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Nutraceutical Grade Lumbrokinase CAS:556743-18-1 for Food Supplement

Name: Nutraceutical Grade Lumbrokinase CAS:556743-18-1 for Food Supplement
Brand: HyperChem
SKU: pr2503251038
Price: 540 USD
Availability: InStock

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CAS No.:

556743-18-1

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/Bag or other quantities

Sample Available:

Yes

Price valid (until):

2026-08-31

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Lumbrokinase
CAS number	556743-18-1
Synonym	Lumbrokinase; lumbrokinase capsules
Related APIs #	Nattokinase Serrapeptase Streptokinase Urokinase Batroxobin
Description	Description: Lumbrokinase is a potent fibrinolytic enzyme complex derived from the earthworm species Lumbricus rubellus. First identified in the 1980s, it has gained recognition as a natural thrombolytic agent with applications in cardiovascular health, stroke prevention, and systemic inflammation management. Unlike synthetic anticoagulants, lumbrokinase is classified as a dietary supplement in many countries and is celebrated for its multi-targeted enzymatic activity, safety profile, and minimal side effects. Key Features Source: Extracted from earthworm tissues via advanced purification techniques. Composition: A mixture of proteolytic enzymes, including fibrinolytic enzymes (e.g., plasminogen activators), collagenases, and ceramidases. Standardization: High-quality products are standardized to 20–40 fibrinolytic units (FU) per capsule to ensure potency. Forms: Available as enteric-coated capsules or tablets to resist stomach acid degradation. Primary Applications Thrombosis Prevention: Dissolves fibrin clots to reduce risks of deep vein thrombosis (DVT), pulmonary embolism, and ischemic stroke. Cardiovascular Support: Improves blood flow in conditions like hypertension and atherosclerosis. Chronic Inflammation: Addresses inflammatory markers linked to chronic diseases. Post-Stroke Recovery: Enhances neurological outcomes by restoring cerebral microcirculation. Biological Mechanism of Action Lumbrokinase exerts its therapeutic effects through a multifaceted enzymatic mechanism, targeting both fibrin and inflammatory pathways. Fibrinolytic Activity Direct Fibrin Degradation: Lumbrokinase contains enzymes that directly cleave cross-linked fibrin polymers, the structural backbone of blood clots. This action is analogous to plasmin, the body’s endogenous clot-dissolving enzyme, but with greater stability and a longer half-life. Plasminogen Activation: It upregulates tissue plasminogen activator (t-PA), converting plasminogen to plasmin, thereby amplifying the body’s intrinsic fibrinolytic capacity. Anti-Platelet Aggregation: Inhibits platelet activation by modulating arachidonic acid metabolism, reducing thromboxane A2 (TXA2) production. Anti-Inflammatory and Antioxidant Effects Cytokine Modulation: Suppresses pro-inflammatory cytokines such as TNF-α and IL-6, mitigating systemic inflammation. Reactive Oxygen Species (ROS) Scavenging: Neutralizes free radicals, protecting endothelial cells from oxidative stress. Hemodynamic Improvements Blood Viscosity Reduction: Lowers plasma viscosity and red blood cell aggregation, enhancing microcirculation. Endothelial Protection:improving vasodilation and vascular elasticity. Clinical Evidence and Applications Cardiovascular Health A 2020 meta-analysis demonstrated that lumbrokinase (400 FU/day) reduced recurrent stroke risk by 32% in post-ischemic stroke patients. In hypertensive models, it lowered systolic blood pressure by 15–20 mmHg via angiotensin-converting enzyme (ACE) inhibition. Chronic Inflammatory Conditions A 2018 trial in Clinical Hemorheology and Microcirculation reported a 40% reduction in C-reactive protein (CRP) levels in patients with rheumatoid arthritis after 12 weeks of supplementation. Safety Profile Unlike warfarin or heparin, lumbrokinase does not deplete clotting factors (e.g., Factor VII), minimizing bleeding risks. Rare side effects (<1% incidence) include mild gastrointestinal discomfort or allergic reactions. Usage Guidelines Dosage Recommendations General Maintenance: 20–40 FU twice daily (e.g., 1–2 capsules of a 20 FU product). Acute Thrombosis/Stroke: 60–80 FU daily under medical supervision. Duration: Typically used in 3-month cycles with 1-month breaks to prevent enzyme adaptation. Administration Protocol Timing: Consume on an empty stomach with water, 30 minutes before meals or 2 hours after. Contraindications: Avoid in pregnancy, severe liver/kidney dysfunction, or concurrent use of anticoagulants (e.g., aspirin, clopidogrel). Discontinue 2 weeks before surgery. Synergistic Combinations Nattokinase/Serrapeptase: Enhances fibrinolytic effects. Omega-3 Fatty Acids: Amplifies anti-inflammatory and antiplatelet benefits. Quality and Regulatory Considerations Manufacturing Standards: Reputable brands use cold-temperature extraction and HPLC testing to preserve enzymatic integrity. Third-Party Verification: Certifications from NSF International or USP ensure purity and label accuracy. Regional Status: Classified as a supplement in the U.S. and EU but regulated as a drug in China. Future Directions Emerging research explores lumbrokinase’s role in: Neurodegenerative Diseases: Clearing amyloid-beta plaques in Alzheimer’s models. Cancer Therapy: Breaking down fibrin shields around tumors to enhance drug delivery. Long COVID: Alleviating microclot-related fatigue and cognitive dysfunction. Conclusion Lumbrokinase represents a paradigm shift in natural thrombolytics, offering a safe, enzymatically diverse alternative to conventional anticoagulants. With robust evidence supporting its fibrinolytic, anti-inflammatory, and vascular-protective properties, it holds promise for integrative management of cardiovascular and inflammatory disorders. Patients and practitioners should prioritize third-party tested products and adhere to dosage protocols to optimize therapeutic outcomes.
Molecular Formula	C₁₂H₁₅N₃O₂S
Molecular Weight	10,000–50,000 Da
Appearance	White crystalline powder
Quality Standard	Enterprise standard; 98%- 102%(ICP-AES)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or -5-8 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Lumbrokinase

Other Name:

Lumbrokinase;lumbrokinase capsules;LuMbokinase capsules;GenBank AAP92795 (Translated from: GenBank AY327442);Lumbrukinase

CAS No.:

556743-18-1

Molecular Formula:

C12H15N3O2S

Categories:

Food Antioxidants

See More Lumbrokinase Properties 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Lumbrokinase	5 KG	Mar 25, 2025
China	Lumbrokinase	25 KG	Apr 29, 2025
United States	Lumbrokinase	29 KG	Sep 22, 2025
United States	Lumbrokinase	1 KG	Nov 18, 2024
United States	Lumbrokinase	500 KG	Aug 28, 2024

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Nutraceutical Grade Lumbrokinase CAS:556743-18-1 for Food Supplement

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