Nutritional Supplement Calcium 2-Oxoglutarate Raw Powder

I. Overview

• Basic Information:
  Calcium 2-oxoglutarate (Calcium α-Ketoglutarate) is an important bioactive molecule with CAS numbers 71686-01-6 (anhydrous form) and 402726-78-7 (monohydrate form). Its molecular formulas are C₅H₄CaO₅ (anhydrous) and C₅H₈CaO₅·H₂O (monohydrate), with molecular weights of 184.16 and 206.21, respectively. It appears as a white to off-white powder, typically with a purity exceeding 98%, and remains relatively stable under normal temperature, pressure, and neutral environmental conditions.

• Chemical Structure and Properties:
  Calcium α-Ketoglutarate is the calcium salt form of α-ketoglutaric acid, a key intermediate in the tricarboxylic acid cycle (Krebs cycle) that participates in the generation of ATP or GTP. Its molecular structure contains a ketone carbonyl group at the α position and two carboxyl groups, which, when combined with calcium, form a stable calcium salt.

• Physiological Functions:
  Calcium α-Ketoglutarate exhibits various physiological functions in the body, including serving as the primary carbon skeleton for nitrogen assimilation reactions, regulating protein synthesis and skeletal development, maintaining immune system homeostasis, and reducing oxidative stress. Additionally, it acts as a reversible inhibitor of tyrosinase, showing potential antioxidant and anti-aging effects.

II. Applications

1. Dietary Supplements:
   • Promoting Health and Longevity:
     As an antioxidant, Calcium α-Ketoglutarate helps eliminate free radicals, protecting the body from harmful oxidative substances and thereby promoting overall health. Studies have indicated that supplementation with Calcium α-Ketoglutarate can significantly reduce biological age and extend healthy lifespan.
   • Supporting Bone and Muscle Health:
     Containing calcium, Calcium α-Ketoglutarate can supplement calcium levels in the human body, helping to maintain normal bone density and prevent bone-related diseases such as osteoporosis. It also promotes muscle growth and recovery, enhancing physical performance and endurance.
   • Enhancing Metabolism and Energy Levels:
     Calcium α-Ketoglutarate participates in cellular energy metabolism and amino acid synthesis, aiding in the regulation of metabolism, increasing the body's energy levels, and facilitating more efficient fat burning.
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2. Pharmaceutical Field:
   • Disease Treatment and Prevention:
     Calcium α-Ketoglutarate holds potential application value in treating diseases caused by metabolic disorders and malnutrition associated with chronic diseases. It can assist in improving conditions through its metabolic regulation and nutritional supplementation properties.
   • Biochemical Research Reagent:
     In biochemical laboratories, Calcium α-Ketoglutarate is often used as an important reagent for studying intracellular metabolic mechanisms such as the tricarboxylic acid cycle, helping to elucidate the mechanisms of metabolic disorders under disease states.
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3. Feed Additives:
   • Promoting Healthy Growth in Animals:
     Adding Calcium α-Ketoglutarate to animal feed can provide a calcium source, ensuring the normal development of animal bones and promoting healthy growth. It also improves feed utilization efficiency, enhances animal disease resistance, and boosts breeding benefits.
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4. Cosmetics and Skincare:
   • Anti-Aging and Skin Health:
     Although direct applications are currently limited, the antioxidant and anti-aging effects of Calcium α-Ketoglutarate suggest potential value in the cosmetics field. Future research and development may lead to its application in anti-aging skincare products to help maintain healthy, youthful skin.