Sodium Benzoate CAS#532-32-1 FACTORY OF SODIUM BENZOATE 99%

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• Description

  Sodium benzoate is a broad-spectrum antimicrobial agent, but its antimicrobial effectiveness is dependent on the pH of the food. As the acidity of the medium increases, its bactericidal and bacteriostatic effects are enhanced, but in alkaline medium, the bactericidal and bacteriostatic effects are lost. The optimum pH value of its anticorrosion is 2.5~4.0.

  Item	Standard	Result
  Characteristics	White Powder	White Powder
  Identifications	Qualfied	Qualfied
  Acidity or alkalinity	0.2	<0.20
  Assay	99.0%~100.5%	99.50%
  Heavy metals(Pb)	0.00%	<0.001%
  Ionic chloride	0.02%	<0.02
  Total chlocine	0.03%	<0.03
  Loss on drying	2.00%	1.13%
  Clarity and colour of solution	Qualified	Qualified
  Conclusion:	The product above complies with the BP-98.

  
  
  

  Applications

  Sodium benzoate is generally used in carbonated drinks, soy sauce, sauces, preserves and fruit and vegetable drinks.
  It can be used together with para-hydroxybenzoic acid esters in soy sauce and beverages for synergy.
  Sodium benzoate is often used to preserve highly acidic fruits, jams, beverage syrups and other acidic foods. It can be used in combination with low-temperature sterilization and has a synergistic effect.

  
  

  Storage

  Store in dry conditions below 30º C, away from sunlight. After opening, it should be stored in a separate package.

  
  

  
  
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    Finasteride is also a specific inhibitor of 5α-reductase. It can reduce the content of dihydrotestosterone in scalp hair follicles and serum, restore the hair growth function of the already suppressed hair follicle papilla, promote hair growth and prevent further hair loss.

    
    

    
    Function of  Crisaborole

    Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor, although its specific mechanism of action in atopic dermatitis is not known. In the US, crisaborole is indicated for topical treatment of mild to moderate atopic dermatitis in people three months of age and older. In the EU, crisaborole is indicated for treatment of mild to moderate atopic dermatitis in people two years of age and older with ≤ 40% body surface area (BSA) affected.

    Application of  Crisaborole
    
    Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor, although its specific mechanism of action in atopic dermatitis is not known. In the US, crisaborole is indicated for topical treatment of mild to moderate atopic dermatitis in people three months of age and older. In the EU, crisaborole is indicated for treatment of mild to moderate atopic dermatitis in people two years of age and older with ≤ 40% body surface area (BSA) affected.

    
    

    Introduction:

    Criborole (AN2728) is a non-steroidal phosphodiesterase 4 (PDE-4) inhibitor. It was first developed by Anacor Pharmaceuticals. In December of the same year, the US FDA approved Criborone (AN2728) ointment (2% or 5%) for the topical treatment of patients over 2 years old. Severe to moderate atopic dermatitis, marketed under the trade name Eucrisa. Product advantages: The biggest advantage of criborole is that it is a small-molecule non-hormonal drug, which can achieve a combination of therapeutic effect and comfort, and even has almost no side effects for some patients. It is the first topical dermatology drug to enter the list of urgently needed new drugs in clinical practice. It can be said that the launch of criborole has filled the treatment needs of Chinese children and adults with atopic dermatitis, breaking the current situation of no new products in the field of topical non-hormonal anti-inflammatory for more than 10 years, which is of epoch-making significance.

    Market outlook:

    Criborole was developed by Anacor, and Pfizer acquired Anacor at a high price. In December 2016, Criborole was approved by the US FDA, becoming the first new drug approved by the US FDA for the treatment of atopic dermatitis (AD) in the past 15 years. molecular entities. In July 2020, Criborone ointment was approved by Chemicalbook in China, becoming the first and only hormone-free PDE-4 inhibitor suitable for the treatment of mild to moderate atopic dermatitis in children and adults aged 2 years and above in China Topical prescription drugs. Criborone is a phosphodiesterase 4 (PDE4) inhibitor. PDE4 is an enzyme involved in controlling the activity of inflammatory cells. PDE4 participates in IL-4/5 in inflammatory cells by controlling the degradation of cyclic adenosine monophosphate. The production of inflammatory factors such as /10/13 and prostaglandin PGE2 plays a role by inhibiting the activity of PDE4 and improves the body's inflammatory response. Clinical studies have shown that 28-day treatment with criborole resulted in significant remission, complete or almost complete resolution of the rash compared with placebo in patients 2-79 years of age with mild to moderate atopic dermatitis. In 2017, the sales of criborole were US$67 million; in 2018, the global sales of criborole were US$147 million, with a growth rate of 119.40%, which brought new hope to many patients with atopic dermatitis.

    Use:

    AN2728 has shown potent activity in vivo and in vitro, and the anti-inflammatory properties of AN2728 are being investigated. Also used as pharmaceutical intermediates. Biologically active Crisaborole (AN2728) is a selective small molecule PDE4 inhibitor with broad-spectrum anti-inflammatory activity.

    
    

    
    

    
    

    
    
    
    
    
    
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