API Loratadine

Name	Loratadine
CAS number	79794-75-5
Synonym	Loratadine; Claritin; Loratidine; Clarityn; Alavert; Loratadine Wyeth Brand; Sch 29851; Sch-29851; Sch29851; Wyeth Brand of Loratadine
Description	Loratadine is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines it lacks central nervous system depressing effects such as drowsiness. It has been shown to inhibit the release of leukotriene C4 and histamine from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs. Loratadine is a selective inverse peripheral histamine H1-receptor agonist.
Structure
Molecular Formula	C22H23ClN2O2
Molecular Weight	382.888
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Loratadine More Info

1. Drug Name

Loratadine is a second - generation anti - histamine drug and a long - acting tricyclic anti - histamine.

2. Pharmacological Action

(1) Mechanism of Action

Loratadine can selectively act on the peripheral H1 - receptors for a long time. It competitively inhibits the binding of histamine to H1 - receptors, thus reducing various allergic reaction symptoms caused by histamine. Histamine is a key mediator in allergic and inflammatory reactions. When the body is exposed to allergens, mast cells and basophils release histamine. After histamine binds to H1 - receptors, it leads to a series of reactions such as vasodilation, increased capillary permeability and smooth muscle contraction, causing itching, redness, sneezing, runny nose and other allergic symptoms. Loratadine alleviates allergic reactions by blocking this process.

(2) Efficacy Characteristics

It has the characteristics of quick onset. Generally, it can take effect 1 - 3 hours after oral administration. Moreover, its efficacy lasts for a long time, about 24 hours, which enables patients usually to take the drug only once a day to effectively control the symptoms.

3. Indications

(1) Allergic Rhinitis

It is used to relieve symptoms related to allergic rhinitis, such as sneezing, runny nose, nasal itching, nasal congestion and itchy and burning sensations in the eyes. For example, during the pollen season, many people will have allergic rhinitis symptoms due to inhaling pollen, and loratadine can effectively relieve these symptoms and make patients feel more comfortable.

(2) Chronic Urticaria

It also has good curative effects on chronic urticaria, pruritic skin diseases and other allergic skin diseases. For example, when patients have skin itching and wheals (typical symptoms of urticaria), taking loratadine can reduce the itching sensation and relieve the frequency and severity of wheal attacks.

4. Dosage Forms and Usage

(1) Dosage Forms

Loratadine has a variety of dosage forms, including tablets, capsules and syrups. Tablets and capsules are convenient for adults to take, while syrups are mainly used for people such as children who have difficulty swallowing tablets or capsules.

(2) Usage and Dosage

For adults and children over 12 years old, take loratadine tablets or capsules orally, generally once a day, 10mg each time. If using loratadine syrup, the dosage needs to be adjusted according to factors such as the patient's age and weight. For example, for children aged 2 - 12 years old, those with a body weight over 30kg take 10ml once a day; those with a body weight less than or equal to 30kg take 5ml once a day.

5. Adverse Reactions and Precautions

(1) Adverse Reactions

The adverse reactions of loratadine are relatively mild. Common ones include fatigue, headache, drowsiness and dry mouth. These adverse reactions are usually temporary and may gradually subside during the continuous drug - taking process. For example, some patients may feel a dry mouth after just starting to take loratadine. This is because the drug has a certain inhibitory effect on the secretion of salivary glands. But as the body adapts to the drug, the dry - mouth symptom may be alleviated.

(2) Precautions

Patients with severe liver insufficiency should use it under the guidance of a doctor, because the liver is an important organ for drug metabolism and liver insufficiency may affect the metabolic process of loratadine. At the same time, during the period of taking loratadine, activities that require high - concentration attention such as driving vehicles and operating machines should be avoided, especially just after taking the drug, because the drug may cause drowsiness and other adverse reactions and increase the risk of accidents.