USA/EU/AU Warehouse Supply High Quality Estradiol valerate CAS 979-32-8 Best Price in Estradiolvalerate/delestrogen HM
TDS 5 Inquiries
979-32-8
Industrial Grade
99%
tianjin
HuaMan
10 bottles/box
2025-01-03
Propylene glycol
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceEstradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.
Estradiol valerate is a steroid ester.|Estradiol Valerate (also known as E2V) is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located in various tissues including in the breasts, uterus, ovaries, skin, prostate, bone, fat, and brain. [DB00783] is commonly produced with an ester side-chain as endogenous estradiol has very low oral bioavailability on its own (2-10%). First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a chance to enter systemic circulation and exert its estrogenic effects. Esterification of estradiol aims to improves absorption and bioavailability after oral administration (such as with Estradiol valerate) or to sustain release from depot intramuscular injections (such as with Estradiol Cypionate) through improved lipophilicity. Following absorption, the esters are cleaved, resulting in the release of endogenous estradiol, or 17β-estradiol. Ester pro-drugs of estradiol are therefore considered to be bioidentical forms of estrogen. Estradiol valerate is commercially available as an intramuscular injection as the product Delestrogen and is indicated for the treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). Estradiol valerate is also available in combination with [DB09123] as the commercially available product Natazia used for the prevention of pregnancy and for the treatment of heavy menstrual bleeding. The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. However, after menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol at the receptor level. Because of the difference in potency between estradiol and estrone, menopause (and a change in primary hormone from estradiol to estrone) is associated with a number of symptoms associated with this reduction in potency and in estrogenic effects. These include hot flashes, vaginal dryness, mood changes, irregular menses, chills, and sleeping problems. Administration of synthetic and bioidentical forms of estrogen, such as estradiol valerate, has shown to improve these menopausal symptoms.|Estradiol Valerate is the parenterally-administered synthetic valerate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04)|The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Certificates-
TDS
Basic Info-
Product Name:
Estradiol valerate
Other Name:Estra-1,3,5(10)-triene-3,17-diol (17β)-,17-pentanoate;Estradiol,17-valerate;Estradiol valerate;Delahormone unimatic;Delestrogen 4x;Estra-1,3,5(10)-triene-3,17β-diol 17-valerate;Estradiol 17β-valerate;Estradiol valerianate;Progynon-Depot;3-Hydroxy-17β-valeroyloxyestra-1,3,5(10)-triene;Atladiol;Deladiol;Progynova;Estraval;Femogex;Neofollin;Pharlon;Dura-Estradiol;Delestrogen;Primogyn-Depot;Nuvelle;Oestradiol valerinate;Pelanin Depot;Gynogen LA;Gynogen LA 40;NSC 17590;Valergen;Climaval;Primofol-Depot;Gynokadin;Meriestra;Valest;907-12-0;69557-95-5
CAS No.:979-32-8
Molecular Formula:C23H32O3
InChIKeys:InChIKey=RSEPBGGWRJCQGY-RBRWEJTLSA-N
Molecular Weight:356.5
Exact Mass:356.50
EC Number:213-559-2
UNII:OKG364O896
NSC Number:17590
DSSTox ID:DTXSID8023004
NCI Thesaurus Code:C1090
HScode:29372390
Categories:
Characteristics-
PSA:
46.5
XLogP3:5.35030
Appearance:Na
Density:1.1±0.1 g/cm3
Melting Point:144-145 °C
Boiling Point:486.2°C at 760 mmHg
Flash Point:191.1±21.5 °C
Refractive Index:1.568
Collision Cross Section:171 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Propylene glycol
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Location:
No .41 Optics Valley Avenue, East Lake High-tech Development Zone, Wuhan ,China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment
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Average lead Time:
5
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
11-50
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Year of Establishment:
2024
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Inquiry History5 Inquiries
Country Product Purchase Quantity Date Posted 
Norway
β-Estradiol 17-valerate 98% Powder 979-32-8 Estradiol Valerate
10 G Apr 15, 2025 
United States
Factory supply β-Estradiol 17-valerate 98% Powder 979-32-8 Estradiol Valerate raw powder
1 KG Jul 20, 2024 
Germany
Estradiol Valerate
5 G Mar 15, 2026
United States
Estradiol valerate 99% Dideu-5-00472 Dideu
25 KG Nov 15, 2024 
New Zealand
Estradoil Valerate 99%powder
3 KG Jan 11, 2024 Post an enquiry for this product
