Kisspeptin-10 Raw Materials High Purity Discount for Bulk

Kisspeptin-10 is a peptide hormone, which was discovered by independent research in the fields of cancer biology and reproductive endocrinology. It is encoded by KISS1 gene, which was first identified in the study of human malignant melanoma in the mid-1990s. The researchers observed that the expression of this gene inhibited the metastatic ability of cancer cells, so they initially characterized it as a metastasis suppressor gene. Later, the peptide product produced by KISS1 gene was named kisspeptin-10, which reflected the source of the gene and its peptide essence.

Subsequent studies have shown that kisspeptin-10 exerts its biological effects by binding to a specific G protein-coupled receptor, which was originally called GPR54 and later named KISS1R. The identification of this receptor marks a breakthrough in people's understanding of the physiological function of kisspeptin. Genetic studies on human and animal models show that the functional deletion mutation of KISS1R gene will lead to abnormal puberty development, thus establishing kisspeptin's position as a key regulator of reproductive axis. These findings strongly indicate that kisspeptin is at the core of reproductive neuroendocrine regulation.

Kisspeptin-10 was synthesized as a large precursor protein, and then hydrolyzed by protease into several active peptides with different lengths, including those commonly known as kisspeptin-54, kisspeptin-14, kisspeptin-13 and kisspeptin-10. Despite their different lengths, these peptides all share a common C-terminal sequence, which is essential for receptor activation. These peptides are mainly produced in specific areas of hypothalamus and act upstream of gonadotropin-releasing hormone neurons.

The main physiological function of Kisspeptin is to stimulate the secretion of gonadotropin-releasing hormone, and then trigger the release of hormone and follicle stimulating hormone from the anterior pituitary. Through this mechanism, kisspeptin controls the onset of puberty, regulates gonadal function, and participates in the coordination of reproductive cycle. Experiments show that kisspeptin into human and animals can significantly increase the level of hormone, which proves its powerful stimulating effect on reproductive endocrine system.

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