Supply Reducing Agent CAS 25895-60-7 Sodium Cyanoborohydride Powder HuaMan

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• • Items	Specifications
    Product Name	Sodium Cyanoborohydride
    CAS No.	25895-60-7
    Appearance	white powder
    Assay	98%
    MF	CH3BNNa
    MW	62.84
    Melting Point	>242 °C (dec.) (lit.)
    Boiling Point	307°C
    Density	1.083 g/mL at 25 °C

    

    Certification 

    Technical Date Sheet:

    
    

    ITEM	SPECIFICATION	RESULT	METHOD
    Appearance	White powder, neutral odor, highly hygroscopic	Conforms	Visual
    Identification	Standard solution and test solution same spot,RF	Conforms	TLC
    Specific Optical	-2.4°~ -2.8°	-2.72°
    Heavy metals (as PB)	≤10ppm	Conforms	AAS
    Sulfate (SO4)	≤0.02%	Conforms	Colorimetry
    Chloride (Cl)	≤0.02%	Conforms	Colorimetry
    Phosphate Ion (P)	≤5ppm	Conforms	Colorimetry
    Residual solvent(ethanol)	≤1.0%	Conforms	HS-GC
    pH	4.5~7.0	5.10
    Related substance	Spot not bigger than standard solution spot	No spot	TLC
    Water Content	≤2%	0.26%	KF
    Assay (dried basis)	98.0%--102.0%	99.48%	Potentiometric titration
    Assay (dried basis)	98.5%--100%	99.2%	HPLC

    Sodium cyanoborohydride CAS 25895-60-7 is the chemical compound with the formula NaBH3CN. It is a colourless salt, but commercial samples can appear tan. It is widely used in organic synthesis for the reduction of imines. The salt tolerates aqueous conditions.

    Sodium cyanoborohydride CAS 25895-60-7 has molecular weight of 62.84. It is used in the synthesis of a novel phenolate-bridged dilanthanum(III) complex of interest as a model for metalloproteins as well as for its importance in basic and applied chemistry.

    Sodium cyanoborohydride CAS 25895-60-7 could be supplied in commercial size with competitive price.

    Function

    Sodium cyanoborohydride is widely used in organic synthesis for the reduction of imines. It is a mild reducing agent that converts imines to amines. It can be used to exchange the oxygen for an amine group on the carbonyl carbon of aldehydes or ketones when reacted with chemical or a primary amine.

    
    Sodium cyanoborohydride is the chemical compound with the formula NaBH3CN. It is a colourless salt, but commercial samples can appear tan. It is widely used in organic synthesis for the reduction of imines. The salt tolerates aqueous conditions.

    
    

    Application:

    1. Reducing agent. Selectively reduce fatty ketones and aldehydes into hydrocarbons, reduce enylamine into amines,ketones into ethers, Mannich bases into methyl compounds. Used with formaldehyde to methylate an amine or hydrazine. Reduction of alkyl iodide and p-toluene sulfonate into hydrocarbons and sulfoxide into sulfide in HMPT. It is also used for reducing amination.
    2. Sodium cyanoborohydride is used as a mild selective reduction agent in modern organic synthesis. It can reduce imines, ammonium salts, oxime and oxime derivatives, hydrazone and enamine, and can reduce the oxidation of carbonyl group through sulfonic acid hydrazone; Can reduce aldehydes, ketones, polarized alkenes, alkyl halides, epoxides, allyl ester groups.

    
    
    Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor, although its specific mechanism of action in atopic dermatitis is not known. In the US, crisaborole is indicated for topical treatment of mild to moderate atopic dermatitis in people three months of age and older. In the EU, crisaborole is indicated for treatment of mild to moderate atopic dermatitis in people two years of age and older with ≤ 40% body surface area (BSA) affected.

    
    

    Introduction:

    Criborole (AN2728) is a non-steroidal phosphodiesterase 4 (PDE-4) inhibitor. It was first developed by Anacor Pharmaceuticals. In December of the same year, the US FDA approved Criborone (AN2728) ointment (2% or 5%) for the topical treatment of patients over 2 years old. Severe to moderate atopic dermatitis, marketed under the trade name Eucrisa. Product advantages: The biggest advantage of criborole is that it is a small-molecule non-hormonal drug, which can achieve a combination of therapeutic effect and comfort, and even has almost no side effects for some patients. It is the first topical dermatology drug to enter the list of urgently needed new drugs in clinical practice. It can be said that the launch of criborole has filled the treatment needs of Chinese children and adults with atopic dermatitis, breaking the current situation of no new products in the field of topical non-hormonal anti-inflammatory for more than 10 years, which is of epoch-making significance.

    Market outlook:

    Criborole was developed by Anacor, and Pfizer acquired Anacor at a high price. In December 2016, Criborole was approved by the US FDA, becoming the first new drug approved by the US FDA for the treatment of atopic dermatitis (AD) in the past 15 years. molecular entities. In July 2020, Criborone ointment was approved by Chemicalbook in China, becoming the first and only hormone-free PDE-4 inhibitor suitable for the treatment of mild to moderate atopic dermatitis in children and adults aged 2 years and above in China Topical prescription drugs. Criborone is a phosphodiesterase 4 (PDE4) inhibitor. PDE4 is an enzyme involved in controlling the activity of inflammatory cells. PDE4 participates in IL-4/5 in inflammatory cells by controlling the degradation of cyclic adenosine monophosphate. The production of inflammatory factors such as /10/13 and prostaglandin PGE2 plays a role by inhibiting the activity of PDE4 and improves the body's inflammatory response. Clinical studies have shown that 28-day treatment with criborole resulted in significant remission, complete or almost complete resolution of the rash compared with placebo in patients 2-79 years of age with mild to moderate atopic dermatitis. In 2017, the sales of criborole were US$67 million; in 2018, the global sales of criborole were US$147 million, with a growth rate of 119.40%, which brought new hope to many patients with atopic dermatitis.

    Use:

    AN2728 has shown potent activity in vivo and in vitro, and the anti-inflammatory properties of AN2728 are being investigated. Also used as pharmaceutical intermediates. Biologically active Crisaborole (AN2728) is a selective small molecule PDE4 inhibitor with broad-spectrum anti-inflammatory activity.

    
    

    
    

    
    

    
    
    
    
    
    
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