High purity GLP-1 Weight Loss Peptide Tirzepatide Semaglutide Retatrutide Caglitide

  Product Detail  

What is Semaglutide?
Sema is the newest GLP-1R agonist and was approved by the FDA as a once-weekly injection for the treatment of T2DM in late 2017. The peptide is chemically similar to lira, with the inclusion of two structural modifications (Lau, Bloch, et al., 2015). The first is the replacement of Gly with the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) at position 2. The second is the attachment of octadecanoic diacid to the side chain of Lys-26 through a short polyethylene glycol (PEG) spacer and a γ-glutamic acid linker. The amino acid substitution renders the peptide more resistant to DPP-4 compared to lira, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity for serum albumin, which translates to a half-life of approximately 7 days in humans. 

Sema is a long-acting GLP-1 receptor agonist (GLP-1RA). GLP-1RA activates the GLP-1 receptor by mimicking natural GLP-1, enhances ins secretion in a glucose-dependent manner, inhibits glucagon secretion, delays gastric emptying, and reduces food intake through central appetite suppression, thereby reducing blood sugar and weight loss. GLP-1RA not only has significant hypoglycemic effect, but also has a small risk of hypoglycemia when used alone. At the same time, GLP-1RA has the effects of weight loss, blood pressure reduction, and improvement of blood lipid profile, so it has become one of the world's best-selling hypoglycemic drugs.

Product Function

• Helps slow food leaving your stomach
• Helps prevent your liver from making too much sugar
• Helps the pancreas produce more insul when your blood sugar levels are high
• Can help control blood glucose
• Can reduce hyperglycemia, especially after meals
• Can reduce fasting insul and fasting glucose
• Can reduce hemoglobin A1c
• Can decrease appetite and caloric intake, while inhibiting weight gain
• Has been shown to lower triglyceride levels and oxidative stress from high LDL
• Has been shown to help induce weight loss in obese patients with higher dosing
• Helps decrease leptin and increase leptin sensitivity
• Can increase the conversion of white fat to brown fat
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