Loratadine 99% powder Dideu
1 Inquiries
79794-75-5
Pharmaceutical Grade
99%
Ang port in China
Dideu
25Kg/Drum
2023-01-01
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceLoratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.IC50 value: 32 uMTarget: H1-receptorLoratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells.
Solid
Loratadine is a benzocycloheptapyridine. It has a role as a geroprotector.|Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.|Loratadine and its metabolic derivative desloratadine are second generation antihistamines that are used for the treatment of allergic rhinitis, angioedema and chronic urticaria. Loratadine and desloratadine have been linked to rare, isolated instances of clinically apparent acute liver injury.|Loratadine is a piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects. Loratadine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects.|A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.Basic Info-
Product Name:
Loratadine
Other Name:1-Piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-,ethyl ester;11H-Benzo[5,6]cyclohepta[1,2-b]pyridine,1-piperidinecarboxylic acid deriv.;Sch 29851;Loratadine;Loratidine;Klaritin;Claritin;Bonalerg;Civeran;Anhissen;Claritine;Clarityn;Claratyne;Cronopen;Fristamin;Histaloran;Lertamine;Lisino;Loracert;Clarityne;Loranox;Lorastine;Loratyne;Lorfast;Lowadina;Optimin;Polaratyne;Pylor;Restamine;Sensibit;Sohotin;Tadine;Velodan;Zeos;Loradex;Alavert;Flonidan;Klarifer;Clarotadin;Erolin;Lomilan;Symphoral
CAS No.:79794-75-5
Molecular Formula:C22H23ClN2O2
InChIKeys:InChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N
Molecular Weight:382.88
Exact Mass:382.88
EC Number:1308068-626-2
UNII:7AJO3BO7QN
NSC Number:758628|721075
DSSTox ID:DTXSID2023224
NCI Thesaurus Code:C29162
Color/Form:Crystals from acetonitrile
ATC Code:R06AX13|R - Respiratory system
HScode:2933990090
Categories:
Characteristics-
PSA:
42.4
XLogP3:5.2
Appearance:white powder
Density:1.3±0.1 g/cm3
Melting Point:134-136 °C
Boiling Point:531.3°C at 760 mmHg
Flash Point:275.1±30.1 °C
Refractive Index:1.614
Water Solubility:It is soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25°C), water (<1 mg/ml at 25°C), chloroform, and methanol.
Storage Conditions:2-8°C
Collision Cross Section:187.4 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|185.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Skin sensitization, Category 1
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H341 Suspected of causing genetic defects
H351 Suspected of causing cancer
H400 Very toxic to aquatic life
H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P273 Avoid release to the environment.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P333+P317 If skin irritation or rash occurs: Get medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
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Certifications:
ISO Certificate,REACH
">Company Profile -
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted
Pakistan
Loratadine
20 KG May 16, 2025 Post an enquiry for this product














