Low price China Wholesale High Quality Weight Loss Retatrutide Peptide Vials 5mg 10mg CAS 2381089-83-2 Safe Delivery and Fast
4 Inquiries
169590-42-5
Pharmaceutical Grade
99%
shanghai
silu
box
2025-03-25
peptide,Weight loss peptide
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Product Description
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Inquiry History
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DescriptionECHEMI Editorial ReferenceCelecoxib is a selective COX-2 inhibitor with an IC50 of 40 nM.
Solid
Celecoxib is a member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis. It has a role as a cyclooxygenase 2 inhibitor, a geroprotector, a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a member of toluenes, a sulfonamide, a member of pyrazoles and an organofluorine compound.|Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.|Celecoxib is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.|Celecoxib is a nonsteroidal antiinflammatory drug (NSAID) with selectively for inhibition of cycloxgenase-2 (Cox-2), which is widely used in the therapy of arthritis. Celecoxib has been linked to rare instances of idiosyncratic drug induced liver disease.|Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis.|A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN.Basic Info-
Product Name:
Celecoxib
Other Name:Benzenesulfonamide,4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-;4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;Celecoxib;SC 58635;YM 177;Celebrex;Celocoxib;Celebra;Celecox;Xilebao;Medicoxib;Eurocox;Onsenal;4-[5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;184007-95-2;194044-54-7
CAS No.:169590-42-5
Molecular Formula:C17H14F3N3O2S
InChIKeys:InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N
Molecular Weight:381.37
Exact Mass:381.37
EC Number:200-001-8
UNII:JCX84Q7J1L
NSC Number:758624|719627
DSSTox ID:DTXSID0022777
NCI Thesaurus Code:C1728
Color/Form:Pale yellow solid
ATC Code:L01XX33|M01AH01|L - Antineoplastic and immunomodulating agents|M - Musculo-skeletal system
HScode:2935009090
Categories:
Characteristics-
PSA:
86.4
XLogP3:3.4
Appearance:white to off-white
Density:1.4±0.1 g/cm3
Melting Point:157-159 °C
Boiling Point:529.0±60.0
Flash Point:273.7±32.9 °C
Refractive Index:1.606
Water Solubility:DMSO: >20mg/mL
Storage Conditions:Store at RT
Vapor Pressure:1.2X10-9 mm Hg at 25 deg C /Estimated/
PKA:11.1None
Henrys Law Constant:Henry's Law constant = 7.75X10-13 atm-cu m/mol at 25 °C (est)
Dissociation Constants:11.1|pKa = 11.1 (sulfonamide moiety)
Collision Cross Section:186.4 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|186.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Hydroxyl radical reaction rate constant = 1.45X10-11 cu cm/molec-sec at 25 °C (est)
Research-
Class:
Triple agonist — GCGR, GIPR, GLP-1R
Status:Investigational (Phase 3)
Mechanism:Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.
EC50 (Human GCGR):5.79 nM
EC50 (Mouse GIPR):0.191 nM
EC50 (Mouse GLP1R):0.794 nM
EC50 (Mouse GCGR):2.32 nM
EC50 (Human GLP1R):0.775 nM
EC50 (Human GIPR):0.0643 nM
Source:Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI
Clinical Development:
References-
ChEMBL:DrugBank:KEGG DRUG:PubChem:Disclaimer:
Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
peptide,Weight loss peptide
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Location:
jinan fenghuang guojiguangchang
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Year of Establishment:
2024
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Inquiry History4 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
Celecoxib
100 KG Oct 27, 2025
Pakistan
Celecoxib Usp
200 KG May 13, 2025
Pakistan
Celecoxib
50 KG Sep 24, 2025 
India
Celecoxib
100 G Jan 18, 2024 Post an enquiry for this product
