4-Dimethylaminobenzaldehyde raw material

Name	4-Dimethylaminobenzaldehyde
CAS number	100-10-7
Description	para-Dimethylaminobenzaldehyde is an organic compound containing amine and aldehyde moieties which is used in Ehrlich's reagent and Kovac's reagent to test for indoles. The carbonyl group typically reacts with the electron rich 2-position of the indole but may also react at the C-3 or N-1 positions.It may also be used for determination of hydrazine.
Structure
Appearance	white solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

4-Dimethylaminobenzaldehyde More Info

4-Dimethylaminobenzaldehyde (4-DMAB), also known as p-Dimethylaminobenzaldehyde, is an organic compound with the chemical formula C₉H₁₁NO. Here is a detailed introduction to this compound:

1. Molecular Structure and Properties

IUPAC Name: 4-(Dimethylamino)benzaldehyde

Molecular Formula: C₉H₁₁NO

Molecular Weight: 149.19 g/mol

Structure: It consists of a benzaldehyde core with a dimethylamino group (-N(CH₃)₂) attached to the 4-position (para position) of the benzene ring.

Physical Properties:

Appearance: Usually appears as a yellow to reddish-brown crystalline powder or solid.

Melting Point: Approximately 72–75 °C (162–167 °F).

Solubility: Soluble in organic solvents such as ethanol, diethyl ether, and chloroform; slightly soluble in water.

2. Chemical Reactivity

Aldehyde Group Reactions: The aldehyde functional group (-CHO) can undergo typical reactions such as nucleophilic addition, oxidation (e.g., to form 4-dimethylaminobenzoic acid), and condensation (e.g., with amines to form imines).

Amino Group Effects: The electron-donating dimethylamino group enhances the reactivity of the aldehyde and influences the compound’s aromaticity, making it useful in various organic syntheses.

3. Applications

Chemical Analysis:

It is a key reagent in the Ehrlich’s reagent, used for detecting indole compounds (e.g., tryptophan, serotonin) and certain steroids.

Commonly used in colorimetric assays, where it forms a pink or red complex with specific analytes, enabling quantitative analysis.

Organic Synthesis:

Serves as an intermediate in the synthesis of dyes, pharmaceuticals, and other organic compounds. For example, it can be used to prepare Schiff bases or heterocyclic compounds.

Pharmaceutical Research:

Involved in the synthesis of some drug candidates due to its role in forming functional molecules with potential biological activity.

4. Safety and Handling

Hazards: May cause skin and eye irritation; prolonged exposure may pose health risks. Inhalation or ingestion should be avoided.

Storage: Store in a cool, dry place away from light and moisture to prevent oxidation or degradation.

Handling Precautions: Use protective gloves and eyewear; work in a well-ventilated area or fume hood.

5. Related Compounds

Structural analogs include 2-dimethylaminobenzaldehyde and 3-dimethylaminobenzaldehyde, which differ in the position of the dimethylamino group on the benzene ring. Each has distinct reactivity and applications in organic chemistry.

4-DMAB’s combination of aldehyde and amino functionalities makes it a versatile reagent in both analytical chemistry and synthetic organic synthesis.