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Amino Acid DL-O-Phosphoserine CAS:17885-08-4 Best Quality

Name: Amino Acid DL-O-Phosphoserine CAS:17885-08-4 Best Quality
Brand: HyperChem
SKU: pr2503241318
Price: 500 USD
Availability: InStock

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CAS No.:

17885-08-4

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/Bag or other quantities

Price valid (until):

2025-04-24

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

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Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
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Inquiry History

Description

Name	DL-O-Phosphoserine
CAS number	17885-08-4
Synonym	DL-2-Amino-3-hydroxypropanoic acid 3-phosphate DL-Serine monophosphoric acid
Related APIs #	Phosphothreonine Phosphotyrosine O-Phosphoethanolamine Phosphoglyceric Acid Phosphocreatine S-Adenosylmethionine (SAMe) Phosphoenolpyruvate (PEP) L-Serine-O-Phosphate
Description	Description: DL-O-Phosphoserine (CAS 407-41-0), also known as phosphorylated serine, is a chemically modified amino acid derivative where a phosphate group is esterified to the hydroxyl (-OH) group of the serine molecule. This modification significantly alters its biochemical properties, making it a critical intermediate in cellular metabolism and signaling pathways. The "DL" designation indicates the racemic mixture (equal parts D- and L-enantiomers), though the L-form is biologically active in most eukaryotic systems. Chemical Properties: Appearance: White crystalline powder Solubility: Highly soluble in water (≥50 mg/mL), slightly soluble in ethanol. Stability: Sensitive to extreme pH, heat, and enzymatic hydrolysis (e.g., phosphatases). Sources: DL-O-Phosphoserine is synthesized industrially via chemical phosphorylation of serine or through enzymatic methods using kinases. It is not typically found in significant quantities in natural food sources but may be produced endogenously in cells during protein post-translational modifications (PTMs). Applications: Research: Used to study phosphorylation-dependent signaling pathways, enzyme kinetics, and protein-protein interactions. Pharmaceuticals: Investigated as a potential neuroprotective agent, cognitive enhancer, or component in drug delivery systems. Nutraceuticals: Marketed as a dietary supplement for brain health, muscle recovery, and metabolic support. Biological Mechanisms DL-O-Phosphoserine plays multifaceted roles in cellular and systemic physiology due to its involvement in phosphorylation cascades, energy metabolism, and neurotransmitter regulation. Below are its key mechanisms: A. Role in Protein Phosphorylation Phosphoserine is a central player in post-translational modifications (PTMs) of proteins. Serine residues on proteins are phosphorylated by serine/threonine kinases (e.g., Akt, MAPK), which modulate protein conformation, activity, and interactions. Examples include: Signal Transduction: Phosphorylation of serine residues in transcription factors (e.g., NF-κB) regulates gene expression in response to stimuli like cytokines or stress. Cell Cycle Control: Cyclin-dependent kinases (CDKs) phosphorylate serine residues on proteins such as retinoblastoma (Rb) to drive cell cycle progression. Metabolic Pathways Serine Biosynthesis Pathway: Phosphoserine is an intermediate in the phosphoserine pathway, where 3-phosphoglycerate is converted to serine via three enzymatic steps. This pathway is critical for producing serine, a precursor for nucleotides, phospholipids, and glutathione. One-Carbon Metabolism: Serine donates a methyl group via serine hydroxymethyltransferase (SHMT), fueling folate cycles essential for DNA synthesis and epigenetic regulation. Neurotransmitter and Neuroprotection NMDA Receptor Modulation: Phosphoserine may enhance NMDA receptor function by serving as a precursor to D-serine, a co-agonist required for glutamate-mediated synaptic plasticity. Myelin Synthesis: Serine is a precursor to phosphatidylserine, a phospholipid vital for myelination and neuronal membrane integrity. Antioxidant Support: By supporting glutathione synthesis, phosphoserine indirectly mitigates oxidative stress in neurodegenerative conditions (e.g., Alzheimer’s, Parkinson’s). Muscle and Energy Metabolism Creatine Synthesis: Serine contributes to creatine production, which is phosphorylated to phosphocreatine—a rapid energy buffer in muscle and brain tissues. Glycolysis Regulation: Phosphoserine derivatives influence enzymes like phosphoglycerate dehydrogenase, linking amino acid metabolism to glycolysis. Usage Guidelines DL-O-Phosphoserine is utilized across research, clinical, and consumer sectors. Below are standardized protocols and precautions: Research Applications In Vitro Studies: Cell Culture: Add 0.1–1 mM to media to study phosphorylation-dependent processes. Use phosphatase inhibitors (e.g., sodium orthovanadate) to prevent degradation. Enzyme Assays: Employ as a substrate for phosphatases or kinases (e.g., alkaline phosphatase, PKA). In Vivo Models: Animal Studies: Administer intraperitoneally (5–20 mg/kg) or orally (10–50 mg/kg) dissolved in saline. Monitor plasma serine levels and phosphorylation markers. Nutraceutical Supplements Dosage: Typical doses range from 100–500 mg/day for cognitive or metabolic support. Formulations: Available as capsules, powders, or combined with nootropics (e.g., choline, phosphatidylserine). Safety: Generally recognized as safe (GRAS) at recommended doses. Contraindicated in individuals with hyperphosphatemia or severe renal impairment. Pharmaceutical Development Drug Delivery: Conjugated to nanoparticles or liposomes to enhance bioavailability for targeting brain or muscle tissues. Clinical Trials: Investigated in Phase II trials for Alzheimer’s disease (e.g., improving NMDA receptor function) and muscle wasting disorders. Pharmacokinetics and Safety: Absorption: Orally administered phosphoserine is absorbed in the small intestine via peptide transporters (PEPT1). Bioavailability is ~40–60%. Distribution: Crosses the blood-brain barrier (BBB) via active transport, with highest concentrations in the liver, kidneys, and brain. Metabolism: Dephosphorylated by alkaline phosphatases in tissues to free serine, which enters central metabolic pathways. Excretion: Excess phosphate is eliminated renally; serine is catabolized to CO₂ or incorporated into proteins. Adverse Effects: Mild gastrointestinal discomfort (nausea, diarrhea) at high doses (>1 g/day). Theoretical risk of disrupting phosphate homeostasis in renal dysfunction. Drug Interactions: Anticoagulants: May potentiate effects of warfarin via unknown mechanisms. Regulatory and Commercial Status Regulatory Approval: Approved as a dietary ingredient in the U.S. (FDA GRAS Notice 1124) and EU (EFSA). Pharmaceutical use remains investigational. Market Availability: Sold by chemical suppliers (e.g., Sigma-Aldrich, Millipore) for research and by nutraceutical brands (e.g., NOW Foods, Jarrow Formulas) for consumer use. Future Directions Emerging research focuses on: Precision Therapeutics: Targeting phosphoserine metabolism in cancers with PHGDH (phosphoglycerate dehydrogenase) overexpression. Neurodegenerative Diseases: Developing phosphoserine analogs to enhance NMDA receptor function without excitotoxicity. Synthetic Biology: Engineering microbes to overproduce phosphoserine for industrial-scale applications. Conclusion DL-O-Phosphoserine is a versatile molecule bridging amino acid metabolism, cellular signaling, and neurological health. Its dual roles as a metabolic intermediate and signaling modulator make it invaluable in both basic research and translational medicine. While current applications emphasize nutritional supplementation, ongoing studies may unlock its potential as a targeted therapeutic agent. Rigorous quality control and adherence to dosing guidelines are essential to maximize benefits and minimize risks.
Molecular Formula	C₃H₈NO₆P
Molecular Weight	185.07 g/mol
Appearance	White crystalline powder
Quality Standard	Enterprise standard; 98%- 102%(ICP-AES)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or -5-8 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

O-Phospho-DL-serine

Other Name:

Serine,O-phosphono-;Serine,dihydrogen phosphate (ester),DL-;Serine,dihydrogen phosphate (ester);O-Phosphonoserine;dl-O-Phosphoserine;DL-O-Serine phosphate;DL-Phosphoserine;Energoserina;Serophen;DL-O-Phosphorylserine;O-Phospho-DL-serine;NSC 90791;2-Amino-3-phosphonooxypropanoic acid;2-Amino-3-(phosphonooxy)propanoic acid;473476-82-3

CAS No.:

17885-08-4

Molecular Formula:

C3H8NO6P

InChIKeys:

InChIKey=BZQFBWGGLXLEPQ-UHFFFAOYSA-N

Molecular Weight:

185.07

Exact Mass:

185.07

EC Number:

206-986-0

NSC Number:

90791

HScode:

2931900090

Categories:

Food Antioxidants

Characteristics

PSA:

139.89000

XLogP3:

-5.1

Density:

1.809g/cm3

Melting Point:

166-167 °C

Boiling Point:

475.4ºC at 760mmHg

Flash Point:

241.3ºC

Water Solubility:

H2O: 50 mg/mL hot, clear, colorless to slightly yellow

Storage Conditions:

-15°C

See More O-Phospho-DL-serine Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More O-Phospho-DL-serine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Italy	DL-O-Phosphoserine	5 KG	Mar 21, 2025

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