Erdosteine API
GMP
84611-23-4
中国
25kg/drum
Yes
2024-12-31
Aspirin,Salicylic Acid
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceErdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation.
Erdosteine is a N-acyl-amino acid.|Erdosteine is a drug that causes a breakdown of mucus, also known as a mucolytic agent. It is a thiol derivative produced for the clinical management of chronic obstructive bronchitis, in addition to infective exacerbations of chronic bronchitis. This drug contains sulfhydryl groups which are released after erdosteine undergoes hepatic first pass metabolism. Three active metabolites result and possess mucolytic activity in addition to free radical scavenging activity. Erdosteine acts to control mucus production and control its viscosity while increasing mucociliary transport. It also combats the effects of free radicals resulting from cigarette smoke. Erdosteine has been shown to be safe and well tolerated in clinical trials. Erdosteine 300mg twice daily reduced cough (both frequency and severity) and sputum viscosity more quickly and more effectively than placebo and reduced the adhesivity of sputum more effectively than ambroxol 30mg twice daily. Co-administration of erdosteine and amoxicillin in patients with acute infective exacerbation of chronic bronchitis resulted in higher concentrations of the antibiotic in the sputum, leading to earlier and more pronounced amelioration of clinical symptoms compared with placebo. Erdosteine is associated with a low incidence of adverse events, most of which are gastrointestinal and generally mild.CertificatesBasic Info-
Product Name:
Erdosteine
Other Name:Acetic acid,2-[[2-oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]-;Acetic acid,[[2-oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]-;2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetic acid;Erdosteine;RV 144;Dithiosteine;Secresolv;Erdostin;Mucotec;2-[2-Oxo-2-[(2-oxothiolan-3-yl)amino]ethyl]sulfanylacetic acid;2-([[(2-Oxothiolan-3-yl)carbamoyl]methyl]sulfanyl)acetic acid;105426-14-0
CAS No.:84611-23-4
Molecular Formula:C8H11NO4S2
InChIKeys:InChIKey=QGFORSXNKQLDNO-UHFFFAOYSA-N
Molecular Weight:249.31
Exact Mass:249.31
EC Number:1312995-182-4
DSSTox ID:DTXSID8048735
ATC Code:R05CB15|R - Respiratory system
HScode:2934999090
Categories:
Characteristics-
PSA:
134
XLogP3:-0.1
Density:1.5±0.1 g/cm3
Melting Point:156-158 °C
Boiling Point:590.4°C at 760 mmHg
Flash Point:310.8±30.1 °C
Refractive Index:1.615
Storage Conditions:Refrigerator
Toxicity:LD50 in mice and rats (g/kg): >10 orally; >3.5 i.v. (Gonella)
Hazard IdentificationClassification of the substance or mixture
Eye irritation, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H319 Causes serious eye irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Aspirin,Salicylic Acid
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Location:
No. 0006, Donghua street, North New District, hi tech Zone, Hengshui, Hebei Province
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A
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Average lead Time:
60 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
201-300
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Year of Establishment:
2019
Hebei Jingye Pharmaceutical Technology Co., Ltd. is a pharmaceutical high-tech enterprise based in China and facing the world. The company is committed to growing into a manufacturer of high-quality salicylic acid and aspirin, focusing on the manufacture, development and service of cardio-cerebrovascular preparations and APIs . There are 4 existing product varieties and 6 reserve varieties, all of which have broad development prospects in the field of cardiovascular and cerebrovascular preparations and APIs.
Hebei Jingye Pharmaceutical Technology Co., Ltd.
Jingye Group is a large-scale group company with steel as its main business and concurrently engaged in deep processing of steel, international trade, powder metallurgy 3D printing, tourism and hotels. It has 23,500 employees and total assets of 39 billion yuan. In 2018, the Group achieved sales revenue of RMB 90.1 billion and tax revenue of RMB 3.35 billion. The Dedicated Group ranks 217 among the top 500 enterprises in the country, and 95 among the top 500 Chinese manufacturing enterprises. The group is a large-scale rebar production base in the world. It was selected as the first batch of green factories in 2017 by the Ministry of Industry and Information Technology, and was rated as the "2017 Beijing-Tianjin-Hebei Most Influential Responsible Brand. The "dedication" trademark is a well-known trademark in China, with a dedicated brand value of 20.668 billion yuan.
The company was founded in 1989 with advanced technological equipment and strong technical force. The main products are the dedicated brand sublimation salicylic acid, medicinal salicylic acid, and aspirin. The company has self-support import and export rights, and its products are sold at home and abroad, and its foreign exports are all over the United States, Russia, Britain, Germany, France and other European and American countries and a large number of Asian countries and regions.
In order to make the pharmaceutical industry bigger and stronger, the new plant is located in the National Technology Development Zone-Beijing·Cangzhou Bohai New Area Biomedical Industrial Park. The new plant covers an area of 100 acres and was heavily built by Tianjin Medical Design Institute with a total investment of 350 million yuan.
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