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China origin high quality Ruxolitinib Phosphate for the treatment of myeloproliferative neoplasms, CAS#1092939-17-7 buy - large image1

China origin high quality Ruxolitinib Phosphate for the treatment of myeloproliferative neoplasms, CAS#1092939-17-7

Name: China origin high quality Ruxolitinib Phosphate for the treatment of myeloproliferative neoplasms, CAS#1092939-17-7
Brand: HANDOM CHEM
SKU: pr2503071434
Price: 20 USD
Availability: InStock

3 Inquiries

Unit Price: Get Latest Price 

CAS No.:

1092939-17-7

Grade:

Pharmaceutical Grade

Content:

98%

Port:

Shanghai, Shenzhen or Beijing

Brand:

HANDOM CHEM

Packaging:

10g/Bag, 20g/Bag, 50g/Bag, 100g/Bag, 500g/Bag or 1kg/Bag

Price valid (until):

2025-07-31

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DALIAN HANDOM CHEMICALS CO.,LTD.

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

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Product Description
Seller Information
Inquiry History

Description

Product Details

Product Name: Ruxolitinib Phosphate

CAS No.: 1092939-17-7

Molecular Formula: C17H21N6O4P

Molecular Weight: 404.360201

1. Brief Introduction:

Ruxolitinib Phosphate is the phosphate form of Ruxolitinib, which is a tyrosine kinase inhibitor and is mainly used clinically to treat myeloproliferative neoplasms such as chronic myeloid leukemia and myelofibrosis.

Shop China origin high quality Ruxolitinib Phosphate for the treatment of myeloproliferative neoplasms, CAS#1092939-17-7-Detailed Image 1

2. Drug Category:

JAK Inhibitor: Selectively inhibits JAK1 and JAK2 kinases, works by blocking the JAK-STAT signaling pathway, and regulates immune and inflammatory responses.

3. Mechanism of Action:

Inhibits the abnormally active JAK-STAT pathway, reduces the production of pro-inflammatory cytokines (such as IL-6, IFN-γ), and thus inhibits inflammation and abnormal cell proliferation.

Test Items		Specifications
Appearance		White to almost white powder
Identification		IR: Identical versus reference spectrum
Identification		The retention time of the major peak of the sample solution corresponds to that of the standard solution, as obtained in the assay.
Water		Not more than 0.5%
pH Value		2.5 ~ 4.5
Na		Not more than 100 ppm
Pd		Not more than 10 ppm
PO43- (Anhydrous and no solvent basis)		22.4% ~ 25.1%
Enantiomer		Impurity A: Not more than 0.7%
Related Substances	Impurity C	Not more than 0.15%
	Impurity H	Not more than 0.15%
	Impurity E	Not more than 0.15%
	Impurity D	Not more than 0.15%
	Impurity F	Not more than 0.15%
	Impurity B	Not more than 0.15%
	Individual unspecified impurity	Not more than 0.10%
	Total impurities	Not more than 0.5%
Residual Solvents Ⅰ	Methanol	Not more than 3000 ppm
	Acetone	Not more than 5000 ppm
	2-Propanol	Not more than 5000 ppm
	Dichloromethane	Not more than 600 ppm
	Tert-Butylmethyl ether	Not more than 5000 ppm
	Ethyl acetate	Not more than 5000 ppm
	1,4-Dioxane	Not more than 380 ppm
Residual Solvents Ⅱ	n-Heptane	Not more than 4000 ppm
	N,N-Dimethylformamide	Not more than 880 ppm
	Dimethyl sulfoxide	Not more than 5000 ppm
Residual Solvents Ⅲ	Benzene	Not more than 2 ppm
Microbiological Limits	Total aerobic microbial count	Not more than 1000 CFU/g
	Total combined yeasts & mould count	Not more than 100 CFU/g
	Escherichia coli	Negative
Assay (Anhydrous and no solvent basis)		98.0% ~ 102.0%

4. Indications:

※ Myelofibrosis: Relieve splenomegaly and related symptoms (e.g., pain, fatigue).

※ Polycythemia Vera: For patients resistant or intolerant to hydroxyurea.

※ Atopic Dermatitis: Topical or systemic treatment of moderate to severe cases.

※ Graft Versus Host Disease (GVHD): Steroid-refractory acute GVHD.

5. Preparation and Usage:

- Oral Tablets or Topical Application (depending on the indication).
♔ The dosage should be adjusted according to the patient's condition.

6. Packaging:

10g/Bag, 20g/Bag, 50g/Bag, 100g/Bag, 500g/Bag, 1kg/Bag or according to the specific requirements from customers.

7. Storage Conditions:

Preserved in unopened original containers in a cool dry place before using; kept away from direct sunlight, heat and moisture.

8. Shelf Life:

36 months from the date of manufacturing when stored under the above conditions.

Basic Info

Product Name:

Jakafi

Other Name:

1H-Pyrazole-1-propanenitrile,β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-,(βR)-,phosphate (1:1);Jakafi;Ruxolitinib phosphate;INCB 018424 phosphate;INC 424 phosphate;Jakavi

CAS No.:

1092939-17-7

Molecular Formula:

C17H18N6.H3O4P

InChIKeys:

InChIKey=JFMWPOCYMYGEDM-XFULWGLBSA-N

Molecular Weight:

404.360201

Exact Mass:

404.136200

UNII:

436LRU32H5

NCI Thesaurus Code:

C97937

ATC Code:

L01EJ01

HScode:

29331990

Categories:

Antineoplastic Agents

Characteristics

PSA:

161

XLogP3:

2.53778

See More Jakafi Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Reproductive toxicity, Category 2

Specific target organ toxicity â repeated exposure, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H361 Suspected of damaging fertility or the unborn child H373 May cause damage to organs through prolonged or repeated exposure
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Jakafi Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

Location:
RM702, Building 21, Liuhe Road, Ganjingzi Dist, Dalian, Liaoning, China

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2020

Dalian Handom Chemicals Co., Ltd.(HDC CHEM) is a professional 15-Year-Experienced Supplier of APIs & Intermediates, Pharmaceutical Excipients, Food & Nutraceutical Ingredients, Personal Care Chemicals and Specialty Chemicals from northeast of China, which strives to provide customers with high-quality products and comprehensive service across all over the world, our main products cover Retatrutide Lyophilized Powder, Retatrutide, Tirzepatide, Tirzepatide Lyophilized Powder, Semaglutide, Mazdutide, Cagrilintide, LL-37, Thymosin Alpha 1(Thymosin α1), MT-2, MOTS-c, HEP-1, TB-500, NAD+, GHK-Cu, Glow, Klow, Selank, Semax, Glutathione, 5-Amino-1MQ, ARA-290, SS-31, DSIP, SNAP-8, Medetomidine, Medetomidine Hydrochloride, Salcaprozate Sodium, Sodium 8-(2-hydroxybenzamido)octanoate, 2,6-Dimethyl Beta Cyclodextrin, mPEG-DMG-2K, mPEG-DSPE-2K, 1,2-Distearoyl-sn-3-phosphacholine(DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), Pharmaceutical Grade Fructose, Lactose Anhydrous, Lactose Monohydrate, Orotic acid anhydrous, Orotic acid monohydrate, 6-Methyluracil, Chitosan, Mushroom Chitosan, Chitosan Hydrochloride, Chitosan Oligosaccharide, Alginate Oligosaccharide, Inulin, L-Serine, Mung Bean Peptide, Walnut Peptide, Rice Peptide, Oyster Peptide, Sea Cucumber Peptide, Hydrolyzed Keratin, Folic Acid, Vitamin E Acetate, Vitamin B2, Riboflavin Sodium Phosphate, Pyridoxal 5'-phosphate Monohydrate, Vegan Vitamin D3, Vitamin A Palmitate, Vitamin A Acetate, Apple Pectin, Citrus Pectin, Sunflower Pectin, Salidroside, Urolithin A, Milk Thistle Extract, Saffron Extract, Red Clover Extract, Sulforaphane, Glucoraphanin, Soy Isoflavones, Soy Lecithin, Soya Lecithin, Egg Yolk Lecithin, Phosphatidylserine, Cooling Agent WS-3, Cooling Agent WS-5, Cooling Agent WS-10, Cooling Agent WS-12, Cooling Agent WS-23, Cooling Agent WS-27, Menthyl Lactate, Menthyl PCA, Avobenzone, Benzophenone-3 (UV-9), Benzophenone-4 (UV-284), Bis-ethylhexyloxyphenol Methoxyphenyl Triazine (Bemotrizinol), Diethylaminohydroxybenzoyl Hexyl Benzoate (UVA Plus), Diethylhexyl Butamido Triazone (Iscotrizinol), Disodium Phenyl Dibenzimidazole Tetrasulfonate (DPDT), Ethylhexyl Triazone (UVT-150), Homosalate, Octocrylene, 2-Ethylhexyl Salicylate (Octyl Salicylate), 2-Ethylhexyl Trans-4-Methoxycinnamate (OMC), 2-Phenylbenzimidazole-5-Sulfonic Acid (UV-T), Lanolin Anhydrous, Palmitoyl Tripeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Biotinoyl Tripeptide-1, etc.

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	RUCOLITINIB PHOSPAHTE	1 KG	Apr 18, 2025
Pakistan	RUXOLITINIB PHOSPHATE	1 KG	Sep 8, 2025
Pakistan	RUXOLITINIB PHOSPHATE	100.00 G	Dec 31, 2024

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