In the treatment of asthma, cromolyn efficacy is manifestedby decreased severity of clinical symptoms, or need for concomitant therapy, or both. Long-term use is justified if thedrug significantly reduces the severity of asthma symptoms;permits a significant reduction in, or elimination of, steroiddosage; or improves management of those who have intolerableside effects to sympathomimetic agents or methylxanthines.For cromolyn to be effective, it must be administered atleast 30 minutes prior to antigen challenge and administered atregular intervals (see dosing information that follows). Wheninhaled, the powder does produce irritation in some patients.Also, overuse of cromolyn can result in tolerance.
Cromolyn Disodium Salt Basic Attributes
492.37
512.033142
239-926-7
Q2WXR1I0PK
DTXSID7044554
C28946
White to Off-White
29329990
Characteristics
172
241-2420C (dec)
752.3°C at 760 mmHg
263.9ºC
Soluble in water to 100mg/ml
Refrigerator, Under Inert Atmosphere
LD50 in mice, rats (mg/kg): >8000 orally (Cox)
205.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
2-8°C
Safety Information
III
6.1(b)
3249
2
Xi
26-36
DJ2380000
Xi
Store at RT
Hygroscopyc
P305 + P351 + P338
36/37/38
3249
|Warning|H315 (97.67%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)|Compounds that prevent the release of inflammatory mediators from MAST CELLS. (See all compounds classified as Mast Cell Stabilizers.)
Aarane
Cromolyn Disodium Salt Use and Manufacturing
2, 6-Dihydroxyacetophenone is obtained from resorcinol through cyclization, acetylation, rearrangement, and hydrolysis, which is then condensed with epichlorohydrin to form 1, 3-bis(2-acetyl-3 -Hydroxyphenoxy)-2-hydroxypropane, then cyclized with diethyl oxalate and sodium ethoxide to obtain ethyl cromolyn, and finally formed into salt with sodium bicarbonate, decolorized by activated carbon, and recrystallized from ethanol to obtain sodium cromolyn Finished product.
Chromone complex which blocks mast cell degranulation This product is an anti-allergic drug. It has a good effect on allergic asthma. It can still be used for allergic rhinitis or ulcerative colitis.
antiasthmatic, antiallergy
Anti Asthamatic
Chromone complex which blocks mast cell degranulation
Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:512.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:6
Exact Mass:512.03314982
Monoisotopic Mass:512.03314982
Topological Polar Surface Area:172
Heavy Atom Count:36
Complexity:824
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Stabilize mast cell membranes, stop mast cells from releasing allergenic mediators such as histamine, leukotrienes, 5-hydroxytryptamine, bradykinin and slow-reacting substances, thereby preventing the occurrence of allergic reactions
Registered Holders
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MICRO LABS LTD
Active
United States
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Beijing Jingfeng Pharmaceutical (Shandong) Co., Ltd.
Active
China
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Guangzhou Greensyn Pharma Co., Ltd.
Active
China
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