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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Dihexa for Sale > supply Best Price Nootropics Dihexa cas1401708-83-5 dihexa Powder 1g/ vial or mg/via
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supply Best Price Nootropics Dihexa cas1401708-83-5 dihexa Powder 1g/ vial or mg/via

TDS 178 Inquiries

Unit Price: Get Latest Price
CAS No.:

1401708-83-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

qingdao

Brand:

First Chems Co., LTD

Packaging:

1mg;5mg;10mg;50mg;100mg

Sample Available:

Yes

Price valid (until):

2025-09-25

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
15 days
Qualification:
Main Products:

Titanium dioxide,npk,pvc,sles,labsa,mdi

  • Product Details

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  





      Product Detail 

     


     


     


    Production Description 

    Product: Dihexa
    Synonyms:PNB-0408; PNB 0408; PNB0408; Dihexa; N-hexanoic-Tyr-Ile-(6) aminohexanoic amide; N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide
    CAS #: 1401708-83-5
    Molecular Formula: C27H44N4O5
    Molecular Mass: 504.672  (g/mol)
    Amino Acid Sequence: Hexanoyl-Tyr-Ile-Ahx-NH2
    Purity: 99.0%
    Appearance: White Lyophilized Powder
    Minimum Order Quantity: 1g
    Test Method: HPLC
    Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below-18° C. 


    Items Specifications
    Product Name  Dehexa
    CAS  1401708-83-5
    Purity  99%
    Molecular Formula C27H44N4O5
    Molecular Weight 504.66

    What is DIHEXA Peptide?


    Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is anoligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte-growth-factor and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
     
    According to a patent, "Short duration safety studies with Dihexa have uncovered no apparent toxicity. Of particular note is a lack of neoplastic induction, since c-Met is recognized as an oncogene. This is unsurprising sinceoncogenesis requires multiple mutations including both oncogene induction and tumor suppressor attenuation."

    DIHEXA Peptide Benefits


    Dihexa dramatically improves cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
     
    These statements have not been evaluated by the fda and are not intented to diagnose, treat, cure or prevent any disease.

    DIHEXA Peptide Mode of Action
    Dihexa is an oligopeptide drug that binds with high affinity to hepatocyte-growth-factor and potentiates its activity at its receptor, c-Met.

    DIHEXA Peptide Dosage
    This depends on your body weight. All of the research carried out so far has used rodent studies, the rats and mice are usually injected with an effective dosage thought to be around 10 μg (mcg) per KG, in humans this is thought to be around the equivalent loading of 1.6 μg per KG in humans, so if you are: 
     
    60 KG (132 lb.) then your ideal daily  oral dose would be 96 μg (mcg)
    70 KG (154 lb.) => 112 μg
    80 KG (176 lb.) => 128 μg
    90 KG (198 lb.) => 144 μg

    Superiority

    1.High quality and competitive price.
    2.Free sample for your evaluation.
    3.Promptly delivery by well-reputed shipping lines.
    4.Trial order is available for testing after samples.
    5.We will inform you all the information at every stage in advance.
    6.Packaging can gear to buyers’ special request. 



    Our service

    1. Reply your inquiry in 24 working hours.
    2. Customized design is available. OEM are welcomed.
    3. Exclusive and unique solution can be provided to our customer by our well-trained and professional engineers and
    staff.
    4. Professional factory: We are manufacturer, specializing in producing all kinds of herb extract for more than 10 years, competitive with good quantity.
    5. As an honest seller, we always use superior raw material, advanced machines, skilled technicians to ensure our products to be finished in high quality and stable feature.

     Our Advantage 

    1.High quality and competitive price.
    2.Free sample for your evaluation.
    3.Promptly delivery by well-reputed shipping lines.
    4.Trial order is available for testing after samples.
    5.We will inform you all the information at every stage in advance.
    6.Packaging can gear to buyers' special request. 



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    Certificates
    ECHEMI Editorial Reference

    Dihexa is a synthetic peptide-based compound and angiotensin IV analog. As a research and pharmaceutical raw material, Dihexa is characterized by its defined molecular structure and peptide properties. It is primarily used for research, analytical testing, compound evaluation, and pharmaceutical development.

    Certificates
    • supply Best Price Nootropics Dihexa cas1401708-83-5 dihexa Powder 1g/ vial or mg/via Certificates 1 TDS

    Basic Info
    Product Name:

    Dihexa

    Other Name:

    L-Isoleucinamide,N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide;Dihexa;N-Hexanoic-Tyr-Ile-(6)aminohexanoic amide

    CAS No.:

    1401708-83-5

    Molecular Formula:

    C27H44N4O5

    InChIKeys:

    InChIKey=XEUVNVNAVKZSPT-JTJYXVOQSA-N

    Molecular Weight:

    504.7

    Exact Mass:

    504.66

    Characteristics
    Density:

    1.111±0.06 g/cm3(Predicted)

    Boiling Point:

    866.2±65.0 °C(Predicted)

    Research
    Class:

    Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator

    Status:

    Research compound — Not FDA approved

    Mechanism:

    A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.

    EC50 (HGF Binding KD):

    65 pM

    Activity note:

    Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).

    Source:

    Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.

    Clinical Development:

    NCT04488419

    References
    PubChem:

    PubChem

    UNII:

    9WYX65A5C2

    Disclaimer:

    Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Titanium dioxide,npk,pvc,sles,labsa,mdi

    Location:

    37 Keji Road, Yanta District, Xi 'an City, Shaanxi Province

    Payment Terms:

    TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    15 days

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    Less than 5

    Year of Establishment:

    2020

    COMPANY OVERVIEW

    First Chems Co., LTD,a joint-stock enterprise with production, export and services of chemicals, has widely adopted world-advanced equipments and management system, and our products quality is assured under the ISO9001 and ISO14001 standards, mainly specializes in developing Agriculture/Fertilizer chemicals series, Washing detergent chemicals series, Soda alkali chemicals series, Water treatment chemical series, etc.

    Our main products include:

    a. Agriculture/Feed chemicals series : Zinc Sulphate, Manganese sulfate etc.), 

    b. Washing detergent chemicals series : (LABSA, SLES, CEDA,STPP, etc.)

    c.  Soda alkali chemicals series : ( Caustic Soda , Sodium Sulphate Anhydrous etc.) 

    d. Water treatment chemical series: (Calcium hypochlorite, TCCA,SDIC, PAC- poly aluminium chloride, PFS, Aluminium sulfate etc.) 

    e. Adsorbent Desiccant Activated Alumina Ball

    f.  Raw material Calcium Aluminate ,Aluminium Hydroxide

  • Inquiry History
    178 Inquiries
    Country Product Purchase Quantity Date Posted
    Canada

    Dihexa lyophilized 1401708-83-5

    1  Aug 23, 2026
    Canada

    Dihexa 1401708-83-5

    1 G Mar 8, 2026
    Bulgaria

    Customized peptides high purity Dihexa with fast shipping door to door CAS 1401708-83-5

    10 G May 27, 2025
    Australia

    Dihexa

    30 G Oct 19, 2026
    United States

    Dihexa

    500 G Aug 19, 2026
    United States

    Dihexa

    25 G Jan 26, 2025
    Russia

    DIHEXA

    50.00 G Aug 14, 2024
    Australia

    Dihexa

    2 G Oct 19, 2026
    United States

    dihexa

    10 MG Sep 28, 2026
    Spain

    Dihexa

    100 MG Aug 30, 2026
    United Arab Emirates

    Diheza

    1 G Aug 28, 2026
    Canada

    Dihexa

    130  Aug 12, 2026
    Brazil

    dihexa

    90 MG Aug 4, 2026
    United States

    Dihexa raw powder

    10 G Jul 26, 2026
    Singapore

    Dihexa

    10 PCS Jul 15, 2026
    United States

    Dihexa

    1 G Jul 11, 2026
    Sweden

    Dihexa

    10 PCS Jul 8, 2026
    Australia

    Dihexa

    1 MT Jul 2, 2026
    United States

    Dihexa

    10 G Jun 14, 2026
    Germany

    Dihexa

    1 G May 25, 2026
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