sles 70% sodium laureth sulfate, Sodium Lauryl Ether Sulfate 70% White or light yellow viscous paste or liquid HC05 hm

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• Chinese name: Sodium Lauryl Ether Sulfate
  Other names: Sodium Laureth Sulfate (AES or SLES) / Sodium Polyoxyethylene Ether Alkyl Sulfate / Sodium Ethoxylated Alkyl Sulfate
  English name: Sodium Lauryl Ether Sulfate
  English abbreviation: SLES
  Molecular formula: CH3(CH2)nOSO3Na, n=11,13
  Molecular weight: 376.48
  CAS No.: 68585-34-2 /9004-82-4
  HS code: 34021100
  Executive standard: GB/T 13529-2003
  Project indicators 70%
  Appearance White gel-like paste at 25°C
  smell special smell
  Active matter, % 70±2
  Unsulfated matter,% 2.5 max.
  Sulfate, % 1.5 max.
  1,4-Dioxane, PPM 50 max.
  pH value (25℃, 1% active substance aqueous solution) 7.0～9.5
  Color, Hazen (5% active in water) 20 max.

  AES (Sodium Fatty Alcohol Ether Sulfate)

  Item	Standard	Result
  Characteristics	White Powder	White Powder
  Identifications	Qualfied	Qualfied
  Acidity or alkalinity	0.2	<0.20
  Assay	99.0%~100.5%	99.50%
  Heavy metals(Pb)	0.00%	<0.001%
  Ionic chloride	0.02%	<0.02
  Total chlocine	0.03%	<0.03
  Loss on drying	2.00%	1.13%
  Clarity and colour of solution	Qualified	Qualified
  Conclusion:	The product above complies with the BP-98.

  
  
  

  Storage: At high temperature (above 50 degrees Celsius) or in an acidic (pH5) environment, alkyl ether sulfate may decompose. The reason for the decomposition is the hydrolysis of alkyl ether sulfate. In view of the fact that alkyl ether sulfate is easily hydrolyzed at high temperature, this product should not be stored in an environment above 50 degrees Celsius.

  
  

  
  

  
  

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    Finasteride is also a specific inhibitor of 5α-reductase. It can reduce the content of dihydrotestosterone in scalp hair follicles and serum, restore the hair growth function of the already suppressed hair follicle papilla, promote hair growth and prevent further hair loss.

    
    

    
    Function of  Crisaborole

    Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor, although its specific mechanism of action in atopic dermatitis is not known. In the US, crisaborole is indicated for topical treatment of mild to moderate atopic dermatitis in people three months of age and older. In the EU, crisaborole is indicated for treatment of mild to moderate atopic dermatitis in people two years of age and older with ≤ 40% body surface area (BSA) affected.

    Application of  Crisaborole
    
    Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor, although its specific mechanism of action in atopic dermatitis is not known. In the US, crisaborole is indicated for topical treatment of mild to moderate atopic dermatitis in people three months of age and older. In the EU, crisaborole is indicated for treatment of mild to moderate atopic dermatitis in people two years of age and older with ≤ 40% body surface area (BSA) affected.

    
    

    Introduction:

    Criborole (AN2728) is a non-steroidal phosphodiesterase 4 (PDE-4) inhibitor. It was first developed by Anacor Pharmaceuticals. In December of the same year, the US FDA approved Criborone (AN2728) ointment (2% or 5%) for the topical treatment of patients over 2 years old. Severe to moderate atopic dermatitis, marketed under the trade name Eucrisa. Product advantages: The biggest advantage of criborole is that it is a small-molecule non-hormonal drug, which can achieve a combination of therapeutic effect and comfort, and even has almost no side effects for some patients. It is the first topical dermatology drug to enter the list of urgently needed new drugs in clinical practice. It can be said that the launch of criborole has filled the treatment needs of Chinese children and adults with atopic dermatitis, breaking the current situation of no new products in the field of topical non-hormonal anti-inflammatory for more than 10 years, which is of epoch-making significance.

    Market outlook:

    Criborole was developed by Anacor, and Pfizer acquired Anacor at a high price. In December 2016, Criborole was approved by the US FDA, becoming the first new drug approved by the US FDA for the treatment of atopic dermatitis (AD) in the past 15 years. molecular entities. In July 2020, Criborone ointment was approved by Chemicalbook in China, becoming the first and only hormone-free PDE-4 inhibitor suitable for the treatment of mild to moderate atopic dermatitis in children and adults aged 2 years and above in China Topical prescription drugs. Criborone is a phosphodiesterase 4 (PDE4) inhibitor. PDE4 is an enzyme involved in controlling the activity of inflammatory cells. PDE4 participates in IL-4/5 in inflammatory cells by controlling the degradation of cyclic adenosine monophosphate. The production of inflammatory factors such as /10/13 and prostaglandin PGE2 plays a role by inhibiting the activity of PDE4 and improves the body's inflammatory response. Clinical studies have shown that 28-day treatment with criborole resulted in significant remission, complete or almost complete resolution of the rash compared with placebo in patients 2-79 years of age with mild to moderate atopic dermatitis. In 2017, the sales of criborole were US$67 million; in 2018, the global sales of criborole were US$147 million, with a growth rate of 119.40%, which brought new hope to many patients with atopic dermatitis.

    Use:

    AN2728 has shown potent activity in vivo and in vitro, and the anti-inflammatory properties of AN2728 are being investigated. Also used as pharmaceutical intermediates. Biologically active Crisaborole (AN2728) is a selective small molecule PDE4 inhibitor with broad-spectrum anti-inflammatory activity.

    
    

    
    

    
    

    
    
    
    
    
    
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