Facory Supply raw material Maraviroc powder CAS 376348-65-1 and Maraviroc price
376348-65-1
Pharmaceutical Grade
99%
shenzhen
1kg/bag;25kg/Cardboard Drum
2024-12-12
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceMaraviroc is a selective CCR5 antagonist with activity against human HIV.
Solid
Maraviroc is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4,4-difluorocyclohexanecarboxylic acid and the primary amino group of (1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylamine. An antiretroviral drug, it prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells. It has a role as an antiviral drug, a chemokine receptor 5 antagonist and a HIV fusion inhibitor. It is an azabicycloalkane, an organofluorine compound, a member of triazoles and a monocarboxylic acid amide.|Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. It was approved for use by the FDA in August, 2007.|Maraviroc is a CCR5 Co-receptor Antagonist. The mechanism of action of maraviroc is as a Chemokine Co-receptor 5 Antagonist.|Maraviroc is a chemokine co-receptor 5 (CCR5) antagonist, the first of a new class of agents active against the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS). Maraviroc was approved for use in the United States in 2007 but has had limited use. Maraviroc has been associated with elevations in serum aminotransferase levels and to several cases of acute, clinically apparent liver injury.|Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist with activity against human immunodeficiency virus (HIV). Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction.|A cyclohexane and triazole derivative that acts as an antagonist of the CCR5 RECEPTOR. It prevents infection by HIV-1 virus strains which use CCR5 as a co-receptor for membrane fusion and cellular entry.Basic Info-
Product Name:
Maraviroc
Other Name:Cyclohexanecarboxamide,4,4-difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-;4,4-Difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide;Maraviroc;UK 427857;Celsentri;Selzentry;4,4-Difluoro-N[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide;674782-29-7
CAS No.:376348-65-1
Molecular Formula:C29H41F2N5O
InChIKeys:InChIKey=GSNHKUDZZFZSJB-QYOOZWMWSA-N
Molecular Weight:513.67
Exact Mass:513.67
EC Number:1592732-453-0
UNII:MD6P741W8A
DSSTox ID:DTXSID8048949
NCI Thesaurus Code:C73144
Color/Form:White solid from toluene/hexane (2:1)|White- to pale-colored powder
ATC Code:J05AX09|J - Antiinfectives for systemic use
HScode:2934999090
Categories:
Characteristics-
PSA:
63
XLogP3:5.1
Appearance:Brown Solid
Density:1.3±0.1 g/cm3
Melting Point:197-198 °C @ Solvent: Toluene, Hexane
Refractive Index:1.628
Water Solubility:DMSO: >30mg/mL
Storage Conditions:Store at +4°C
Vapor Pressure:1.09X10-11 mm Hg at 25 deg C (est)
Henrys Law Constant:Henry's Law constant = 9.49X10-15 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa = 7.3
Experimental Properties:Highly soluble across the physiological pH range (pH 1.0 to 7.5)|Hydroxyl radical reaction rate constant = 8.27X10-11 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Specific target organ toxicity â repeated exposure, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H373 May cause damage to organs through prolonged or repeated exposure
H412 Harmful to aquatic life with long lasting effects
Precautionary statement(s) Prevention P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
Response P319 Get medical help if you feel unwell.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Location:
XINYUAN DADUHUI PHASE 1, NO.258 TAOYUAN NORTH ROAD, LIANHU DISTRICT, XI 'AN , SHAANXI CHINA
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Payment Terms:
TT against copy of documents,100% TT in advance
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Average lead Time:
30
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2023
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
