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Acacetin

Acacetin structure

CAS No:
480-44-4
Formula:
C16H12O5
Chemical Name:
Acacetin
Synonyms:
4H-1-Benzopyran-4-one,5,7-dihydroxy-2-(4-methoxyphenyl)-;Acacetin;Flavone,5,7-dihydroxy-4′-methoxy-;5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;Buddleoflavonol;5,7-Dihydroxy-4′-methoxyflavone;Linarigenin;Apigenin 4′-methyl ether;4′-O-Methylapigenin;4′-Methylapigenin;2-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one;LY 064233;NSC 76061;4′-O-Methyl-5,7,4′-trihydroxyflavone
Categories:
Natural Products > Flavonoids

Description

1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Aca

5,7-dihydroxy-4'-methoxyflavone is a monomethoxyflavone that is the 4'-methyl ether derivative of apigenin. It has a role as an anticonvulsant and a plant metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It derives from an apigenin. It is a conjugate acid of a 5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate.

Acacetin Basic Attributes

Molecular Weight：

284.26

Exact Mass：

284.26

EC Number：

207-552-3

UNII：

KWI7J0A2CC

NSC Number：

76061

DSSTox ID：

DTXSID00197383

HScode：

2914509090

Characteristics

PSA：

XLogP3：

2.1

Appearance：

Pale-yellow needles

Density：

1.4±0.1 g/cm3

Melting Point：

263 °C

Boiling Point：

518.6°C at 760 mmHg

Flash Point：

198.3±23.6 °C

Refractive Index：

1.669

Storage Conditions：

2-8°C

Vapor Pressure：

2.25E-11mmHg at 25°C

Collision Cross Section：

167.06 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|172.92 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|160.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|172.3 Å² [M-H]-

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

DJ3002000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Drug Information

MeSH Entry Terms：

acacetin

Acacetin Use and Manufacturing

Uses

VEGF expression inhibitor and tumor angiogenesis. A flavonoid with antiaggregatory activity in human blood.

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

Computed Properties

Molecular Weight:284.26
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:284.06847348
Monoisotopic Mass:284.06847348
Topological Polar Surface Area:76
Heavy Atom Count:21
Complexity:424
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Acacetin

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Acacetin

CAS No.: 480-44-4

Grade: pharmaceutical grade

Content: 99%

Inquiry
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CN
5 YRS

Business licensed

Trader Supplier of API,nutrition supplements,plant extract,peptide,HCG

Acacetin 98% Powder 480-44-4 Senwayer

CAS No.: 480-44-4

Grade: Top Product

Content: 98%

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myland health Contact Supplier

CN
6 YRS

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Manufactory Supplier of Calcium 2-Oxoglutarate,Oleoylethanolamide,N-Acetyl-L-cysteine ethyl ester

Acacetin 98% supplement

Unit Price: $320-400 /KG FOB

CAS No.: 480-44-4

Grade: Food Grade

Content: 98%

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Guide of Acacetin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Acacetin

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