Superior Products N-Acetylneuraminic acid

Function of N-acetylneuraminic acid

N-acetylneuraminic acid has been proven to have numerous biological functions, including regulation of blood protein half-life, resistance to various toxins, cell adhesion, glycoprotein cleavage protection, antioxidant properties, promotion of brain development, and prodrugs.

1. Promote brain development

N-acetylneuraminic acid plays a role in mediating gangliosides in the brain. Sialic acid can change the behavior of rats and improve their memory. By comparison between breast-fed and powder-fed infants, the concentration of ganglioside protein and N-acetylneuraminic acid in frontal cortex gray matter were 32% and 22%, respectively, indicating that N-acetylneuraminic acid can increase Synapses form and promote neurodevelopment. Another interesting experiment is to supplement N-acetylneuraminic acid in early piglets to study the learning and memory performance of piglets. In the early development process, the learning ability and memory ability of feeding N-acetylneuraminic acid were enhanced compared with the control group. Studies have shown that the golden period of human brain development is from pregnancy to 2 years old. This stage is a critical period for the adjustment of the number of brain cells, the increase in size, the perfect function, and the formation of the neural network. Therefore, adequate intake of N-acetylneuraminic acid during pregnancy is very important for fetal development. After the baby is born, breast milk is an effective way to supplement N-acetylneuraminic acid, because breast milk contains a large amount of N-acetylneuraminic acid (0.3-1.5mg/ml). However, the liver development of newborns is not yet mature, coupled with the need for rapid growth and development of the brain, it may be that the synthesis of N-acetylneuraminic acid by itself is very limited, especially for premature babies. Therefore, on the one hand, the N-acetylneuraminic acid in breast milk is essential to ensure the normal growth and development of infants. On the other hand, if sufficient N-acetylneuraminic acid is added to the infant milk powder, it will also be important for the infant’s intellectual development. influences.

2. Antioxidant

N-acetylneuraminic acid can consume toxic hydrogen peroxide (H2O2). Japanese scholars observed the toxicity of H2O2 to cells in a medium supplemented with N-acetylneuraminic acid, and confirmed that N-acetylneuraminic acid can inhibit cell death caused by H2O2. These results indicate that N-acetylneuraminic acid can be used as a scavenger of reactive oxygen species.

3. Anti-infection

There are many medical studies related to N-acetylneuraminic acid, which are widely used in the field of pharmaceutical intermediates and have a certain scale of market. Internationally, the market for prodrugs with a relatively large volume is the anti-influenza drug Zanamivir (Zanamivir). The drug is an effective inhibitor of influenza virus, by inhibiting the neuraminidase of influenza virus, thereby changing the aggregation and release of influenza virus in infected cells, and is used to treat the epidemic caused by influenza A (A) virus. cold. The synthesis process is through modification of N-acetylneuraminic acid monomer.

In addition, studies have found that in addition to zanamivir and GM-1 (monosialotetrahexosylganglioside), N-acetylneuraminic acid is also used as a tumor diagnostic agent as a diagnosis of early cancer occurrence and metastasis.

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FAQ

Q1: Are you manufacturer or trading company?

A1:Manufacturer.

Q2: Can I get some sample?
A2: Yes, usually 10-25g sample for free.

Q3: Is there a discount?
A3: Of course, welcome to contact us. Price would be different based on different quantity. For bulk
quantity, we will have discount for you.

Q4: How long for production and delivery?
A4: Most products we have in stock, sent time:Within 1-3 business days after received payment. Customized products further discussed.

Q5: Do you accept ODM or OEM service?
A5: Yes,we accept ODM and OEM services, ranges: Soft gel, Capsule, Tablet, Sachet, Granule,Private Label service, etc. Please contact us to design your own brand product.

Q6: How to deliver the goods?
A6: ≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.

Q7: How to start orders or make payments?
Proforma invoice with our company bank details will be sent to you once the order confirmed by Email. Pls arrange payment by  TT. Goods will be sent after received payment within 1-3 business days.