East Chem Piroctone O lamine

I. Basic Information

1. CAS No.：68890-66-4
2. Molecular Formula：C₁₄H₂₈N₂O₃
3. Molecular Weight：272.38 g/mol
4. EC Number：272-619-2
5. 
   

II. Technical Specifications (Cosmetic/Pharmaceutical Grade)

III. Physicochemical Properties

1. Solubility：
   • Water: 50 g/L (25°C), readily soluble to form clear solutions;
2. • pH Range: Stable at pH 4-9; may decompose in strongly acidic (pH<3) or alkaline (pH>10) conditions;
   • Thermal Stability: Stable below 100°C, gradual decomposition above 120°C;
   • Incompatibility: Avoid direct contact with strong oxidizing agents or metal ions (e.g., Fe³⁺, Cu²⁺), which may form complexes.
3. Surface Activity: Non-surface-active; primarily used as a functional additive.

IV. Application Characteristics

1. Core Functions：
   • Antifungal: Targets ergosterol synthesis in Malassezia spp., effective for dandruff treatment;
   • Antibacterial: Inhibits Staphylococcus aureus and Escherichia coli with ≥99% efficacy (at 0.5% concentration);
   • Anti-inflammatory Adjuvant: Reduces scalp inflammation triggered by fungal metabolites.
2. Typical Applications：

   Industry	Application	Recommended Concentration	Function
   Cosmetics	Anti-dandruff shampoo	0.2-1.0%	Antidandruff, regulates scalp microbiome
   	Conditioner/hair mask	0.1-0.5%	Inhibits fungi, relieves itching
   	Body wash/body lotion	0.05-0.3%	Prevents back acne and pityriasis versicolor
   Pharmaceuticals	Antifungal cream/lotion	1.0-2.0%	Treats tinea corporis and seborrheic dermatitis
   Industrial	Water-based paint preservative	0.05-0.2%	Inhibits microbial contamination, extends shelf life

V. Safety and Regulatory Information

1. Toxicological Data：
   • Acute Oral Toxicity (Rat): LD₅₀ > 2000 mg/kg (low toxicity);
   • Skin Irritation: Non-irritating (0.5% aqueous solution rabbit skin test);
   • Eye Irritation: Slightly irritating (avoid direct contact).
2. Regulatory Compliance：
   • China: Listed in the Cosmetic Raw Materials Inventory (2021 Edition) as a preservative and antidandruff agent, maximum allowable concentration 1.0%;
   • EU: Compliant with EC No 1223/2009, permitted for use (CAS 68890-66-4);
   • US FDA: Approved as an OTC drug ingredient for antidandruff products (concentration ≤1.0%).
3. UN Number/Hazard Class: Non-hazardous chemical; no UN number, classified as general cargo for transportation.

VI. Storage and Packaging

1. Storage Conditions：
   • Store in a cool, dry place (temperature ≤25°C, humidity ≤60%), away from light and heat sources;
   • Use polyethylene (PE) or glass containers; avoid metal containers.
2. Packaging Specifications：
   • Standard: 25 kg/cardboard drum (lined with PE bag);
   • Sample: 1 kg/aluminum foil bag.
3. Shelf Life: 3 years unopened; recommend using within 6 months after opening.

VII. Precautions

1. Compatibility Recommendations：
   • Compatible with cationic surfactants (e.g., guar hydroxypropyltrimonium chloride) and nonionic surfactants;
   • Avoid direct mixing with anionic surfactants (e.g., SLS/SLES), which may cause precipitation (pre-test compatibility is required).
2. Handling Protection：
   • Wear protective gloves and goggles; avoid inhalation of dust or contact with skin/mucous membranes;
   • In case of eye contact, rinse immediately with plenty of water and seek medical advice.

Reference Standards

• Cosmetic Safety Technical Specifications (2015 Edition)
• USP-NF (United States Pharmacopeia-National Formulary)
• ISO 22716:2007 (Cosmetic Good Manufacturing Practices)

Company Introduction: East Chemsources Limited was established in 2008, is a professional company engaged in the development of chemical products. In the past of 15 years，through continuous technological innovation and the use of talent introduction advantages, we have achieved rapid development, and has become an international diversified modern chemical enterprise. At present, our products have been exported to more than 80 countries,including food additives, medical raw materials, chemical products and personal care.

Since the establishment of the company, always adhere to the credibility first, quality first enterprise creed. Our company is committed to creating a customer-centric, customer-demand-oriented, customer value creation and achievement of customer dreams for the purpose of the service concept, with a broad vision and broad mind, committed to creating good benefits and market operation, to build corporate brand.