Name | Epitalon |
CAS number | 307297-39-8 |
EINECS number | 211-519-9 |
Related CAS# | 307297-40-1 (acetate); 307297-39-8 (free base) |
Synonym | Epitalon; Epithalon; Glycine,L-alanyl-L-a-glutamyl-L-a-aspartyl-;L-alanyl-L-alpha-glutamyl-L-alpha-aspartylglycine; L-Alanyl-L-α-glutamyl-L-α aspartylglycine; Epithalon Acetate; Epithalon; Epithalamin |
Description | Epitalon is a synthetic tetrapeptide derived from the natural peptide Epithalamin, which is produced by the pineal gland. It consists of four amino acids: Alanine (Ala), Glutamic acid (Glu), Aspartic acid (Asp), and Glycine (Gly), forming the sequence Ala-Glu-Asp-Gly. Epitalon has been extensively studied for its potential anti-aging properties and has shown promise in various research fields. Its primary function is to stimulate telomerase activity, an enzyme crucial for maintaining telomere length, which helps protect DNA integrity and delays cellular aging. Additionally, Epitalon has been shown to regulate melatonin production, which plays a significant role in sleep-wake cycles and overall health. |
Structure |  |
Molecular Formula | C14H22N4O9 |
Molecular Weight | 390.35 g/mol |
Appearance | Solid powder |
Quality Standard | EP/BP Standard |
Assay | ≥98% |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition | Store in cool place. Keep container tightly closed in a dry and well ventilated place. |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
HS Code | 2934999099 |
Epitalon is a synthetic tetrapeptide composed of the amino acids alanine, glutamic acid, aspartic acid, and glycine (Ala-Glu-Asp-Gly). It has gained attention for its potential anti-aging properties and is primarily studied for its ability to stimulate the enzyme telomerase, which plays a crucial role in maintaining telomere length. Telomeres are protective caps at the ends of chromosomes that shorten with each cell division, and their length is associated with cellular aging.
Mechanism of Action
Epitalon functions through several key mechanisms:
Telomerase Activation: By stimulating telomerase activity, Epitalon can potentially elongate telomeres, thereby delaying cellular aging and promoting cellular regeneration. This action may help extend the lifespan of cells and improve their function.
Regulation of Melatonin Production: Epitalon is believed to influence the pineal gland's activity, leading to increased production of melatonin. Melatonin is important for regulating sleep-wake cycles and has antioxidant properties that can protect against oxidative stress.
Immunomodulatory Effects: Epitalon may enhance immune function by modulating cytokine production and promoting a balanced immune response.
Applications
Epitalon has been investigated for various potential applications, including:
Anti-Aging Treatments: Due to its effects on telomere maintenance and cellular regeneration.
Metabolic Health: Research suggests it may improve metabolic parameters and promote better glucose metabolism.
Sleep Regulation: Its influence on melatonin levels may help improve sleep quality.
Cancer Research: Some studies indicate potential anti-tumor effects, though more research is needed in this area.
Routes of Administration
Epitalon is typically administered via:
Subcutaneous or Intramuscular Injection: Commonly used in clinical or research settings. Dosing regimens often involve cycles of treatment followed by breaks.
Safety and Side Effects
Common Side Effects
Epitalon is generally considered safe with minimal reported side effects. Commonly noted reactions include:
Minor injection site reactions (e.g., redness or swelling)
Mild gastrointestinal discomfort
Serious Side Effects
Serious adverse effects are not well-documented due to limited human clinical trials. However, potential risks could include:
Allergic reactions
Unknown long-term effects due to insufficient comprehensive studies
Precautions
As with any peptide therapy, caution should be exercised regarding the source and quality of Epitalon used, as impurities or improper formulations can pose risks.
Pharmacokinetics
Absorption and Distribution
Epitalon is rapidly absorbed following injection, but specific pharmacokinetic data regarding its distribution and metabolism in humans are limited.
Metabolism and Excretion
The peptide is likely metabolized by proteolytic enzymes in the body, but detailed studies on its metabolic pathways are still needed.
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