High Quality Veterinary Raw Powder Flubendazole CAS 31430-15-6 with EP Standard

Flubendazole More Info

Flubendazole is a benzimidazole carbamate anthelmintic agent primarily used to treat parasitic infections, particularly those caused by gastrointestinal nematodes. Initially developed in the 1970s, it has gained attention for its potential anticancer properties, demonstrating efficacy against various cancer types.

Mechanism of Action

Flubendazole exerts its effects through several mechanisms:
Tubulin Binding: It binds to the polymerization site of tubulin, disrupting microtubule dynamics. This inhibition prevents the formation and stability of microtubules, which are essential for cell division and function in both parasites and cancer cells.
Cell Cycle Arrest: By inhibiting tubulin polymerization, flubendazole induces G2/M phase cell cycle arrest, preventing cancer cells from progressing through the cell cycle and leading to mitotic catastrophe.
Induction of Apoptosis and Autophagy: The drug promotes programmed cell death (apoptosis) and autophagic processes, which are critical for removing damaged cells and maintaining cellular homeostasis.
Inhibition of Angiogenesis: Flubendazole has been shown to inhibit the formation of new blood vessels (angiogenesis), which is vital for tumor growth and metastasis.

Applications

Flubendazole is primarily indicated for:
Anthelmintic Use: Effective against a variety of helminths, including roundworms and hookworms.
Anticancer Research: Emerging studies suggest its potential as an anticancer agent in treating various cancers such as melanoma, glioblastoma, and hepatocellular carcinoma due to its ability to inhibit tumor growth and induce cell death.

Routes of Administration

Flubendazole is typically administered orally in tablet form. It may also be available in other formulations depending on the specific treatment context.

Safety and Side Effects

Common Side Effects
Flubendazole is generally well-tolerated, but some side effects may occur:
Gastrointestinal disturbances (nausea, diarrhea)
Headaches
Dizziness
Serious Side Effects
While serious side effects are rare, they may include:
Allergic reactions (hives, swelling)
Liver function abnormalities (elevated liver enzymes)
Potential for severe skin reactions (though not commonly reported)

Pharmacokinetics

Absorption and Distribution
Flubendazole is well absorbed from the gastrointestinal tract. Its pharmacokinetics can be influenced by factors such as food intake and individual metabolism.
Metabolism
The drug undergoes hepatic metabolism, primarily through glucuronidation. Its metabolites are excreted mainly via urine.
Elimination
The elimination half-life of flubendazole varies but generally supports once or twice daily dosing for effective therapeutic levels.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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Suitable for more than 50kg 
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Suitable for more than 500kg      
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We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
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2. Packaging photo
3. COA, MSDS, etc
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5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.