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High Quality Velpatasvir CAS 1377049-84-7 Powder Fast Shipping Good Price

Name: High Quality Velpatasvir CAS 1377049-84-7 Powder Fast Shipping Good Price
Brand: HyperChem
SKU: pr2501081063
Price: 130 USD
Availability: InStock

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CAS No.:

1377049-84-7

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/Bag

Price valid (until):

2025-02-08

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
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Inquiry History

Description

Name	Velpatasvir
CAS number	1377049-84-7
Synonym	AZD-6140; AZD6140; AZD 6140; AR-C 126532XX; AR-C-126532XX
Description	Velpatasvir, also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. GS-5816 has demonstrated pan-genotypic activity and a high barrier to resistance in HCV replicon assays. GS-5816 demonstrated pangenotypic antiviral activity in patients with genotype 1-4 HCV infection.
Structure
Molecular Formula	C49H54N8O8
Molecular Weight	883 g/mol
Appearance	White Powder
Quality Standard	99%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 2~8 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag, Bottle
Commercial package	Aluminium Tin
Origin	China

Velpatasvir More Info

Velpatasvir is an antiviral medication used in the treatment of chronic hepatitis C virus (HCV) infection. It is a direct-acting antiviral (DAA) that inhibits the HCV NS5A protein, which is essential for the viral replication process. Velpatasvir is often utilized in combination with other antiviral agents to enhance treatment efficacy and improve patient outcomes.

Mechanism of Action

Velpatasvir targets and inhibits the NS5A protein, a multifunctional protein critical for viral RNA replication and assembly. By blocking NS5A, velpatasvir disrupts the lifecycle of the hepatitis C virus, thereby preventing its ability to replicate and spread within the host.

Indications

Velpatasvir is indicated for the treatment of chronic HCV infection in adults and may be used in combination with other antiviral agents, such as:

Sofosbuvir: This combination has shown high efficacy against various HCV genotypes.

Other direct-acting antivirals, depending on the specific treatment regimen recommended by healthcare providers.

Dosage and Administration

Velpatasvir is administered orally, usually in the form of a fixed-dose combination tablet. The typical dosage and duration of treatment vary based on factors such as:

The specific genotype of HCV.

The presence of liver cirrhosis.

Prior treatment history.

Treatment regimens often last between 8 to 12 weeks, but this may be adjusted based on individual patient responses and clinical assessments.

Side Effects

Common side effects associated with velpatasvir may include:

Fatigue

Headache

Nausea

Diarrhea

Most side effects are generally mild and manageable. However, patients should be monitored for any adverse reactions, especially during the initial phase of treatment.

Drug Interactions

Velpatasvir can interact with other medications, particularly those that influence liver enzymes (specifically, CYP450). Healthcare providers need to be aware of potential interactions to adjust dosage or monitor for adverse effects accordingly.

Safety and Precautions

Velpatasvir is generally well-tolerated, but certain precautions are necessary, such as:

Assessing liver function before treatment, especially in patients with existing liver conditions.

Monitoring patients for signs of hepatic decompensation, particularly in those with cirrhosis.

Consideration of potential hypersensitivity reactions, although these are rare.

Regulatory Status

Velpatasvir is approved by health authorities in many regions for the treatment of chronic hepatitis C. Regulations regarding its use may vary, and healthcare providers should remain updated on local guidelines and recommendations.

Conclusion

Velpatasvir is an important component of the modern therapeutic arsenal against chronic hepatitis C virus infection. Its mechanism of action as an NS5A inhibitor makes it effective in promoting viral clearance when used in combination with other direct-acting antivirals. Careful management of dosage, monitoring for side effects, and awareness of drug interactions are crucial for optimizing treatment efficacy and ensuring patient safety.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders:
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

ECHEMI Editorial Reference

ChEBI: A complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes.
Velpatasvir is a complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes. It has a role as an antiviral drug and a hepatitis C virus nonstructural protein 5A inhibitor. It is an organic heteropentacyclic compound, a N-acylpyrrolidine, a L-valine derivative, a carbamate ester, a member of imidazoles, a ring assembly and an ether.|Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients. Velpatasvir acts as a defective substrate for NS5A (Non-Structural Protein 5A), a non-enzymatic viral protein that plays a key role in Hepatitis C Virus replication, assembly, and modulation of host immune responses. Treatment options for chronic Hepatitis C have advanced significantly since 2011, with the development of Direct Acting Antivirals (DAAs) such as velpatasvir. Notably, velpatasvir has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102], making it a highly potent and reliable alternative for treatment of chronic Hepatitis C. In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) recommend Velpatasvir as first line therapy in combination with sofosbuvir for all six genotypes of Hepatitis C. Velpatasvir is currently only available within a fixed dose combination product as Epclusa with [DB08934], another direct acting antiviral. Goals of therapy for Epclusa include the intent to cure, or achieve a sustained virologic response (SVR), after 12 weeks of daily therapy. SVR and eradication of HCV infection is associated with significant long-term health benefits including reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma, and reduced all-cause mortality and risk of requiring a liver transplant. Since June 2016, Velpatasvir has been available as a fixed dose combination product with [DB08934], as the commercially available product Epclusa. Epclusa is the first combination HCV product indicated for the treatment of all genotypes of Hepatitis C with or without cirrhosis. It is also currently the most potent HCV antiviral medication on the market with a sustained virologic response (SVR) after 12 weeks of therapy of 93-99% depending on genotype and level of cirrhosis and a high barrier to resistance. Both Canadian and American guidelines list Epclusa as a first line recommendation for all genotypes of HCV.|Velpatasvir is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of velpatasvir is as a Breast Cancer Resistance Protein Inhibitor, and P-Glycoprotein Inhibitor, and Organic Anion Transporting Polypeptide 1B1 Inhibitor, and Organic Anion Transporting Polypeptide 1B3 Inhibitor, and Organic Anion Transporting Polypeptide 2B1 Inhibitor.|Velpatasvir is an orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV genotypes 1-6. Although the exact mechanism of action of velpatasvir has not yet been completely determined, upon oral administration and intracellular uptake, it appears to bind to domain I of the NS5A protein. This inhibits the activity of the NS5A protein and results in the disruption of the viral RNA replication complex, blockage of viral HCV RNA production, and inhibition of viral replication. NS5A, a zinc-binding and proline-rich hydrophilic phosphoprotein, plays a crucial role in HCV RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.

Certificates

Basic Info

Product Name:

Velpatasvir

Other Name:

Carbamic acid,N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4′,3′:6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-,methyl ester;Velpatasvir;GS 5816;Methyl [(2S)-1-[(2S,5S)-2-[9-[2-[(2S,4S)-1-[(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl]-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate;1458063-71-2

CAS No.:

1377049-84-7

Molecular Formula:

C49H54N8O8

InChIKeys:

InChIKey=FHCUMDQMBHQXKK-CDIODLITSA-N

Molecular Weight:

883.019

Exact Mass:

883.00

UNII:

KCU0C7RS7Z

NCI Thesaurus Code:

C152851

ATC Code:

J05A

Categories:

Other Chemical Drugs

Characteristics

PSA:

193

XLogP3:

6.2

Density:

1.314±0.06 g/cm3(Predicted)

See More Velpatasvir Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Velpatasvir Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

10 Inquiries

Country	Product	Purchase Quantity	Date Posted
Russia	Velpatasvir	17.00 G	Aug 14, 2024
Russia	PRL-8-53	10.00 G	Aug 14, 2024
Russia	Sofosbuvir	68.00 G	Aug 14, 2024
Russia	Enclomiphene	100.00 G	Aug 14, 2024
Russia	7,8-Dihydroxyflavone	75.00 G	Aug 14, 2024
Russia	Citicoline sodium	750.00 G	Aug 14, 2024
Russia	NNMTi	15.00 G	Aug 14, 2024
Russia	Unifiram	30.00 G	Aug 14, 2024
Russia	Coluracetam	100.00 G	Aug 14, 2024
Russia	DIHEXA	50.00 G	Aug 14, 2024

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High Quality Velpatasvir CAS 1377049-84-7 Powder Fast Shipping Good Price

Product Description

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