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API Choline Chloride CAS 67-48-1

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CAS No.:

67-48-1

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2024-12-05

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Choline chloride
CAS number	67-48-1
Synonym	Bilineurine 、 N-trimethylethanolamine 、 N,N,N-trimethylethanol-ammonium Trimethylethanolamine 、 Vitamin J
Description	Choline is a nutrient found in a wide variety of vitamins including pre-natal formulations. A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Structure
Molecular Formula	C₅H₁₄NO
Molecular Weight	104.1708
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Choline chloride More Info

Choline is a nutrient found in a wide variety of vitamins including pre-natal formulations.

Pharmacodynamics

This compound is needed for good nerve conduction throughout the CNS (central nervous system) as it is a precursor to acetylcholine (ACh). Choline is also needed for gallbladder regulation, liver function and lecithin (a key lipid) formation. Choline also aids in fat and cholesterol metabolism and prevents excessive fat build up in the liver. Choline has been used to mitigate the effects of Parkinsonism and tardive dyskinesia. Choline deficiencies may result in excessive build-up of fat in the liver, high blood pressure, gastric ulcers, kidney and liver dysfunction and stunted growth.

Mechanism of action

Choline is a major part of the polar head group of phosphatidylcholine. Phosphatidylcholine's role in the maintenance of cell membrane integrity is vital to all of the basic biological processes: information flow, intracellular communication and bioenergetics. Inadequate choline intake would negatively affect all these processes. Choline is also a major part of another membrane phospholipid, sphingomyelin, also important for the maintenance of cell structure and function. It is noteworthy and not surprising that choline deficiency in cell culture causes apoptosis or programmed cell death. This appears to be due to abnormalities in cell membrane phosphatidylcholine content and an increase in ceramide, a precursor, as well as a metabolite, of sphingomyelin. Ceramide accumulation, which is caused by choline deficiency, appears to activate Caspase, a type of enzyme that mediates apoptosis. Betaine or trimethylglycine is derived from choline via an oxidation reaction. Betaine is one of the factors that maintains low levels of homocysteine by resynthesizing L-methionine from homocysteine. Elevated homocysteine levels are a significant risk factor for atherosclerosis, as well as other cardiovascular and neurological disorders. Acetylcholine is one of the major neurotransmitters and requires choline for its synthesis. Adequate acetylcholine levels in the brain are believed to be protective against certain types of dementia, including Alzheimer's disease.

Certificates

Basic Info

Product Name:

Choline chloride

Other Name:

Ethanaminium,2-hydroxy-N,N,N-trimethyl-,chloride (1:1);Choline,chloride;Ethanaminium,2-hydroxy-N,N,N-trimethyl-,chloride;Biocolina;Hepacholine;(2-Hydroxyethyl)trimethylammonium chloride;Lipotril;Cholinium chloride;(β-Hydroxyethyl)trimethylammonium chloride;Bilineurin chloride;Luridin chloride;Biocoline;Hormocline;Neocolina;Paresan;Trimethyl(2-hydroxyethyl)ammonium chloride;Actiron CC 6;Choline chloride;Norcol 25;COL 24;ReaShure Choline;Claytreat;(2-Hydroxyethyl)trimethylazanium chloride;1643859-93-1;2028303-08-2

CAS No.:

67-48-1

Molecular Formula:

C5H14NO.Cl

InChIKeys:

InChIKey=SGMZJAMFUVOLNK-UHFFFAOYSA-M

Molecular Weight:

139.624

Exact Mass:

139.076

EC Number:

200-655-4

UNII:

45I14D8O27

ICSC Number:

0853

NSC Number:

758473|402838

DSSTox ID:

DTXSID4020325

Color/Form:

WHITE CRYSTALS|Deliquescent crystals

HScode:

2923100000

Categories:

Vitamins and Minerals Medicines

Characteristics

PSA:

20.23

XLogP3:

log Kow = -5.16 (est)

Appearance:

White crystalline powder

Density:

1.205 g/cm3

Melting Point:

305 °C (decomp)

Water Solubility:

H2O: soluble

Storage Conditions:

0-6ºC

Toxicity:

LD50 in rats (g/kg): 0.400 i.p.; 6.64 orally (Hartung, Cornish)

PH:

4.7 (10% SOLN IN WATER)

Collision Cross Section:

121 Å² [M]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Aq soln is practically neutral

Air and Water Reactions:

Deliquescent. Very soluble in water. (NTP, 1992)

Reactive Group:

Alcohols and Polyols

Reactivity Profile:

Choline chloride is a quaternary ammonium salt. Quaternary ammonium salts often serve as catalysts in reactions. They are incompatible with many strong oxidizers and reducing agents, such as metal hydrides, alkali/active metals, and organometallics. Quaternary ammonium salts often serve as catalysts in reactions. They are incompatible with many strong oxidizers and reducing agents, such as metal hydrides, alkali/active metals, and organometallics. Unlike the ammonium ion, [NH4]+, and the primary, secondary, or tertiary ammonium cations, the quaternary ammonium cations are permanently charged, independent of the pH of their solution.

See More Choline chloride Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants.

See More Choline chloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

46 Inquiries

Country	Product	Purchase Quantity	Date Posted
Paraguay	Choline chloride	200 KG	Oct 27, 2025
Hongkong, China	Choline chloride	150 MT	Jul 21, 2023
Paraguay	Choline chloride	200.00 KG	Sep 25, 2025
United Arab Emirates	Choline Chloride	100 MT	May 26, 2026
Indonesia	choline chloride food grade 7.2 MT(combine into 1x20 FCL)	7.2 MT	Apr 13, 2026
United Kingdom	Choline chloride 97.6% White crystalline powderl	1000 KG	Mar 31, 2026
United States	choline chloride TGAI	2 KG	Jan 13, 2026
India	Choline Chloride	120 MT	Mar 12, 2025
Czech	Choline Chloride	179000 KG	Dec 16, 2024
Kazakstan	Choline chloride	20 TON	Nov 18, 2024
China	Cholinechloride 60% with ISO	150 MT	Oct 10, 2023
Philippines	Choline chloride	25.00 KG	Sep 16, 2023
India	best price feed grade choline chloride 60% corn cob powder for poultry and aquaculture	150 MT	Jul 27, 2023
Philippines	Choline Chloride 99% 0.3 1477 Choline Chloride	1 KG	Jun 27, 2023
United States	Choline chloride 99% powder	100 KG	Jun 11, 2023
Thailand	Choline chloride	23 MT	Apr 8, 2026
India	CHOLINE CHLORIDE 60%	2 20' Fcl	Jun 25, 2025
Malaysia	Choline Chloride	500 KG	Apr 9, 2025
United Arab Emirates	Choline Chloride	2 20' Fcl	Mar 31, 2025
Indonesia	Choline chloride	1 MT	Jan 16, 2025

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