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CHIR99021 252917-06-9

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CAS No.:

252917-06-9

Port:

shanghai

Packaging:

25kg

Price valid (until):

2025-04-04

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Shaanxi Dideu Medichem Co. Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Product Details of p - Nitrophenol as an Intermediate for Paracetamol

I. Product Overview

p - Nitrophenol, with the English name 4 - Nitrophenol, is an important organic synthesis intermediate. It plays an indispensable role in the pharmaceutical field, especially in the production process of paracetamol (acetaminophen). Its chemical structure is C₆H₅NO₃, and the molecular weight is 139.11.

II. Product Characteristics

Appearance: It is a light yellow or brown crystalline powder, which is stable at room temperature.

Physical Properties: The melting point is 113 - 114 °C. It is slightly soluble in cold water and easily soluble in hot water, ethanol, ether and other organic solvents. The difference in its solubility in different solvents provides convenience for subsequent separation, purification and reaction operations.

Chemical Properties: It has the typical chemical properties of phenolic hydroxyl and nitro groups. The phenolic hydroxyl group makes it have certain acidity and can react with bases to form phenol salts. The nitro group can be converted into an amino group through reduction and other reactions, laying the foundation for the synthesis of paracetamol.

III. Production Process

We adopt an advanced and mature synthesis process to produce p - nitrophenol. Using phenol as the starting material, it undergoes a nitration reaction with nitric acid under the action of catalysts such as sulfuric acid. The reaction process is precisely controlled in terms of temperature, pressure and material ratio to ensure efficient and selective production of p - nitrophenol, while minimizing the generation of by - products such as o - nitrophenol. After the reaction, through a series of separation and purification processes, including distillation, crystallization, recrystallization and other operations, a high - purity p - nitrophenol product is obtained, and the product purity can reach more than 99%.

IV. Quality Standards

We strictly follow relevant international and domestic quality standards to conduct a comprehensive inspection of the product. Our p - nitrophenol product performs excellently in key indicators such as content, impurity content and melting point. Specifically, the content is ≥ 99%, the content of impurities such as o - nitrophenol is ≤ 0.5%, and the melting point range is controlled at 113 - 114 °C, ensuring stable and reliable product quality to meet the high - standard quality requirements of pharmaceutical production enterprises.

V. Application Areas

As a key intermediate for paracetamol, p - nitrophenol is reduced to p - aminophenol, and then reacted with acetic anhydride to synthesize paracetamol. Paracetamol is a widely used antipyretic and analgesic drug globally, used to relieve various symptoms such as cold, fever, headache, and joint pain. In addition, p - nitrophenol also has certain applications in other fields such as medicine, dyes and pesticides. For example, it can be used to synthesize certain antibacterial drugs and dye molecules with specific structures.

VI. Packaging and Storage

Packaging: The product is packaged in 25 - kg cardboard drums, lined with double - layer plastic bags to ensure that the product is not affected by moisture or contaminated during transportation and storage, and is convenient for handling and use.

Storage: Store in a cool and ventilated warehouse. Keep away from fire sources, heat sources and avoid direct sunlight. It should be stored separately from oxidants, acids, alkalis, etc., and do not store them together. The storage area should be equipped with appropriate materials to contain leaks.

VII. Safety Information

p - Nitrophenol is toxic to a certain extent. Inhalation, ingestion or absorption through the skin may be harmful to the body. During the use process, operators should wear appropriate protective equipment, such as safety glasses, gloves, protective clothing, etc. In case of accidental contact, rinse immediately with plenty of water and seek medical attention in a timely manner. The transportation of the product needs to comply with the relevant regulations for the transportation of hazardous chemicals to ensure transportation safety.

We are committed to providing customers with high - quality p - nitrophenol products. If you have any needs or questions, please feel free to contact us, and we will serve you wholeheartedly.

Items	Specifications

Basic Info

Product Name:

GSK 3 inhibitor XVI

Other Name:

3-Pyridinecarbonitrile,6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-;3-Pyridinecarbonitrile,6-[[2-[[4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-;6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile;CHIR 99021;CT 99021;CHIR 911;CIHR 99021;CHIR 99201;GSK 3 inhibitor XVI;GSK 3IXV;Laduviglusib;1485056-50-5

CAS No.:

252917-06-9

Molecular Formula:

C22H18Cl2N8

InChIKeys:

InChIKey=AQGNHMOJWBZFQQ-UHFFFAOYSA-N

Molecular Weight:

465.35

Exact Mass:

465.34

EC Number:

1312995-182-4

UNII:

234CMT4GK4

DSSTox ID:

DTXSID90179931

HScode:

29335990

Categories:

Heterocyclic Compound

Characteristics

PSA:

115

XLogP3:

4.3

Appearance:

white to light brown

Density:

1.5±0.1 g/cm3

Boiling Point:

784.1±70.0°C at 760 mmHg

Flash Point:

428.0±35.7 °C

Refractive Index:

1.700

Water Solubility:

DMSO: soluble2mg/mL, clear (warmed)

Storage Conditions:

-20°C

See More GSK 3 inhibitor XVI Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 2, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More GSK 3 inhibitor XVI Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

Location:
https://www.dideu.com/en/

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
Above $100 million

Total Employees:
Above 1000

Year of Establishment:
2016

Certifications:
ISO Certificate,REACH

Company Profile

Inquiry History