Hot Selling Best Quality 99% Analgesic Drug Rotundine

1. Overview

1.1 Chemical Name and Structure
Rotundine, chemically known as 2,3,9,10-tetramethoxy-5,8,13,13α-tetrahydro-6H-dibenzo[a,g]quinolizine, is a white or slightly yellow crystalline powder with no odor or taste. Its molecular formula is C₂₁H₂₅NO₄, with a molecular weight of 355.428. The chemical structure is stable but prone to yellowing under light and heat exposure.

1.2 Pharmacological Properties
Rotundine is a non-addictive analgesic with analgesic, sedative, hypnotic, and tranquilizing effects. Its analgesic potency is weaker than that of pethidine but stronger than that of common antipyretic analgesics. At therapeutic doses, Rotundine does not cause respiratory depression or gastrointestinal smooth muscle spasms and is non-addictive, although prolonged use may lead to tolerance.

1.3 Extraction Source
Rotundine is primarily extracted from the dried tubers of the Corydalis yanhusuo plant, a member of the Papaveraceae family, and can also be synthesized chemically.

2. Applications

2.1 Analgesic Effects

• Indications: Rotundine is indicated for the treatment of visceral pain caused by digestive system disorders (such as gastric and duodenal ulcer pain), general headaches, dysmenorrhea, postpartum uterine contractions, and other conditions. It is more effective for chronic persistent pain and visceral dull pain but less effective for acute sharp pain (such as postoperative or traumatic pain) and late-stage cancer pain.
• Mechanism of Action: Rotundine exerts its analgesic effects by inhibiting the ascending reticular activating system in the brainstem and blocking the function of dopamine receptors in the brain.
• Dosage and Administration: For oral administration, the recommended dose for adults is 60–120 mg, taken three times daily.

2.2 Sedative and Hypnotic Effects

• Indications: Rotundine is suitable for patients with tension-related pain or insomnia caused by pain. Its hypnotic effect begins within 15 minutes after administration and lasts for about 2 hours. Due to its concurrent analgesic effect, it is particularly beneficial for patients with pain-induced insomnia.
• Dosage and Administration: For oral administration, the recommended dose for adults is 30–90 mg, taken three times daily, with bedtime administration being more effective.

2.3 Other Applications

• Antitussive Effects: Rotundine can reduce the excitability of the parasympathetic nervous system, weaken or interrupt the afferent nerve impulses, and thus inhibit the cough reflex process, providing antitussive effects.
• Antiarrhythmic Effects: Rotundine can also be used to treat various types of arrhythmias.