CAS 67-03-8 Thiamine hydrochloride Biochemical study Phosphorescence photometric analysis of phosphovitamin B polyneuritis

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Appearance: white acicular crystal or crystalline powder, with faint rice chaff like peculiar odor, bitter taste. Melting point 248 ~ 250℃(decomposition). Highly soluble in water (1g soluble in 1mL20℃ water), slightly soluble in ethanol, insoluble in ether, benzene, chloroform and acetone. REDOX action can make it inactive. It has good thermal stability in air and acidic aqueous solution (pH 3.0 ~ 5.0), and is easy to decompose under neutral and alkaline conditions. Mouse transoral LD50 9.0g/kg.
Melting point: 250 °C (dec.)(lit.)
Packing density: 500kg/m3
Density: 1.3766 (rough estimate)
FEMA3322
Refractive index: 1.6000 (estimate)
Flash point: 9°C
Storage conditions: 2-8°C
Solubility: H2O: 0.1g /mL at 20 °C, clear, colorless
Acidity coefficient (pKa)pKa 4.8 (Uncertain); 9.0 (Uncertain)
Form ": crystalline powder
Color: "White to almost white.
PH value: 2.7-3.3
Odor: (Odor)sour mild bitter
synthetic (organic)
Scent type: bland
Water solubility: 1 g/mL
Sensitivity: Light Sensitive & Hygroscopic
JECFA Number1030
Merck14, 9295
BRN3851771
BCS: Class3
Stability: Stable. Flammable. Incompatibility with strong oxidants and reducing agents

Use 1
Vitamin B1 plays an important role in maintaining normal nerve conduction and the normal activity of the heart and digestive system. Lack, prone to beriberi or polyneuritis and other diseases. China stipulates that it can be used for infant food, the amount of use is 4 ~ 8mg/kg; The dosage in cereals and their products is 3.0 ~ 5.0mg/kg; The amount used in liquid and milk drinks is 1 ~ 2mg/kg. This product can be fortified with thiamine nitrate, the specific dosage must be converted.
Use 2
Biochemical research, fluorescence and phosphorescence photometric analysis of phosphorus, clinical drugs belong to the vitamin B group, for the prevention of beriberi, polyneuritis, central nervous system injury and other diseases.
Use 3
This product plays an important role in glucose metabolism. The energy of nervous tissue is mainly supplied by glucose metabolism. Once vitamin B1 is deficient, the energy supply is obstructed, lactic acid and pyruvate accumulate, resulting in multiple neuritis, paraesthesia, limb weakness, neuromuscular pain and atrophy, and myocardial metabolic disorders, including cardiac palpitations, chest tightness, cardiac hypertrophy, liver stasis and peripheral edema. Mild deficiency of vitamin B1 indicates loss of appetite and weight loss and frailty. For vitamin B1 deficiency, high fever, hyperthyroidism, large input of glucose, systemic infection, diabetes and polyneuritis. According to the "Health Standards for the use of food nutrition Fortifier (1993)" issued by the Ministry of Health, vitamin B1 can be used for cereals and their products, beverages, the amount is 3-5 mg/kg, and can also be used for infant food. The dosage is 4-8 mg/kg. Mouse oral toxicity LD507700-15000 mg/kg.
Use 4
Pharmaceutical, biochemical research. Fluorescence and phosphorescence photometric analysis of phosphorus. Determination of mercury by fluorescence.

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