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2-Amino-3-nitrobenzoic acid

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CAS No.:

606-18-8

Grade:

Pharmaceutical Grade

Packaging:

25kg/Cardboard Drum

Price valid (until):

2025-04-30

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SHANDONG LOOK CHEMICAL CO.,LTD

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate

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Product Description
Seller Information

Description

Product Detail

2-Amino-3-nitrobenzoic Acid (CAS 606-18-8): Multifunctional Chemical Intermediate

Molecular Architecture Analysis

2-Amino-3-nitrobenzoic acid (C7H6N2O4), a structurally complex aromatic compound, features three distinct functional groups strategically positioned on its benzene ring. The carboxylic acid group at position 1 creates strong electron-withdrawing effects, while the adjacent amino (NH2) and nitro (NO2) groups at positions 2 and 3 respectively create unique electronic conjugation patterns. This molecular configuration enables 2-Amino-3-nitrobenzoic acid to participate in various chemical reactions including electrophilic substitution, nucleophilic addition, and redox processes.

Crystallographic Properties

Single-crystal X-ray diffraction studies reveal monoclinic crystal system with space group P21/c. Unit cell parameters: a = 7.892 Å, b = 5.432 Å, c = 12.765 Å, β = 97.8°. The molecular packing diagram shows intermolecular hydrogen bonding between carboxylic oxygen and amino hydrogen atoms (O…H distance 1.85 Å).

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Extended Physicochemical Profile

Parameter	Value	Test Method
Density	1.612 g/cm³	ASTM D4052
Refractive Index	1.657	ASTM D1218
Flash Point	>250°C	ISO 3679
Vapor Pressure	2.3×10-7 mmHg @25°C	OECD 104
Dielectric Constant	3.82	ASTM D150

Advanced Synthetic Chemistry

Industrial-Scale Production

Modern manufacturing utilizes continuous flow reactor technology for improved safety and yield:

Precision nitration: Mixed acid (HNO3/H2SO4 1:3 v/v) at 5±0.5°C
Residence time optimization: 45 minutes with turbulent flow (Re >4000)
In-situ neutralization: Automated pH control (5.8-6.2) using NaOH solution
Crystallization: Anti-solvent precipitation with ethanol/water (3:7 ratio)

Quality Control Protocols

HPLC Analysis: C18 column (4.6×250mm), mobile phase ACN/0.1% H3PO4 (35:65)
FTIR Verification: Characteristic peaks at 1685 cm-1 (C=O), 1530 cm-1 (NO2)
TGA Monitoring: 5% weight loss at 205°C (dehydration), major decomposition @315°C

Cross-Industry Applications

Advanced Pharmaceutical Development

As crucial intermediate in:

Antimycobacterial agents: Core structure in BTZ043 derivatives (Phase III clinical trials)
Kinase inhibitors: Chelating moiety in EGFR-T790M inhibitors
Proteolysis-targeting chimeras (PROTACs): Linker component for E3 ligase recruitment

Next-Gen Material Science

• Metal-Organic Frameworks (MOFs): Building block for gas-selective porous materials
• Conductive polymers: Dopant for polyaniline-based supercapacitors
• Liquid crystal composites: Hydrogen-bonded mesogens with tunable phase transitions

Technical Support Documents

Document	Version	Availability
Material Safety Data Sheet	4.3	PDF Download
Stability Summary	2024.1	Upon Request
Regulatory Compliance	REACH/TSG	Online Access

Basic Info

Product Name:

2-Amino-3-nitrobenzoic acid

Other Name:

Benzoic acid,2-amino-3-nitro-;Anthranilic acid,3-nitro-;2-Amino-3-nitrobenzoic acid;3-Nitroanthranilic acid;NSC 1162

CAS No.:

606-18-8

Molecular Formula:

C7H6N2O4

InChIKeys:

InChIKey=JJPIVRWTAGQTPQ-UHFFFAOYSA-N

Molecular Weight:

182.13

Exact Mass:

182.13

NSC Number:

1162

DSSTox ID:

DTXSID60277211

HScode:

2922499990

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

109

XLogP3:

1.1

Appearance:

WHITE TO BROWN SOLID, POWDER, CRYSTALS, CRYSTALLINE POWDER, AND/OR CHUNKS

Density:

1.6±0.1 g/cm3

Melting Point:

208-209 °C

Boiling Point:

390.4°C at 760 mmHg

Flash Point:

189.9±25.1 °C

Refractive Index:

1.682

Storage Conditions:

Refrigerator

See More 2-Amino-3-nitrobenzoic acid Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 2-Amino-3-nitrobenzoic acid Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate

Location:
hisense intelligence valley,no 2116,of phoenix road

Payment Terms:
TT against copy of documents,D/P,L/C

Average lead Time:
7

Total Annual Revenue:
Less than $1 million

Total Employees:
11-50

Year of Establishment:
2017

SHANDONG LOOK CHEMICAL CO.LTD, a new chemical enterprise in researching, manufacturing and supplying of chemicals located in beautiful “Spring City”-Jinan.Our company mainly working on the researching new-born APIs, intermediate ( especially Carbohydrate derivatives series). Meanwhile, we made huge breakthrough in industries of food, feed additives, cosmetics ,dye and industrial chemicals. Our company enjoyed great reputation both domestic and abroad under the belief of “Integrity management,Quality controlling and Customer orientation”. Web : www.chinalookchemical.com

We had been cooperated with NingXia University and Shandong University on more than ten projects for years and which had been in mass production on the market. We now have more than 80 people in our team and built research center in Jinan and Ningxia. Our manufacturing site allocated in chemical industry parks of Zhangqiu, Heze, Dezhou and Ningxia Fine Chemical Park. We strictly complying with ISO9001 and ISO 2000 standard in manufacturing process, our lab and workshop tightly in accordance with GMP standard.Our products best selling in Europe, South and North America,Asia pacific area and Africa. We sincerely welcome new and regular customers around the world visit us for business negotiation.
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2-Amino-3-nitrobenzoic acid

Product Description

Seller Information

2-Amino-3-nitrobenzoic Acid (CAS 606-18-8): Multifunctional Chemical Intermediate

Molecular Architecture Analysis

Crystallographic Properties

Extended Physicochemical Profile

Advanced Synthetic Chemistry

Industrial-Scale Production

Quality Control Protocols

Cross-Industry Applications

Advanced Pharmaceutical Development

Next-Gen Material Science

Technical Support Documents

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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