High Cost Performance Grapiprant 415903-37-6
415903-37-6
Pharmaceutical Grade
99%
Shanghai
G/KG
2024-12-13
Peptides,Chemicals,API,Additives
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Product Description
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Seller Information
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DescriptionGrapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic acid known to be prostaglandin receptor antagonists. This type of molecules is currently in development for veterinary patients. This class of drugs was defined in 2013 by the World Health Organization. Grapiprant has been approved in March 2016 by the FDA's Center for Veterinary Medicine as a non-cyclooxygenase inhibiting NSAID for veterinary use.|Grapiprant is an orally bioavailable antagonist of the prostaglandin E receptor subtype 4 (EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration of grapiprant, this agent selectively binds to and inhibits the binding of prostaglandin E2 (PGE2) and prevents the activation of the EP4 receptor. This inhibits PGE2-EP4 receptor-mediated signaling and prevents proliferation in tumor cells in which the PGE2-EP4 signaling pathway is over-activated. In addition, EP4 receptor inhibition modulates the immune system by preventing both interleukin-23 (IL-23) production and the IL-23-mediated expansion of Th17 cells. As EP4 is expressed by peripheral sensory neurons, blockade of EP4-mediated signaling may induce an analgesic effect. EP4, a prostanoid receptor subtype, is a G protein-coupled receptor that is expressed in certain types of cancers; it promotes tumor cell proliferation and invasion.Basic Info
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Product Name:
Grapiprant
Other Name:Benzenesulfonamide,N-[[[2-[4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino]carbonyl]-4-methyl-;N-[[[2-[4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino]carbonyl]-4-methylbenzenesulfonamide;2-Ethyl-4,6-dimethyl-1-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-1H-imidazo[4,5-c]pyridine;CJ 023423;AAT 007;RQ 00000007;Grapiprant;RQ 7;MR 10A7;1-[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea;Galliprant
CAS No.:415903-37-6
Molecular Formula:C26H29N5O3S
InChIKeys:InChIKey=HZVLFTCYCLXTGV-UHFFFAOYSA-N
Molecular Weight:491.6
Exact Mass:491.61
UNII:J9F5ZPH7NB
DSSTox ID:DTXSID60194419
NCI Thesaurus Code:C124131
ATC Code:QM01AX92
Categories:
Characteristics-
XLogP3:
4.56
Melting Point:>136 ºC (Grapiprant hydrochloride)
Water Solubility:Insoluble
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Seller Information
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Business Type:
Trader
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Main Products:
Peptides,Chemicals,API,Additives
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Location:
Xinbei District,Changzhou City,Jiangsu Province.
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A
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Average lead Time:
15
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
11-50
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Year of Establishment:
2012
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
