Manufacturer Direct Supply High Purity SANA (MVD1) CAS 42571-07-3 | Anti-Inflammatory Metabolic Modulator for R&D

SANA More Info

SANA, is an orally active small molecule recognized for its pleiotropic anti-inflammatory and metabolic modulating properties. Its mechanism of action involves multiple key cellular pathways: it inhibits NF-κB signaling, activates the Nrf2/Keap1 and AMPK pathways, and suppresses inflammasome activity. This multi-targeted profile distinguishes it from single-pathway modulators and supports its application in research areas including inflammation, metabolism, and immunology.

This compound has demonstrated the ability to induce thermogenesis and reverse insulin resistance in preclinical models. Researchers have utilized it in studies related to obesity, glucose intolerance, skin graft rejection, and insulin resistance, highlighting its broad investigative potential. Its activity has been observed across various cell types, including THP-1 macrophages, RAW 264.7 macrophages, and Hep G2 cells, with studies reporting dose-dependent inhibition of pro-inflammatory cytokines such as IL-6, TNF-α, and IL-1β.

Pharmacologically, SANA acts as a potent inhibitor of NF-κB/p65 nuclear translocation, with studies indicating greater potency compared to salicylic acid at equivalent concentrations. Concurrently, it induces Nrf2/Keap1-dependent expression of antioxidant genes including HO-1, GCLM, and NQO1. This dual anti-inflammatory and antioxidant action, combined with its ability to modulate AMPK and inflammasome pathways, makes 2-Hydroxy-5-(2-nitrovinyl) a valuable tool for investigating complex disease mechanisms where metabolic dysfunction and inflammatory responses are intertwined.

With the CAS number 42571-07-3, this high-purity compound is typically available in research quantities for in vitro and in vivo studies. Its established activity profile and well-characterized mechanism of action support its use in drug discovery and translational research programs targeting metabolic and inflammatory diseases.

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