China Most Professional Manufacturer Supply High Qulity ACACETIN

I. Overview

Acacetin, also known as 5,7-dihydroxy-4'-methoxyflavone, is a naturally occurring flavonoid compound with the molecular formula C₁₆H₁₂O₅ and a molecular weight of 284.26. Its chemical structure contains two phenolic hydroxyl groups and a conjugated carbonyl group, endowing it with strong fluorescent properties and chemical reactivity. Acacetin typically appears as a light yellow solid at room temperature. It is insoluble in water but soluble in organic solvents such as methanol and ethanol.

Acacetin is primarily derived from the Acacia farnesiana plant, a member of the Fabaceae family, as well as from other plants such as Robinia pseudoacacia, Cirsium japonicum, Eupatorium odoratum, Buddleja officinalis, Chrysanthemum morifolium, etc. As an orally active flavonoid compound, acacetin exhibits a variety of biological activities, including antioxidant, anti-inflammatory, antibacterial, antitumor, anti-osteoporotic, immunomodulatory, cardioprotective, and neuroprotective effects.

II. Applications

1. Pharmaceutical Industry

   • Antitumor Effects: Acacetin demonstrates significant anticancer activity, capable of inhibiting the proliferation of various cancer cells, including those of gastric cancer, non-small cell lung cancer, prostate cancer, T-cell leukemia, ovarian cancer, and human osteosarcoma. Its anticancer mechanisms include inducing cancer cell cycle arrest, promoting apoptosis and autophagy, and inhibiting cancer cell invasion and migration.
   • Anti-inflammatory and Immunomodulatory Effects: Acacetin can inhibit the release of inflammatory factors, thereby alleviating inflammatory responses and holding potential therapeutic value for inflammatory-mediated autoimmune diseases.
   • Cardioprotective Effects: Through its antioxidant and anti-inflammatory properties, acacetin reduces cardiomyocyte apoptosis, prevents atrial fibrillation, and offers protection to the heart.
   • Neuroprotective Effects: Acacetin inhibits glutamate release, reduces neuronal apoptosis, and decreases the secretion of inflammatory factors, thereby protecting against neurodegenerative diseases and neural injuries.
   • Anti-osteoporotic Effects: Acacetin promotes the proliferation and differentiation of osteoblasts, exhibiting anti-osteoporotic effects.
   • Antibacterial Effects: Acacetin inhibits the growth of pathogenic bacteria such as Staphylococcus aureus, making it potentially useful in the treatment of infectious diseases.
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2. Cosmetics Industry

   • Skin Tightening: Acacetin plays a role in skin-tightening formulations for sensitive skin, such as in firming and anti-wrinkle powders/lotions. It can improve skin condition, offering anti-aging and whitening effects.
   • Moisturizing and Nourishing: Rich in various nutrients beneficial to the human body, acacetin possesses good moisturizing properties and is suitable for people with all skin types.
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3. Food Industry

   • Food Additives: As a natural food additive, acacetin can be incorporated into the manufacturing processes of various foods, including bread, pastries, candies, and beverages, to enhance their nutritional value and functionality, as well as to improve their taste.
   • Health Foods: Acacetin can be formulated into health foods in the form of capsules or chewing gums, offering benefits such as soothing the mind, regulating qi, calming the nerves, and promoting blood circulation.
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4. Other Applications

   • Fragrances and Cigarettes: Acacetin, with its rich aroma, is used in the formulation of high-end perfumes and cosmetics. Additionally, extracts containing acacetin can be utilized in cigarette production to improve the quality of cigarettes.