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mod grf 1-29 252917-06-9 Senwayer New Product

Name: mod grf 1-29 252917-06-9 Senwayer New Product
Brand: Senwayer
SKU: pr2503071075
Price: 500 USD
Availability: InStock

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Unit Price:

$500-550/G FOB

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CAS No.:

252917-06-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

wuhan

Brand:

Senwayer

Packaging:

1g/vial

Sample Available:

Yes

Price valid (until):

2027-06-19

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Dingwang Technology (Wuhan) Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

10 days

Qualification:

Main Products:

API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

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Product Description
Seller Information
Inquiry History

Description

Product Detail

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CHIR 99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Acts as Wnt activator. Exhibits >500-fold selectivity for GSK-3 over closely related kinases; also displays >800-fold selectivity against 45 additional enzymes and receptors.

Product name	CHIR-99021
CAS No.	252917-06-9
MF	C22H18Cl2N8
MW	465.34
Boiling point	784.1±70.0 °C(Predicted)
Density	1.48
Storage condition	-20°C
Solubility	DMSO: soluble2mg/mL, clear (warmed)

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ECHEMI Editorial Reference

CHIR-99021 is a GSK-3α/β inhibitor with an IC50 of 10 and 6.7 nM，showing 500-fold selectivity over its closest homologs CDC2 and ERK2, as well as other protein kinases.
CHIR 99021 is a member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a member of imidazoles, a dichlorobenzene, an aminopyrimidine, an aminopyridine, a cyanopyridine, a secondary amino compound and a diamine.

Basic Info

Product Name:

GSK 3 inhibitor XVI

Other Name:

3-Pyridinecarbonitrile,6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-;3-Pyridinecarbonitrile,6-[[2-[[4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-;6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile;CHIR 99021;CT 99021;CHIR 911;CIHR 99021;CHIR 99201;GSK 3 inhibitor XVI;GSK 3IXV;Laduviglusib;1485056-50-5

CAS No.:

252917-06-9

Molecular Formula:

C22H18Cl2N8

InChIKeys:

InChIKey=AQGNHMOJWBZFQQ-UHFFFAOYSA-N

Molecular Weight:

465.35

Exact Mass:

465.34

EC Number:

1312995-182-4

UNII:

234CMT4GK4

DSSTox ID:

DTXSID90179931

HScode:

29335990

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

115

XLogP3:

4.3

Appearance:

white to light brown

Density:

1.5±0.1 g/cm3

Boiling Point:

784.1±70.0°C at 760 mmHg

Flash Point:

428.0±35.7 °C

Refractive Index:

1.700

Water Solubility:

DMSO: soluble2mg/mL, clear (warmed)

Storage Conditions:

-20°C

Research

Class:

GHRH analog (1–29 amino-terminal fragment, 29-amino-acid peptide amide)

Status:

FDA-approved diagnostic agent (Geref, discontinued). NOT for therapeutic use.

Mechanism:

A synthetic 29-amino-acid peptide (H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂) identical to the amino-terminal segment of endogenous human GHRH. Sermorelin binds to the GHRH receptor (GHRHR) on anterior pituitary somatotrophs, stimulating pulsatile GH synthesis and secretion via the cAMP/PKA pathway. Unlike exogenous GH, sermorelin preserves the endogenous GH pulsatility and IGF-1 feedback loop.

EC50 (Ghrhr Ec50):

~0.1–1 nM (cAMP accumulation in rat pituitary cells)

Source:

DrugBank: DB00010. Frohman LA, et al. Endocr Rev. 1986;7(3):223–253.DOI

Clinical Development:

NCT00001390; NCT00527397

FDA:

Geref (approved 1991-10-11)

References

ChEMBL:

CHEMBL1201555

DrugBank:

DB00010

KEGG DRUG:

D08554

PubChem:

PubChem

Literature:

FDA: Geref (NDA 019863, discontinued)

Disclaimer:

Sermorelin was FDA-approved as a diagnostic agent (Geref) for growth hormone deficiency but has been discontinued (not for safety reasons). It is NOT approved for anti-aging, bodybuilding, or therapeutic GH replacement. This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

See More GSK 3 inhibitor XVI Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 2, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More GSK 3 inhibitor XVI Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
10 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2020

Company Certificates
- Verified supplier certificate
- SGS
Dingwang Technology (Wuhan) Co., Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Peptide, Nutritional supplements,food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

10 Inquiries

Country	Product	Purchase Quantity	Date Posted
Canada	252917-06-9	1 KG	Mar 24, 2026
Russia	Pharmaceutical Chemical Anti-hair loss CHIR99021 CAS NO 252917-06-9 in stock 99% white powder	10 G	Mar 7, 2025
Russia	chir-99021	3 G	Apr 30, 2025
Poland	GSK 3 inhibitor XVI	1 G	Oct 12, 2026
Russia	mod grf 1-29	1 G	Mar 13, 2025
United Kingdom	GSK 3 inhibitor XVI	100 G	Sep 23, 2026
Singapore	CHIR-99021	1 G	Sep 1, 2026
Australia	Chir99021	1 G	Jul 13, 2026
Brazil	Na-931 Bioglutide	5 MG	Sep 3, 2025
Russia	CHIR99021	10 G	Mar 4, 2025

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mod grf 1-29 252917-06-9 Senwayer New Product

Product Description

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