Estradiol Enanthate cas 4956-37-0 good price

MF C25H28O3
MW 376.5
EINECS NO. 200-043-7
Melting Point 191-198 °C(lit.)
Boiling Point 465.03°C (rough estimate)
Density 1.0493 (rough estimate)
Storage 2-8°C

Description Estradiolbenzoate is a synthetic ester, especially 3-benzoyl ester, natural estrogen, estradiol. Estrogens guides the development of female genes during embryonic development and puberty. Estradiol is the main female hormone secreted by the ovaries before menopause. Estradiolbenzoat Chemicalbooke is an estradiol analogue that contains a benzyl ester at the C-3 position and is often used in combination with progesterone to induce estrus in livestock. The compound binds to human and mouse estrogen receptor alpha (ERα), and chicken ER, with IC50 values ranging from 22-28 nM.

This reflects a 6-10 fold reduction in affinity compared to estradiol.
Application The effects of daily injections of 5 microgram estradiol benzoate (EB) on the patterns of food and ethano consumption were studied in ovarectomized rats given free access to food, a 10% ethano solution, and water. EB led to an immediate, but transient, suppression of both food and ethano intake. The time course and magnitude of these effects were virtually identical. While the decrease in total food intake was achieved by a permanent decrease in the duration of eating bouts, the decline in total ethano consumption apparently resulted from decreased rates of licking within bouts.

Gradual increases in the frequency of eating and ethano-drinking bouts allowed total food and ethano intake to return to baseline within three weeks of the first injection. Total water intake rose three-fold during EB administration and this was due to increases in both the duration and frequency of drinking bouts. The similarity in effects induced by EB on the patterns of food and ethano intake were discussed in terms of ethano's caloric property.